Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Wandi Zhu"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Enhancing influenza vaccine cross-protection is imperative to alleviate the significant public health burden of influenza. Heterologous sequential immunization may synergize diverse vaccine formulations and routes to improve vaccine potency
Externí odkaz:
https://doaj.org/article/2efe9602ec3047b2939e8ead92772ce7
Autor:
Wandi Zhu, Lai Wei, Chunhong Dong, Ye Wang, Joo Kim, Yao Ma, Gilbert X. Gonzalez, Bao-Zhong Wang
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 30, Iss , Pp 421-437 (2022)
Increasing preclinical and clinical results have demonstrated that mRNA vaccines efficiently prevent infectious diseases and are safe in animal models and humans. In this study, we fabricated a multivalent influenza mRNA lipid nanoparticle (LNP) vacc
Externí odkaz:
https://doaj.org/article/13e2101a7c6940d088ca27f0046f8e01
Publikováno v:
Viruses, Vol 16, Iss 1, p 120 (2024)
mRNA-based vaccine technology has been significantly developed and enhanced, particularly highlighted by the authorization of mRNA vaccines for addressing the COVID-19 pandemic. Various biomaterials are developed in nano-scales and applied as mRNA va
Externí odkaz:
https://doaj.org/article/40e591f61755413486da13e4db5986a6
Publikováno v:
Pharmacological Research, Vol 192, Iss , Pp 106765- (2023)
Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality, imposing an increasing global health burden. Cardiac ion channels (voltage-gated NaV, CaV, KVs, and others) synergistically shape the cardiac action potential (AP) and
Externí odkaz:
https://doaj.org/article/771442bc546b4349ad59eb1d7e897f5b
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
The full range of cell functions is under-determined in most human diseases. The evidence that somatic cell competition and clonal imbalance play a role in non-neoplastic chronic disease reveal a need for a dedicated effort to explore single cell fun
Externí odkaz:
https://doaj.org/article/95f7fc1bbc284bd69de4489cab338407
Autor:
Jonathan D. Moreno, MD, PhD, Wandi Zhu, PhD, Kathryn Mangold, MS, Woenho Chung, BS, Jonathan R. Silva, PhD
Publikováno v:
JACC: Basic to Translational Science, Vol 4, Iss 6, Pp 736-751 (2019)
Summary: Antiarrhythmic treatment strategies remain suboptimal due to our inability to predict how drug interactions with ion channels will affect the ability of the tissues to initiate and sustain an arrhythmia. We built a multiscale molecular model
Externí odkaz:
https://doaj.org/article/eb3b4ebdc4e742ec9c4c12b82759495f
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
The voltage-gated Na+ channel regulates the initiation and propagation of the action potential in excitable cells. The major cardiac isoform NaV1.5, encoded by SCN5A, comprises a monomer with four homologous repeats (I-IV) that each contain a voltage
Externí odkaz:
https://doaj.org/article/9f32dc39af854d98adabd1ec00e41505
Autor:
Wandi Zhu, Wei Wang, Paweorn Angsutararux, Rebecca L. Mellor, Lori L. Isom, Jeanne M. Nerbonne, Jonathan R. Silva
Publikováno v:
JCI Insight, Vol 6, Iss 15 (2021)
Native myocardial voltage-gated sodium (NaV) channels function in macromolecular complexes comprising a pore-forming (α) subunit and multiple accessory proteins. Here, we investigated the impact of accessory NaVβ1 and NaVβ3 subunits on the functio
Externí odkaz:
https://doaj.org/article/3a1cd7dc535f4598ae819c3d1643d27f
Autor:
Huang Cao, Kaitao Zhao, Yongxuan Yao, Jing Guo, Xiaoxiao Gao, Qi Yang, Min Guo, Wandi Zhu, Yun Wang, Chunchen Wu, Jizheng Chen, Yuan Zhou, Xue Hu, Mengji Lu, Xinwen Chen, Rongjuan Pei
Publikováno v:
Protein & Cell, Vol 9, Iss 11, Pp 930-944 (2018)
Abstract The secondary structures of hepatitis C virus (HCV) RNA and the cellular proteins that bind to them are important for modulating both translation and RNA replication. However, the sets of RNA-binding proteins involved in the regulation of HC
Externí odkaz:
https://doaj.org/article/e9f98613571442ae90bb3719dace6f61
Autor:
Zhengqi Wang, Tian Mi, Heath L. Bradley, Jonathan Metts, Himalee Sabnis, Wandi Zhu, Jack Arbiser, Kevin D. Bunting
Publikováno v:
Antioxidants, Vol 10, Iss 6, p 956 (2021)
Acute myeloid leukemia (AML) is a heterogeneous disease with a high relapse rate. Cytokine receptor targeted therapies are therapeutically attractive but are subject to resistance-conferring mutations. Likewise, targeting downstream signaling pathway
Externí odkaz:
https://doaj.org/article/55cef3b857214f6c9597debf32e669f4