Proton pump inhibitors suppress DNA damage repair and sensitize treatment resistance in breast cancer by targeting fatty acid synthase

Autor: Wang, Chao J., Li, Deren, Danielson, Jacob A., Zhang, Evan H., Dong, Zizheng, Miller, Kathy D., Li, Lang, Zhang, Jian-Ting, Liu, Jing-Yuan

Publikováno v: In Cancer Letters 1 July 2021 509:1-12

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FASN Regulates Cellular Response to Genotoxic Treatments by Increasing PARP-1 Expression and DNA Repair Activity via NF-κB and SP1

Autor: Wu, Xi, Dong, Zizheng, Wang, Chao J., Barlow, Lincoln James, Fako, Valerie, Serrano, Moises A., Zou, Yue, Liu, Jing Yuan, Zhang, Jian Ting

Publikováno v: ETSU Faculty Works.

Fatty acid synthase (FASN), the sole cytosolic mammalian enzyme for de novo lipid synthesis, is crucial for cancer cell survival and associates with poor prognosis. FASN overexpression has been found to cause resistance to genotoxic insults. Here we

Externí odkaz: https://dc.etsu.edu/etsu-works/15116

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Corrigendum: eIF3a Regulation of NHEJ Repair Protein Synthesis and Cellular Response to Ionizing Radiation.

Autor: Tumia R; Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN, United States., Wang CJ; Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN, United States., Dong T; Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN, United States., Ma S; Department of Cancer Biology, University of Toledo College of Medicine and Life Sciences, Toledo, OH, United States., Beebe J; Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN, United States., Chen J; Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN, United States., Dong Z; Department of Cancer Biology, University of Toledo College of Medicine and Life Sciences, Toledo, OH, United States., Liu JY; Department of Medicine, University of Toledo College of Medicine and Life Sciences, Toledo, OH, United States., Zhang JT; Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN, United States.; Department of Cancer Biology, University of Toledo College of Medicine and Life Sciences, Toledo, OH, United States.

Publikováno v: Frontiers in cell and developmental biology [Front Cell Dev Biol] 2021 Jan 07; Vol. 8, pp. 629218. Date of Electronic Publication: 2021 Jan 07 (Print Publication: 2020).