The Accumulation of Tau-Immunoreactive Hippocampal Granules and Corpora Amylacea Implicates Reactive Glia in Tau Pathogenesis during Aging

Autor: Wander, Connor M., Tseng, Jui-Heng, Song, Sheng, Al Housseiny, Heba A., Tart, Dalton S., Ajit, Aditi, Ian Shih, Yen-Yu, Lobrovich, Rebecca, Song, Juan, Meeker, Rick B., Irwin, David J., Cohen, Todd J.

Publikováno v: In iScience 24 July 2020 23(7)

Compensatory remodeling of a septo-hippocampal GABAergic network in the triple transgenic Alzheimer's mouse model.

Autor: Wander, Connor M¹ (AUTHOR), Li, Ya-Dong^1,2,3 (AUTHOR) yadlee@126.com, Bao, Hechen^1,2 (AUTHOR), Asrican, Brent^1,2 (AUTHOR), Luo, Yan-Jia^1,2,4 (AUTHOR), Sullivan, Heather A⁵ (AUTHOR), Chao, Tzu-Hao Harry^6,7 (AUTHOR), Zhang, Wei-Ting^6,7 (AUTHOR), Chéry, Samantha L² (AUTHOR), Tart, Dalton S¹ (AUTHOR), Chen, Ze-Ka^1,2 (AUTHOR), Shih, Yen-Yu Ian^6,7 (AUTHOR), Wickersham, Ian R⁵ (AUTHOR), Cohen, Todd J^2,6 (AUTHOR), Song, Juan^1,2 (AUTHOR) juansong@email.unc.edu

Publikováno v: Journal of Translational Medicine. 4/15/2023, Vol. 21 Issue 1, p1-17. 17p.

Corpora amylacea are associated with tau burden and cognitive status in Alzheimer's disease.

Autor: Wander, Connor M.^1,2 (AUTHOR), Tsujimoto, Tamy Harumy Moraes³ (AUTHOR), Ervin, John F.⁴ (AUTHOR), Wang, Chanung⁵ (AUTHOR), Maranto, Spencer M.¹ (AUTHOR), Bhat, Vanya¹ (AUTHOR), Dallmeier, Julian D.⁶ (AUTHOR), Wang, Shih-Hsiu Jerry^4,7 (AUTHOR), Lin, Feng-Chang³ (AUTHOR), Scott, William K.^6,8,9 (AUTHOR), Holtzman, David M.⁵ (AUTHOR), Cohen, Todd J.^1,10 (AUTHOR) toddcohen@neurology.unc.edu

Publikováno v: Acta Neuropathologica Communications. 8/8/2022, Vol. 10 Issue 1, p1-17. 17p.

Additional file 1 of Corpora amylacea are associated with tau burden and cognitive status in Alzheimer’s disease

Autor: Wander, Connor M., Tsujimoto, Tamy Harumy Moraes, Ervin, John F., Wang, Chanung, Maranto, Spencer M., Bhat, Vanya, Dallmeier, Julian D., Wang, Shih-Hsiu Jerry, Lin, Feng-Chang, Scott, William K., Holtzman, David M., Cohen, Todd J.

Additional file 1: Figure S1. CA analysis of AD cases spanning Braak stages I–VI. A Representative brightfield images of full dentate gyrus architecture in patient tissue samples from Braak I–VI. Inset (dashed box) indicates sample region used in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59f1377b95346ac352ed8fbd6718f7f9

Additional file 3 of Corpora amylacea are associated with tau burden and cognitive status in Alzheimer’s disease

Autor: Wander, Connor M., Tsujimoto, Tamy Harumy Moraes, Ervin, John F., Wang, Chanung, Maranto, Spencer M., Bhat, Vanya, Dallmeier, Julian D., Wang, Shih-Hsiu Jerry, Lin, Feng-Chang, Scott, William K., Holtzman, David M., Cohen, Todd J.

Additional file 3: Figure S2. CA analysis of a refined AD cohort lacking outliers. Scatter plot of refined patient cohort, CA Density vs Braak Stage I, II, III, IV, V, and VI. (112 patients in black, 12 outliers identified by Grubb’s test, Q = 0.05

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fa932844df4da9eb0ada01db714afac