Výsledky vyhledávání - "Wanda Stirling"

Akademický článek

Correction: Resistance to MPTP-Neurotoxicity in α-Synuclein Knockout Mice Is Complemented by Human α-Synuclein and Associated with Increased β-Synuclein and Akt Activation.

Autor: Bobby Thomas, Allen S. Mandir, Neva West, Ying Liu, Shaida A. Andrabi, Wanda Stirling, Valina L. Dawson, Ted M. Dawson, Michael K. Lee

Publikováno v: PLoS ONE, Vol 7, Iss 3 (2012)

Externí odkaz: https://doaj.org/article/e68a3298f3114f5aa480f902061ff7b9

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Akademický článek

Resistance to MPTP-neurotoxicity in α-synuclein knockout mice is complemented by human α-synuclein and associated with increased β-synuclein and Akt activation.

Autor: Bobby Thomas, Allen S Mandir, Neva West, Ying Liu, Shaida A Andrabi, Wanda Stirling, Valina L Dawson, Ted M Dawson, Michael K Lee

Publikováno v: PLoS ONE, Vol 6, Iss 1, p e16706 (2011)

Genetic and biochemical abnormalities of α-synuclein are associated with the pathogenesis of Parkinson's disease. In the present study we investigated the in vivo interaction of mouse and human α-synuclein with the potent parkinsonian neurotoxin, M

Externí odkaz: https://doaj.org/article/7e4bdda06f3a4f10a3b7d914de48c44b

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Amyloid Pathology Is Associated with Progressive Monoaminergic Neurodegeneration in a Transgenic Mouse Model of Alzheimer's Disease

Autor: Alena Savonenko, Mi Jeong Yoo, Mary E. Blue, David R. Borchelt, Donald L. Price, Laura A. Mamounas, Michael K. Lee, Ying Liu, W. Ernest Lyons, Wanda Stirling

Publikováno v: The Journal of Neuroscience. 28:13805-13814

β-Amyloid (Aβ) pathology is an essential pathogenic component in Alzheimer's disease (AD). However, the significance of Aβ pathology, including Aβ deposits/oligomers and glial reactions, to neurodegeneration is unclear. In particular, despite the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06d5342085d546a3956f76cdc65ccb98
https://doi.org/10.1523/jneurosci.4218-08.2008

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Axonal transport of human α-synuclein slows with aging but is not affected by familial Parkinson's disease-linked mutations

Autor: Paul N. Hoffman, Donald L. Price, Wenxue Li, Wanda Stirling, Michael K. Lee

Publikováno v: Journal of Neurochemistry. 88:401-410

Biochemical and genetic abnormalities of alpha-synuclein (alpha-Syn) are implicated in the pathogenesis of Parkinson's disease (PD) and other alpha-synucleinopathies. The abnormal intraneuronal accumulations of alpha-Syn in Lewy bodies (LBs) and Lewy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4c11d6259b0bf1a4e9d88d3c376b683f
https://doi.org/10.1046/j.1471-4159.2003.02166.x

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Resistance to MPTP-Neurotoxicity in α-Synuclein Knockout Mice Is Complemented by Human α-Synuclein and Associated with Increased β-Synuclein and Akt Activation

Autor: Bobby Thomas, Allen S. Mandir, Neva West, Ying Liu, Shaida A. Andrabi, Wanda Stirling, Valina L. Dawson, Ted M. Dawson, Michael K. Lee

Publikováno v: PLoS ONE
PLoS ONE, Vol 7, Iss 3 (2012)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb1d94dea881bc59565aeccb1772f342
http://europepmc.org/articles/PMC3307770

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Resistance to MPTP-Neurotoxicity in α-Synuclein Knockout Mice Is Complemented by Human α-Synuclein and Associated with Increased β-Synuclein and Akt Activation

Autor: Valina L. Dawson, Allen S. Mandir, Bobby Thomas, Shaida A. Andrabi, Neva West, Michael K. Lee, Ted M. Dawson, Wanda Stirling, Ying Liu

Publikováno v: PLoS ONE
PLoS ONE, Vol 6, Iss 1, p e16706 (2011)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e14419369ff1ef9dd29ad4c3d0f22b3
http://europepmc.org/articles/PMC3031616

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Ubiquitin-proteasome system stress sensitizes ovarian cancer to proteasome inhibitor-induced apoptosis

Autor: Richard B.S. Roden, Wanda Stirling, Martina Bazzaro, Ie Ming Shih, Alessia Zoso, Antonio Santillan, Michael K. Lee

Publikováno v: Cancer research. 66(7)

The ubiquitin-proteasome system (UPS) mediates targeted protein degradation. Notably, the UPS determines levels of key checkpoint proteins controlling apoptosis and proliferation by controlling protein half-life. Herein, we show that ovarian carcinom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95a58a2dfe7bbab0f04bb561a27cbb77
https://pubmed.ncbi.nlm.nih.gov/16585202

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Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 --Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice

Autor: Dike Qui, Neal G. Copeland, Allen S. Mandir, Xueying Xu, Nancy A. Jenkins, Wanda Stirling, Donald L. Price, Ted M. Dawson, Yanqun Xu, Michael K. Lee

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 99(13)

Mutations in α-synuclein (α-Syn) cause Parkinson's disease (PD) in a small number of pedigrees with familial PD. Moreover, α-Syn accumulates as a major component of Lewy bodies and Lewy neurites, intraneuronal inclusions that are neuropathological

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0cdafae69f48db972c982a06ceb452e
https://pubmed.ncbi.nlm.nih.gov/12084935

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