Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Wanda Pakulska"'
Publikováno v:
Molecular Simulation. 42:628-641
Molecular docking simulations of compounds 1–7, the newly synthesised 1(2H)-phthalazinone derivatives with N-(dimethylamino)ethyl pendant arm, as potent inhibitors of HIV-1 protease (HIV-1 PR) were performed. The results of calculations show that c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4fbecb9f582a656963113faad4e2851d
https://doi.org/10.1080/08927022.2015.1067808
https://doi.org/10.1080/08927022.2015.1067808
Autor:
Jan Epsztajn, Zbigniew Malinowski, Aleksandra K. Szcześniak, Dariusz Sroczyński, Elzbieta Czarnecka, Wanda Pakulska
A series of new alkyl, tosyl, acetyl, and tert-butoxycarbonyl derivatives of 2-(2-aminoethyl)-phthalazinones were efficiently synthesized by reaction of lactams with N-Boc-, N-acetyl-, or N,O-ditosyl derivatives of N-methylethanolamine in the presenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76a0d253a6cf8daf7d19298d4e2a037c
Publikováno v:
ChemInform. 28
The synthesis of 3-substituted 2-phenyl-2,3-dihydro-4H-1,3,2-benzoxazaphosphorin-4-one 2-sulfide derivatives is described. The action of a series 2-oxide (1-6) and 2-sulfide (7-12) derivatives on the central nervous system has been evaluated. Compoun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e5335d74812dd34527de6580cbe4cbc
https://doi.org/10.1002/chin.199749191
https://doi.org/10.1002/chin.199749191
Autor:
Wanda, Pakulska, Elzbieta, Czarnecka
Publikováno v:
Acta poloniae pharmaceutica. 66(6)
Numerous methods of management applied in order to obtain higher therapeutic efficacy of drugs with minimum adverse effects include taking advantage of interactions taking place between individual agents. Analgesics are combined with drugs belonging
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4a9dfd9fa4c5ad2d2d8157ab473c35e7
https://pubmed.ncbi.nlm.nih.gov/20050537
https://pubmed.ncbi.nlm.nih.gov/20050537
Publikováno v:
Archiv der Pharmazie. 342(1)
New N-(dimethylamino)ethyl derivatives of phthalazinones and pyridopyridazinones 7, 9 were synthesized and assayed as potential analgesic agents in the hot-plate, tail-flick, and writhing tests. Pharmacological assay demonstrated that eight (in ten)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28875a892264aa66e113bf4a9897f82e
https://pubmed.ncbi.nlm.nih.gov/19051195
https://pubmed.ncbi.nlm.nih.gov/19051195
Autor:
Wanda, Pakulska
Publikováno v:
Acta poloniae pharmaceutica. 64(3)
The influence of tiagabine at a dose of 3.2 mg/kg (single administration) and at a dose of 1.2 mg/kg (multiple administration - 10 days) on the antinociceptive effect of morphine (10 mg/kg), metamizole (500 mg/kg) and indomethacin (10 mg/kg - single
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8ecd3796189f97031277acf0ac64e8ba
https://pubmed.ncbi.nlm.nih.gov/17695150
https://pubmed.ncbi.nlm.nih.gov/17695150
Autor:
Małgorzata, Dzielska-Olczak, Julita, Graczyk-Wojciechowska, Wanda, Pakulska, Remigiusz, Zieba
Publikováno v:
Acta poloniae pharmaceutica.
Doxorubicin (DOX) is an anthracycline antibiotic with a potent anticancer activity used against human neoplasms. Doxorubicin causes numerous adverse effects i.e., toxic effect on the cardiovascular system of experimental animals and humans. DOX may p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3d75d6e88704cd2a2349dd6e2c7fb159
https://pubmed.ncbi.nlm.nih.gov/15909940
https://pubmed.ncbi.nlm.nih.gov/15909940
Autor:
Wanda, Pakulska, Elzbieta, Czarnecka
Publikováno v:
Acta poloniae pharmaceutica. 61(5)
The effect of gabapentin at a dose of 10 mg/kg (single administration) and at 3 mg/kg/day (administered for 10 days) on the analgesic action of morphine (10 mg/kg), metamizol (500 mg/kg) and indomethacin (10 mg/kg and 1.4 mg/kg) in mice was assessed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ac6f0fd8b102fc8184415035917dca97
https://pubmed.ncbi.nlm.nih.gov/15747697
https://pubmed.ncbi.nlm.nih.gov/15747697
Autor:
Wanda, Pakulska
Publikováno v:
Acta poloniae pharmaceutica. 61(2)
Interaction between analgesic and various psychotropic drugs constitute a subject of many research investigations. Literature data considering this issue are often inconsistent. Sertraline is one of the most potent drugs in the family of selective se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::44239c800b6a66e7ff4288e82906f56c
https://pubmed.ncbi.nlm.nih.gov/15493299
https://pubmed.ncbi.nlm.nih.gov/15493299
Influence of felbamate on the antinociceptive action of morphine, metamizol and indomethacin in mice
Publikováno v:
Acta poloniae pharmaceutica. 60(3)
The influence of felbamate (200 mg/kg or 50 mg/kg) on antinociceptive effect of morphine (10 mg/kg), metamizol (500 mg/kg) and indomethacin (10 mg/kg or 1.4 mg/kg) was investigated in a mouse model using the hot-plate test. All drugs were injected in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8e4baf75f71f56081048fb6065ab80b8
https://pubmed.ncbi.nlm.nih.gov/14556489
https://pubmed.ncbi.nlm.nih.gov/14556489