Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Wanda Kwan"'
Autor:
Scarlett J Barker, Mai B Thayer, Chaeyoung Kim, David Tatarakis, Matthew Simon, Rebekah L Dial, Lizanne Nilewski, Robert C Wells, Yinhan Zhou, Megan Afetian, Alfred Chappell, Kylie S Chew, Johann Chow, Allisa Clemens, Claire B Discenza, Jason Dugas, Chrissa Dwyer, Timothy Earr, Connie Ha, David Huynh, Srini Jayaraman, Wanda Kwan, Cathal Mahon, Michelle Pizzo, Elysia Roche, Laura Sanders, Alexander Stergioulis, Raymond Tong, Hai Tran, Joy Zuchero, Anthony A Estrada, Kapil Gadkar, Christopher MM Koth, Pascal E Sanchez, Robert G Thorne, Ryan J Watts, Thomas Sandmann, Lesley Kane, Frank Rigo, Mark S Dennis, Joseph W Lewcock, Sarah L DeVos
Antisense oligonucleotides (ASO) are promising therapies for neurological disorders, though they are unable to cross the blood-brain barrier (BBB) and must be delivered directly to the central nervous system (CNS). Here, we use a human transferrin re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56046f97df89d6a2d15a721b2fca4f31
https://doi.org/10.1101/2023.04.25.538145
https://doi.org/10.1101/2023.04.25.538145
Autor:
Mauricio Cortes, Michael J. Chen, David L. Stachura, Sarah Y. Liu, Wanda Kwan, Francis Wright, Linda T. Vo, Lindsay N. Theodore, Virginie Esain, Isaura M. Frost, Thorsten M. Schlaeger, Wolfram Goessling, George Q. Daley, Trista E. North
Publikováno v:
Cell Reports, Vol 17, Iss 2, Pp 458-468 (2016)
Vitamin D insufficiency is a worldwide epidemic affecting billions of individuals, including pregnant women and children. Despite its high incidence, the impact of active vitamin D3 (1,25(OH)D3) on embryonic development beyond osteo-regulation remain
Externí odkaz:
https://doaj.org/article/c86ac4467ef9412db3c1c7c808d28080
Publikováno v:
Stem Cell Reports, Vol 5, Iss 4, Pp 471-479 (2015)
Hematopoietic stem and progenitor cells (HSPCs) are born from hemogenic endothelium in the dorsal aorta. Specification of this hematopoietic niche is regulated by a signaling axis using Hedgehog (Hh) and Notch, which culminates in expression of Runx1
Externí odkaz:
https://doaj.org/article/82e6771f4a694056a4c153b9ec0bdf7b
Autor:
Isaura M. Frost, Roger A. Rajewski, John H. Bushweller, Trista E. North, Charles Schmidt, Anuradha Illendula, Zaw Min Oo, Wanda Kwan, Yunpeng Zhou, Jolanta Grembecka, Virginie Esain, Nancy A. Speck
Publikováno v:
Leukemia & Lymphoma. 59:2188-2200
The core binding factor (CBF) gene RUNX1 is a target of chromosomal translocations in leukemia, including t(8;21) in acute myeloid leukemia (AML). Normal CBF function is essential for activity of AML1-ETO, product of the t(8;21), and for survival of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae6c9a8efff6ff1311ccec6a1b1578d9
https://doi.org/10.1080/10428194.2017.1410882
https://doi.org/10.1080/10428194.2017.1410882
Autor:
Sahar Nissim, Trista E. North, Lea Vedder Sheward, Wanda Kwan, Gregory M. Frechette, Virginie Esain, Kelli J. Carroll, Sarah Y. Liu, Wolfram Goessling, Mauricio Cortes
Publikováno v:
Stem Cells. 33:2596-2612
Cannabinoids (CB) modulate adult hematopoietic stem and progenitor cell (HSPCs) function, however, impact on the production, expansion, or migration of embryonic HSCs is currently uncharacterized. Here, using chemical and genetic approaches targeting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbda1b2b21ffa8092d93b1a778a04db9
https://doi.org/10.1002/stem.2044
https://doi.org/10.1002/stem.2044
Autor:
Wanda, Kwan, Trista E, North
Publikováno v:
Current topics in developmental biology. 124
