The double bromodomain protein Brd2 promotes B cell expansion and mitogenesis

Autor: Barbara S. Nikolajczyk, Wanda P. Blanton, Gerald V. Denis, Anna C. Belkina

Publikováno v: Journal of Leukocyte Biology. 95:451-460

Bromodomain-containing transcriptional regulators represent new epigenetic targets in different hematologic malignancies. However, bromodomain-mediated mechanisms that couple histone acetylation to transcription in lymphopoiesis and govern mature lym

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cbd9239204f5d45a4c891f252eea1e3
https://doi.org/10.1189/jlb.1112588

Lead Authors and Contributors

Autor: Ivor J. Benjamin, Sara G. Tariq, Susan S. Beland, David Bull, Mohamed H. Hamdan, Dean Y. Li, Sheldon E. Litwin, Andrew D. Michaels, Jack H. Morshedzadeh, Josef Stehlik, Kevin J. Whitehead, Ronald G. Victor, Wanpen Vongpatanasin, Sharon I. Rounds, Jason M. Aliotta, Brian Casserly, Matthew D. Jankowich, F. Dennis McCool, Kim A. Eagle, Wei C. Lau, Raymond C. Harris, Thomas E. Andreoli, Amanda W. Basford, Kerri L. Cavanaugh, Jamie P. Dwyer, Thomas A. Golper, Michelle W. Krause, T. Alp Ikizler, Julia B. Lewis, James M. Luther, James L. Pirkle, Didier Portilla, Robert L. Safirstein, Gerald Schulman, Sudhir V. Shah, Roy Zent, M. Michael Wolfe, Wanda P. Blanton, Charles M. Bliss, Francis A. Farraye, Christopher S. Huang, Brian C. Jacobson, David R. Lichtenstein, Robert Lowe, Daniel S. Mishkin, T. Carlton Moore, Jaime A. Oviedo, Marcos C. Pedrosa, Elihu M. Schimmel, Paul C. Schroy, Satish K. Singh, Chi-Chuan Tseng, Michael B. Fallon, Miguel R. Arguedas, Rudolf Garcia-Gallont, Rajan Kochar, Brendan M. McGuire, Klaus Mönkemüller, Helmut Neumann, Aasim M. Sheikh, Shyam Varadarajulu, Nancy Berliner, Jill Lacy, Christine S. Rinder, Henry M. Rinder, Michal G. Rose, Stuart E. Seropian, Christopher Tormey, Richard Torres, Eunice S. Wang, Jennifer J. Griggs, Barbara A. Burtness, Alok A. Khorana, Paula M. Lantz, Robert F. Todd, Robert J. Smith, David G. Brooks, Geetha Gopalakrishnan, Osama Hamdy, Michelle P. Warren, Thomas R. Ziegler, Glenn D. Braunstein, Philip S. Barnett, Vivien S. Herman-Bonert, Theodore C. Friedman, Pamela A. Charney, Patricia I. Carney, Deborah B. Ehrenthal, Renee K. Kottenhahn, Joseph A. Smith, Douglas F. Milam, Johnathan S. Starkman, Andrew F. Stewart, Susan L. Greenspan, Steven P. Hodak, Mara J. Horwitz, Shane O. LeBeau, G. David Roodman, Larry W. Moreland, Surabhi Agarwal, Dana P. Ascherman, Robyn T. Domsic, Jennifer Rae Elliott, Amy H. Kao, Fotios Koumpouras, C. Kent Kwoh, Douglas W. Lienesch, Kathleen McKinnon-Maksimowicz, Thomas A. Medsger, Niveditha Mohan, Edward J. Wing, Keith B. Armitage, Curt G. Beckwith, David A. Bobak, Jessica K. Fairley, Scott A. Fulton, Corrilynn O. Hileman, Christoph Lange, Michael M. Lederman, Tracy L. Lemonovich, Michelle V. Lisagaris, Amy J. Ray, Benigno Rodriguez, Robert A. Salata, Richard R. Watkins, Robert W. Bradsher, Robert C. Griggs, Michel J. Berg, Emma Ciafaloni, Timothy J. Counihan, William P. Cheshire, Emily C. de los Reyes, Carlayne E. Jackson, Kevin A. Kerber, Lynn C. Liu, Geoffrey S.F. Ling, Jeffery M. Lyness, Deborah Joanne Lynn, Frederick J. Marshall, Allan McCarthy, Sinéad M. Murphy, Avindra Nath, E. Steve Roach, Lisa R. Rogers, Roger P. Simon, Harvey J. Cohen, Mitchell T. Heflin, Timothy E. Quill, Robert G. Holloway, L. David Hillis, Richard A. Lange

Publikováno v: Andreoli and Carpenter's Cecil Essentials of Medicine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::49024e4015718b56b85ba4ca9e6ca9d2
https://doi.org/10.1016/b978-1-4160-6109-0.00138-6

Brd2 disruption in mice causes severe obesity without Type 2 diabetes

Autor: Gerald V. Denis, Anna C. Belkina, Fangnian Wang, Wanda P. Blanton, Nathan K. LeBrasseur, Hongsheng Liu

Publikováno v: The Biochemical journal. 425(1)

Certain human subpopulations are metabolically healthy but obese, or metabolically obese but normal weight; such mutations uncouple obesity from glucose intolerance, revealing pathways implicated in Type 2 diabetes. Current searches for relevant gene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::602e1cc84494848a1b736c202457ae93
https://pubmed.ncbi.nlm.nih.gov/19883376

The Dual Bromodomain Protein Brd2 Controls Primary B Cell Mitogenesis and Cell Cycle in Mice Reconstituted with Lentivirus-Transduced HSCs

Autor: Gerald V. Denis, Douglas V. Faller, Fangnian Wang, Wanda P. Blanton, Paul B. Romesser, Hongsheng Liu

Publikováno v: Blood. 112:2465-2465

Transcriptional control of cellular proliferation and differentiation is critically important in hematopoiesis; specifically, the role of chromatin-dependent regulatory processes in this context is poorly understood. The human BRD2 proto-oncogene enc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5b2804e87b001cdc639e02ba659e38d2
https://doi.org/10.1182/blood.v112.11.2465.2465