Unveiling the intracellular survival gene kit of trypanosomatid parasites.

Autor: Daniella Castanheira Bartholomeu, Rita Marcia Cardoso de Paiva, Tiago A O Mendes, Wanderson D DaRocha, Santuza M R Teixeira

Publikováno v: PLoS Pathogens, Vol 10, Iss 12, p e1004399 (2014)

Trypanosomatids are unicellular protozoans of medical and economical relevance since they are the etiologic agents of infectious diseases in humans as well as livestock. Whereas Trypanosoma cruzi and different species of Leishmania are obligate intra

Externí odkaz: https://doaj.org/article/460e9090f5854806a0cfcf0b8ce2aac8

Antigenicity and protective efficacy of a Leishmania amastigote-specific protein, member of the super-oxygenase family, against visceral leishmaniasis.

Autor: Vivian T Martins, Miguel A Chávez-Fumagalli, Lourena E Costa, Adriana M C Canavaci, Adriana M C C Martins, Paula S Lage, Daniela P Lage, Mariana C Duarte, Diogo G Valadares, Rubens D M Magalhães, Tatiana G Ribeiro, Ronaldo A P Nagem, Wanderson D Darocha, Wiliam C B Régis, Manuel Soto, Eduardo A F Coelho, Ana Paula Fernandes, Carlos A P Tavares

Publikováno v: PLoS Neglected Tropical Diseases, Vol 7, Iss 3, p e2148 (2013)

BackgroundThe present study aimed to evaluate a hypothetical Leishmania amastigote-specific protein (LiHyp1), previously identified by an immunoproteomic approach performed in Leishmania infantum, which showed homology to the super-oxygenase gene fam

Externí odkaz: https://doaj.org/article/1ed48caba5074aee8f85afeec8e6a389

Trypanin disruption affects the motility and infectivity of the protozoan Trypanosoma cruzi

Autor: Jose L. Saenz-Garcia, Beatriz S. Borges, Normanda Souza-Melo, Luiz V. Machado, Juliana S. Miranda, Lisandro Alfonso Pacheco-Lugo, Nilmar S. Moretti, Richard Wheleer, Lia C. Soares Medeiros, Wanderson D. DaRocha

Publikováno v: Repositório Institucional da FIOCRUZ (ARCA)
Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
Frontiers in Cellular and Infection Microbiology, Vol 11 (2022)
Frontiers in Cellular and Infection Microbiology

Universidade Federal do Paraná. Laboratório de Genômica Funcional de Parasitos. Curitiba, PR, Brasil. Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Biologia Celular. Curitiba, PR, Brasil. Universidade Federal de São Paulo. Esc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::601eb87801cd2b72a4cb473081f64dcc
https://www.arca.fiocruz.br/handle/icict/51869

Editing the Trypanosoma cruzi genome with zinc finger nucleases

Autor: Melissa Soares-Simões, Viviane Grazielle-Silva, Isabel Roditi, Santuza M. R. Teixeira, Wanderson D. DaRocha, Gabriela Schumann Burkard, Gabriela de Assis Burle-Caldas

Publikováno v: Molecular and Biochemical Parasitology. 212:28-32

Gene function studies in Trypanosoma cruzi, the protozoan parasite that causes Chagas disease, have been hindered by the lack of efficient genetic manipulation protocols. In most organisms, insertion and deletion of DNA fragments in the genome are de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe04be947aea500062a6370da4475d5e
https://doi.org/10.1016/j.molbiopara.2017.01.002

Engineering a single-chain antibody against Trypanosoma cruzi metacyclic trypomastigotes to block cell invasion

Autor: Philippe Billiald, Juliana de Moura, Wanderson D. DaRocha, Larissa Magalhães Alvarenga, Cristian Andrés Cortez Plaza, Lisandro Pacheco-Lugo, Lara Maria Kalempa Demeu, Juliana Miranda, Kelin Gonçalves de Oliveira, Rodrigo Jahn Soares, Nobuko Yoshida

Publikováno v: PLoS ONE, Vol 14, Iss 10, p e0223773 (2019)
PLoS ONE
14(10), (2019)
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Repositorio Digital USB
Universidad Simón Bolívar
instacron:Universidad Simón Bolívar

Trypanosoma cruzi is a flagellate protozoan pathogen that causes Chagas disease. Currently there is no preventive treatment and the efficiency of the two drugs available is limited to the acute phase. Therefore, there is an unmet need for innovative

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aea6630309b3e606febab1c2a7ba946
https://doaj.org/article/f2d994cfc7cd4b4583e4169afee97c6a