Efficacy of catheter-based renal denervation in the absence of antihypertensive medications (SPYRAL HTN-OFF MED Pivotal): a multicentre, randomised, sham-controlled trial

Autor: Yale Wang, Matthaios Didangelos, John Kotter, Christopher Bell, Perwaiz Meraj, Naing Moore, Shaun Selcer, Samer Kazziha, Fidel Garcia, Neha J. Pagidipati, Ashley Meade, Benjamin Blossom, Kota Komiyama, Walter H. Haught, Marat Fudim, Markus Suppan, A.M. Gutiérrez, Chandan Devireddy, Karl Philipp Rommel, Thomas C. Wright, Ronan Cusack, Daniel Keene, Richard D'Souza, Jayant Khitha, Fued Jan, Joshua Krasnow, Magdi Ghali, James W. Choi, Kiritkumar Patel, Santiago Garcia, Fumiko Mori, Joachim Weil, Peggy Hardesty, Kai Ninomiya, Michael Böhm, Kengo Tanabe, Christian Binner, Thomas Dienemann, Kristina Striepe, Somjot S Brar, Michael Remetz, Shi Chi Cheng, Robert E. Burke, Valentin Fuster, Shannon Lynch, Vanessa DeBruin, Tim O'Connor, Aravinda Nanjundappa, Kazuyuki Yahagi, Alex Garton, Rajiv Jauhar, David Rizik, Monique Robison, Wendy Porr, Craig Chasen, Sayan Sen, Stuart J. Pocock, Sreekanth Vemulapalli, Philipp Lurz, Phillip Hartung, Udo Desch, Nishit Choksi, Neil Chapman, Adrian Ma, Anjani Rao, Marc A. Lavoie, Janice P. Lea, Shukri David, Taisei Kobayashi, Robert S. Schwartz, William J. Calhoun, Tony Walton, John Estess, Theodoros Kalos, Avneet Singh, Tetsu Tanaka, Robert L. Wilensky, Cara East, Sandeep Brar, Katie McDuffie, Jasvindar Singh, James R. Murphy, Robert Wilkins, Antonios Ziakas, Beth Chia, Jordana B. Cohen, Samit Shah, Debbie L. Cohen, Wolfgang Helmreich, Jason Stuck, Masahiko Asami, Satoshi Hoshide, Sarah Statton, Yusuke Oba, Sarwan Kumar, Lucas Lauder, Yukiyo Ogata, Thomas Zeller, Alejandro Arias Vasquez, Yu Horiuchi, Susanne Jung, Tolga Agdirlioglu, Matthew G. Denker, David Reyes, Denise Reedus, Jay H. Traverse, Sidney Cohen, George Soliman, Mehdi H. Shishehbor, Douglas Hill, Yukako Ogoyama, Faisal Sharif, Matthew J. Shun-Shin, Martin N. Burke, Yassir Sirajeldin, Saarraangan Kulenthiran, Elena Linesky, Hirotaka Waki, Niall Connolly, Dominic Millenaar, Yvonne Bewarder, Sabino Torre, David E. Kandzari, Carl Lomboy, Desmond Jay, Rabia Razi, Christian Ott, William Bachinsky, Roland E. Schmieder, Thomas Weber, Bryan Wells, Konstantinos Tsioufis, John H. Barton, George Dangas, Philippe L. L’Allier, Bimal Padaliya, Bharat Gummadi, Jacqueline Sennott, Antonios Kouparanis, Johanna Contreras, Bryan Batson, Jason Bloom, James P. Howard, Douglas Shemin, Sara Hays, Kyle Bass, Mihar Kanitkar, Liesbeth Rosseel, Nedaa Skeik, James Campbell, Juliane Dederer, Brent T. McLaurin, Steve Carroll, Marcos Rothstein, Emanouela Petteinidou, Jean François Dorval, Souhell Saba, David A. Zidar, Thomas Johnston, Axel Schmid, Randolph Rough, Phillip Munch, Masahisa Shimpo, Hayato Shimizu, James R. Johnson, Alan C. Yeung, Brian K. Jefferson, Karl Bihlmaier, Dimitris Konstantinidis, Felix Mahfoud, Francisco Sierra, Raymond R. Townsend, Kazuomi Kario, Jose M. Saavedra, Suhail Allaqaband, Carl Gessler, Jennifer M. Murray, Ingrid Hopper, Wanda Ikeda, Crystal C. Tyson, Ertan Akarca, Ray Zadegan, Jelena Lucic, Ahran D. Arnold, Laura P. Svetkey, Matthias Lerche, Ganpat Takker, Christopher Regan, Dennis Kannenkeril, Enrique Velasquez, Martin Fahy, Kyriakos Dimitriadis, Justin E. Davies, Yonghong Haun, Takahiro Komori, David P. Lee, Hosei Kikushima, Rachel Onsrud, Jiro Aoki, Eirini Andrikou, Sebastian Ewen, Susan Steigerwalt, Khaled M. Ziada, Amit Gupta, Herbert D. Aronow, Michael Butler, Phillip Laney, Michael A. Weber, Andrew S.P. Sharp, Schuyler Jones, Manesh R. Patel, Prakash Mansukhani, Daijiro Tomii, Lee Ferguson, Karl Fengler, Julia Stehli, Brian McGrath, Nelson Little, Ramin Shadman, Barry Bertolet, Sarah Fan, Alexandros Kasiakogias, Angela L. Brown

Publikováno v: Lancet (London, England). 395(10234)

Summary Background Catheter-based renal denervation has significantly reduced blood pressure in previous studies. Following a positive pilot trial, the SPYRAL HTN-OFF MED (SPYRAL Pivotal) trial was designed to assess the efficacy of renal denervation

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https://pubmed.ncbi.nlm.nih.gov/35332472