Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Wanda Y. Li"'
Autor:
Shawn P. Kubli, Larsen Vornholz, Gordon Duncan, Wenjing Zhou, Parameswaran Ramachandran, Jerome Fortin, Maureen Cox, SeongJun Han, Robert Nechanitzky, Duygu Nechanitzky, Bryan E. Snow, Lisa Jones, Wanda Y. Li, Jillian Haight, Andrew Wakeham, Mark R. Bray, Tak W. Mak
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Myeloid cells modulate the immune response within the tumour microenvironment, but the underlying mechanisms remain largely unknown. Here, the authors show that Fcmr – the putative receptor for soluble IgM – is a potent negative regulator of anti
Externí odkaz:
https://doaj.org/article/249fbfe56ab6438d997eb47907be7294
Autor:
Zhenyue Hao, Yi Sheng, Gordon S. Duncan, Wanda Y. Li, Carmen Dominguez, Jennifer Sylvester, Yu-Wen Su, Gloria H.Y. Lin, Bryan E. Snow, Dirk Brenner, Annick You-Ten, Jillian Haight, Satoshi Inoue, Andrew Wakeham, Alisha Elford, Sara Hamilton, Yi Liang, Juan C. Zúñiga-Pflücker, Housheng Hansen He, Pamela S. Ohashi, Tak W. Mak
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
The E3 ligase Mule has been previously reported to be essential for B cell development and function by modulating p53 ubiquitination and degradation. Here Haoet al. identify KLF4 as a novel ubiquitination target of Mule and show it controls T cell pr
Externí odkaz:
https://doaj.org/article/e6eb6c78746d4519b89d713cb4a6a1dc
Autor:
Shawn P. Kubli, Larsen Vornholz, Gordon Duncan, Wenjing Zhou, Parameswaran Ramachandran, Jerome Fortin, Maureen Cox, SeongJun Han, Robert Nechanitzky, Duygu Nechanitzky, Bryan E. Snow, Lisa Jones, Wanda Y. Li, Jillian Haight, Andrew Wakeham, Mark R. Bray, Tak W. Mak
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-1 (2019)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/75fabd1ca5c3402c819e4a294285652c
Autor:
Jerome Fortin, Ming-Feng Chiang, Cem Meydan, Jonathan Foox, Parameswaran Ramachandran, Julie Leca, François Lemonnier, Wanda Y. Li, Miki S. Gams, Takashi Sakamoto, Mandy Chu, Chantal Tobin, Eric Laugesen, Troy M. Robinson, Annick You-Ten, Daniel J. Butler, Thorsten Berger, Mark D. Minden, Ross L. Levine, Cynthia J. Guidos, Ari M. Melnick, Christopher E. Mason, Tak W. Mak
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Mutations in IDH1, IDH2 , and TET2 are recurrently observed in myeloid neoplasms. IDH1 and IDH2 encode isocitrate dehydrogenase isoforms, which normally catalyze the conversion of isocitrate to α-ketoglutarate (α-KG). Oncogenic IDH1/2 mutations con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98c0be24618f25a597313a325fc02981
https://doi.org/10.1073/pnas.2208176120
https://doi.org/10.1073/pnas.2208176120
Autor:
Jerome Fortin, Ming-Feng Chiang, Cem Meydan, Jonathan Foox, Parameswaran Ramachandran, Julie Leca, Francois Lemonnier, Wanda Y. Li, Miki S. Gams, Takashi Sakamoto, Mandy Chu, Chantal Tobin, Eric Laugesen, Troy M. Robinson, Annick You-Ten, Daniel J. Butler, Thorsten Berger, Mark D. Minden, Ross L. Levine, Cynthia J. Guidos, Ari M. Melnick, Christopher E. Mason, Tak W. Mak
Publikováno v:
Blood Cancer Discovery. 4:A16-A16
Mutations in IDH1, IDH2, and TET2 are recurrently observed in myeloid neoplasms. IDH1 and IDH2 encode isocitrate dehydrogenase isoforms, which normally catalyze the conversion of isocitrate to α-ketoglutarate (α-KG). Oncogenic IDH1/2 mutations conf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e0c9ea68932d950dc64dba65f44beade
https://doi.org/10.1158/2643-3249.aml23-a16
https://doi.org/10.1158/2643-3249.aml23-a16
Autor:
