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A gain-of-function TPC2 variant R210C increases affinity to PI(3,5)P2 and causes lysosome acidification and hypopigmentation.

Autor: Wang, Qiaochu, Wang, Zengge, Wang, Yizhen, Qi, Zhan, Bai, Dayong, Wang, Chentong, Chen, Yuanying, Xu, Wenjian, Zhu, Xili, Jeon, Jaepyo, Xiong, Jian, Hao, Chanjuan, Zhu, Michael Xi, Wei, Aihua, Li, Wei

Publikováno v: Nature Communications; 1/14/2023, Vol. 14 Issue 1, p1-16, 16p

Targeting overexpressed antigens in glioblastoma via CAR T cells with computationally designed high-affinity protein binders.

Autor: Xia Z; Westlake Disease Modeling Laboratory, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China.; Research Center for Industries of the Future, Westlake University, Hangzhou, China.; Key Laboratory of Growth Regulation and Translational Research of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, China.; Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, Hangzhou, China.; School of Life Sciences, Westlake University, Hangzhou, China., Jin Q; Westlake Disease Modeling Laboratory, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China.; Research Center for Industries of the Future, Westlake University, Hangzhou, China.; School of Life Sciences, Westlake University, Hangzhou, China.; Artificial Intelligence Drug Design Core Laboratory, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China., Long Z; Westlake Disease Modeling Laboratory, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China.; Research Center for Industries of the Future, Westlake University, Hangzhou, China.; Key Laboratory of Growth Regulation and Translational Research of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, China.; Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, Hangzhou, China.; School of Life Sciences, Westlake University, Hangzhou, China., He Y; School of Life Sciences, Westlake University, Hangzhou, China., Liu F; Department of Neurosurgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China., Sun C; Westlake Disease Modeling Laboratory, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China.; School of Medicine, Zhejiang University, Hangzhou, China., Liao J; Westlake Disease Modeling Laboratory, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China.; Research Center for Industries of the Future, Westlake University, Hangzhou, China.; School of Life Sciences, Westlake University, Hangzhou, China.; Artificial Intelligence Drug Design Core Laboratory, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China., Wang C; Department of Neurosurgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China., Wang C; Westlake Disease Modeling Laboratory, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China.; Research Center for Industries of the Future, Westlake University, Hangzhou, China.; School of Life Sciences, Westlake University, Hangzhou, China.; Artificial Intelligence Drug Design Core Laboratory, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China., Zheng J; Department of Neurosurgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China., Zhao W; Westlake Disease Modeling Laboratory, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China.; Research Center for Industries of the Future, Westlake University, Hangzhou, China.; Key Laboratory of Growth Regulation and Translational Research of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, China.; Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, Hangzhou, China.; School of Life Sciences, Westlake University, Hangzhou, China., Zhang T; Westlake Disease Modeling Laboratory, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China.; Research Center for Industries of the Future, Westlake University, Hangzhou, China.; School of Life Sciences, Westlake University, Hangzhou, China.; Artificial Intelligence Drug Design Core Laboratory, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China., Rich JN; University of Pittsburgh Medical Center Hillman Cancer Center, Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA., Zhang Y; School of Life Sciences, Westlake University, Hangzhou, China., Cao L; Westlake Disease Modeling Laboratory, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China. caolongxing@westlake.edu.cn.; Research Center for Industries of the Future, Westlake University, Hangzhou, China. caolongxing@westlake.edu.cn.; School of Life Sciences, Westlake University, Hangzhou, China. caolongxing@westlake.edu.cn.; Artificial Intelligence Drug Design Core Laboratory, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China. caolongxing@westlake.edu.cn., Xie Q; Westlake Disease Modeling Laboratory, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China. xieqi@westlake.edu.cn.; Research Center for Industries of the Future, Westlake University, Hangzhou, China. xieqi@westlake.edu.cn.; Key Laboratory of Growth Regulation and Translational Research of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, China. xieqi@westlake.edu.cn.; Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, Hangzhou, China. xieqi@westlake.edu.cn.; School of Life Sciences, Westlake University, Hangzhou, China. xieqi@westlake.edu.cn.

Publikováno v: Nature biomedical engineering [Nat Biomed Eng] 2024 Oct 17. Date of Electronic Publication: 2024 Oct 17.