Zebrafish are one of the preeminent model systems for the study of blood development (hematopoiesis), hematopoietic stem and progenitor cell (HSPC) biology, and hematopathology. The zebrafish hematopoietic system shares strong similarities in functio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5f1bee9b3a6f7a4d512b6cd8eefe907b
https://pubmed.ncbi.nlm.nih.gov/28335858
https://pubmed.ncbi.nlm.nih.gov/28335858
Autor:
Trista E. North, Wanda Kwan
Zebrafish are one of the preeminent model systems for the study of blood development (hematopoiesis), hematopoietic stem and progenitor cell (HSPC) biology, and hematopathology. The zebrafish hematopoietic system shares strong similarities in functio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7c64dc0e4e281661ebf71e0d6de267b
https://doi.org/10.1016/bs.ctdb.2016.11.005
https://doi.org/10.1016/bs.ctdb.2016.11.005
Autor:
Wanda Kwan, Isaura M. Frost, Mauricio Cortes, Kai Tan, Joanna Tober, Virginie Esain, Marijke W. Maijenburg, Trista E. North, Elaine Dzierzak, Xiongwei Cai, Nancy A. Speck, Stuart H. Orkin, Li Teng, Yan Li, Amanda D. Yzaguirre, Jian Xu
Publikováno v:
Genes & Development, 28(23), 2597-2612. Cold Spring Harbor Laboratory Press
Li, Y, Esain, V, Teng, L, Xu, J, Kwan, W, Frost, I M, Yzaguirre, A D, Cai, X, Cortes, M, Maijenburg, M W, Tober, J, Dzierzak, E, Orkin, S H, Tan, K, North, T E & Speck, N A 2014, ' Inflammatory signaling regulates embryonic hematopoietic stem and progenitor cell production ', Genes & Development, vol. 28, no. 23, pp. 2597-612 . https://doi.org/10.1101/gad.253302.114
Li, Y, Esain, V, Teng, L, Xu, J, Kwan, W, Frost, I M, Yzaguirre, A D, Cai, X, Cortes, M, Maijenburg, M W, Tober, J, Dzierzak, E, Orkin, S H, Tan, K, North, T E & Speck, N A 2014, ' Inflammatory signaling regulates embryonic hematopoietic stem and progenitor cell production ', Genes & Development, vol. 28, no. 23, pp. 2597-612 . https://doi.org/10.1101/gad.253302.114
Identifying signaling pathways that regulate hematopoietic stem and progenitor cell (HSPC) formation in the embryo will guide efforts to produce and expand HSPCs ex vivo. Here we show that sterile tonic inflammatory signaling regulates embryonic HSPC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bb54b0b85e4bc4dfd75ee02e25afbc6
https://doi.org/10.1101/gad.253302.114
https://doi.org/10.1101/gad.253302.114
Autor:
Michael C Dovey, Mauricio Cortes, Kelli J. Carroll, Gregory M. Frechette, Virginie Esain, Sahar Nissim, Trista E. North, Maija K. Garnaas, Nathan D. Lawson, Wolfram Goessling, Wanda Kwan, James M. Harris, Sarah Y. Liu, Marnie E. Halpern, Daniel A. Gorelick, Claire C. Cutting
Publikováno v:
Developmental Cell. 29:437-453
The genetic control of hematopoietic stem and progenitor cell (HSPC) function is increasingly understood, however less is known about the interactions specifying the embryonic hematopoietic niche. Here, we report 17β-estradiol (E2) influences the pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2185620d9bb2d5fe4120e492af6e9076
https://doi.org/10.1016/j.devcel.2014.04.012
https://doi.org/10.1016/j.devcel.2014.04.012
Autor:
Mauricio Cortes, Trista E. North, Virginie Esain, Sarah Y. Liu, Nadine Budrow, Isaura M. Frost, Wolfram Goessling, Wanda Kwan, Lindsay N. Theodore
Hematopoietic stem and progenitor cell (HSPC) specification is regulated by numerous defined factors acting locally within the hemogenic niche, however, it is unclear whether production can adapt to fluctuating systemic needs. Here, we show the centr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd1fa79ee71422bde44beea9e67feda8
https://europepmc.org/articles/PMC5181112/
https://europepmc.org/articles/PMC5181112/