Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Wanda W.-S. Chan"'
Autor:
Zhixiong Ye, Elizabeth T. Birzin, Meng-Hsin Chen, Louis Locco, Sheng-Shung Pong, Ravi P. Nargund, Rupa M. Parmar, Roy G. Smith, Ying-Duo Gao, Scott D. Feighner, Wanda W.-S. Chan, James M. Schaeffer, Arthur A. Patchett, Raman K. Bakshi, Allan D. Blake, Andrew D. Howard, Susan P. Rohrer
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 10:5-8
Quinazolinone derivatives were synthesized and evaluated as non-peptidic growth hormone secretagogues. Modeling guided design of quinazolinone compound 21 led to a potency enhancement of greater than 200-fold compared to human growth hormone secretag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccb965f4e0f30dfe4382a988470dcd5a
https://doi.org/10.1016/s0960-894x(99)00584-3
https://doi.org/10.1016/s0960-894x(99)00584-3
Autor:
Roy G. Smith, Wanda W.-S. Chan, Kang Cheng, Bridget Butler, William R. Schoen, Judith M. Pisano, Peter Lin, Matthew J. Wyvratt, Michael H. Fisher
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:3237-3242
Systematic investigation of acyclic analogs of L-692,429, the prototype benzolactam growth hormone secretagogue, has helped to further define the structural requirements for the release of growth hormone from rat pituitary cells for this class of sec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b51fe42906a04dc601581c56a093358b
https://doi.org/10.1016/s0960-894x(99)00568-5
https://doi.org/10.1016/s0960-894x(99)00568-5
Autor:
James M. Schaeffer, Edward C. Hayes, Susan P. Rohrer, M. Dashkevicz, Allan D. Blake, Wanda W.-S. Chan, Rupa M. Parmar, Roy G. Smith
Publikováno v:
Biochemical and Biophysical Research Communications. 263:276-280
Somatostatin (SST) regulates growth hormone (GH) secretion from pituitary somatotrophs by interacting with members of the SST family of G-protein-coupled receptors (sst1-5). We have used potent, nonpeptidyl SST agonists with sst2 and sst5 selectivity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e65867730940c9da8181aed28f133ba7
https://doi.org/10.1006/bbrc.1999.1376
https://doi.org/10.1006/bbrc.1999.1376
Autor:
Bridget Butler, Thomas M. Jacks, Roy G. Smith, Kang Cheng, Patrick P. Pollard, Wanda W.-S. Chan, Meng-Hsin Chen, Arthur A. Patchett, Liente Wei
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:1261-1266
The synthesis and biological activities of a series of spiroheterocyclic growth hormone secretagogues are reported. Modification of the spiroindane part-structure of the prototypal secretagogue L-162,752 revealed that the spiroindane could be replace
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aedd98125879e2be470e2cd88aede45
https://doi.org/10.1016/s0960-894x(99)00183-3
https://doi.org/10.1016/s0960-894x(99)00183-3
Autor:
Arthur A. Patchett, Zhijian Lu, Bridget Butler, Thomas M. Jacks, Liente Wei, Gerard J. Hickey, Kang Cheng, Wanda W.-S. Chan, Klaus D. Schleim, James R. Tata
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:3657-3659
During an effort to search for more potent growth hormone secretagogues, we discovered a class of compounds of which the best compound 8 was 7-fold more active in vitro than the best compound in the series we revealed before [Tata, J. R.; Lu, Z.; Jac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e8c3b7539d8b855d96922e120d5b9a5
https://doi.org/10.1016/j.bmcl.2007.04.050
https://doi.org/10.1016/j.bmcl.2007.04.050
Autor:
Steven M. Hutchins, James M. Schaeffer, Lihu Yang, Wanda W.-S. Chan, Ralph T. Mosley, Alex Pasternak, Min Shu, Sylvia J. Degrado, Scott C. Berk, Forrest Foor, Roy G. Smith, John M. Klopp, Sudha W. Mitra, Arthur A. Patchett, Sheng-Jian Cai, Kevin T. Chapman, Yusheng Xiong, Rupa M. Parmar, Dong-Ming Shen, Allan D. Blake, Elizabeth T. Birzin, Susan P. Rohrer, Edward C. Hayes
Publikováno v:
Science. 282:737-740
Nonpeptide agonists of each of the five somatostatin receptors were identified in combinatorial libraries constructed on the basis of molecular modeling of known peptide agonists. In vitro experiments using these selective compounds demonstrated the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7eb9c2dd1f85ffd368680116fb63c3a0
https://doi.org/10.1126/science.282.5389.737
https://doi.org/10.1126/science.282.5389.737
Autor:
Nancy N. Tsou, Liente Wei, Zhijian Lu, Gerard J. Hickey, Roy G. Smith, Klaus D. Schleim, James R. Tata, Kwan Leung, Arthur A. Patchett, Shuet-Hing Lee Chiu, Wanda W.-S. Chan, Thomas M. Jacks, Bridget Butler, Kang Cheng
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:2319-2324
The design, synthesis, and activities of a series of short duration spiroindane growth hormone secretagogues are reported. Incorporation of a readily metabolized ester into the spiroindane benzylic position provided a series of highly potent orally a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8228b4951c97f924f6505ffa315e8e12
https://doi.org/10.1016/s0960-894x(97)00421-6
https://doi.org/10.1016/s0960-894x(97)00421-6
Autor:
Robert J. De Vita, Wanda W.-S. Chan, Bridget Butler, Alison J. Frontier, Kang Cheng, Michael H. Fisher, Roy G. Smith, William R. Schoen, Matthew J. Wyvratt
Publikováno v:
Helvetica Chimica Acta. 80:1244-1259
The synthesis of a variety of potent macrocyclic growth hormone secretagogues, i.e.5, 9, 12, and 20–22, based on the known lead structure L-692,429 (1) is described. These conformationally constrained growth hormone secretagogues were prepared by j
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06efc8a4fda5f2a9d581c4ffe56f9e83
https://doi.org/10.1002/hlca.19970800421
https://doi.org/10.1002/hlca.19970800421
Autor:
Bridget Butler, Wanda W.-S. Chan, Liente Wei, Roy G. Smith, Marcia M. Murphy, Arthur A. Patchett, Kang Cheng, Gerard J. Hickey, Thomas M. Jacks, Ravi P. Nargund, David B. R. Johnston, James R. Tata
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:663-668
The synthesis and activities of a series of spiroindane growth hormone secretagogues is reported. Modification of the benzylic position of the spiroindane has resulted in a dramatic increase in potency resulting in subnanomolar peptidomimetic growth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df035d623bcfdef04708a98c8911fbc1
https://doi.org/10.1016/s0960-894x(97)00075-9
https://doi.org/10.1016/s0960-894x(97)00075-9
Autor:
Arthur A. Patchett, Mark G. Steiner, Bridget Butler, Wanda W.-S. Chan, Liente Wei, Kang Cheng, Meng-Hsin Chen, Roy G. Smith, Thomas M. Jacks
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:2163-2168
A series of spiroindane growth hormone secretagogues that vary in their amino side chains is reported. Variations in these side chains markedly affect growth hormone release in vitro and in vivo . The best side chain in this series of secretagogues i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4ff10ecfb197cc8d21dd709daaa8d02
https://doi.org/10.1016/0960-894x(96)00394-0
https://doi.org/10.1016/0960-894x(96)00394-0