Guangxun Gao, Zhe Wang, Tak W. Mak, Yuanlin Zhao, Yuan Yuan, Risheng Yang, Julie Leca, Jing Ye, Wenjing Zhou, Alan Tseng, Mary E. Saunders, Andrew Wakeham, Yu Gu, Liming Xiao, Feng Zhang, Lijun Zhang, Ying Yang, Wanda Y. Li, Thorsten Berger, Xing Gao, Jerome Fortin
Publikováno v:
Blood. 137:945-958
Isocitrate dehydrogenase (IDH) mutations are common genetic alterations in myeloid disorders, including acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). Epigenetic changes, including abnormal histone and DNA methylation, have been imp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d9b063c63a1289680f22b9c039e6c18
https://doi.org/10.1182/blood.2020007075
https://doi.org/10.1182/blood.2020007075
Autor:
Sarah A. Dick, Anthony Wong, Homaira Hamidzada, Sara Nejat, Robert Nechanitzky, Shabana Vohra, Brigitte Mueller, Rysa Zaman, Crystal Kantores, Laura Aronoff, Abdul Momen, Duygu Nechanitzky, Wanda Y. Li, Parameswaran Ramachandran, Sarah Q. Crome, Burkhard Becher, Myron I. Cybulsky, Filio Billia, Shaf Keshavjee, Seema Mital, Clint S. Robbins, Tak W. Mak, Slava Epelman
Publikováno v:
Science Immunology. 7
Resident macrophages orchestrate homeostatic, inflammatory, and reparative activities. It is appreciated that different tissues instruct specialized macrophage functions. However, individual tissues contain heterogeneous subpopulations, and how these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3020bfb5ad90e5f99c75ec08329283af
https://doi.org/10.1126/sciimmunol.abf7777
https://doi.org/10.1126/sciimmunol.abf7777
Autor:
Parameswaran Ramachandran, Vuk Stambolic, Jerome Fortin, Ruxiao Tian, Wanda Y. Li, Kelsey Hodgson, Graham Hill, Tak W. Mak, Jillian Haight, Ida Zarrabi, Andrew Wakeham, Bryan E. Snow, Christian Bassi, Chantal Tobin
Publikováno v:
J Clin Invest
In order to sustain proficient life-long hematopoiesis, hematopoietic stem cells (HSCs) must possess robust mechanisms to preserve their quiescence and genome integrity. DNA-damaging stress can perturb HSC homeostasis by affecting their survival, sel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a035272631d4cfb5e3b2d3920978460e
https://doi.org/10.1172/jci131698
https://doi.org/10.1172/jci131698
Autor:
Pavol Lukáč, Roberto Chiarle, Aldo Scarpa, Claudia Curcio, Michela Capello, Wanda Y. Li, Luca Vannucci, Gianluca Mucciolo, Roberta Curto, Dmitry Stakheev, Maria Antonietta Satolli, Paola Cappello, Paolo Provero, Rita T. Lawlor, Francesco Novelli, Cecilia Roux, Daniele Giordano, Tak W. Mak
Publikováno v:
Proc Natl Acad Sci U S A
A hallmark of cancer, including pancreatic ductal adenocarcinoma (PDA), is a massive stromal and inflammatory reaction. Many efforts have been made to identify the anti- or protumoral role of cytokines and immune subpopulations within the stroma. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bf2631e4c2c899cf8a5d98635d991c5
https://doi.org/10.1073/pnas.2020395118
https://doi.org/10.1073/pnas.2020395118
Autor:
Philippe Gaulard, Andrew Wakeham, Rob A. Cairns, Katherine Yen, Rohini Narayanaswamy, Bryan E. Snow, Corinne Haioun, François Lemonnier, Romain Pelletier, Erica Tobin, Angelo Paci, Wanda Y. Li, Tak W. Mak, Virginie Fataccioli, Anaïs Pujals, Satoshi Inoue, Laurence de Leval, A. Dupuy, Sophie Broutin, Nadine Martin, Shengfang Jin
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol. 113, no. 52, pp. 15084-15089
Oncogenic isocitrate dehydrogenase (IDH)1 and IDH2 mutations at three hotspot arginine residues cause an enzymatic gain of function that leads to the production and accumulation of the metabolite 2-hydroxyglutarate (2HG), which contributes to the dev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c4d8407cfb9300a5e4a76e1d03c53c8
https://doi.org/10.1073/pnas.1617929114
https://doi.org/10.1073/pnas.1617929114