Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Wanda E. Filipiak"'
Autor:
Christopher J. Sinal, Hannah Garver, Thomas L. Saunders, Elizabeth D. Hughes, David J. Ferland, Michael G. Zeidler, Emma S. Darios, Wanda E. Filipiak, Nichole McMullen, Ramya K. Kumar, Adam E. Mullick, Gregory D. Fink, Stephanie W. Watts
Publikováno v:
The FASEB Journal. 32:6596-6614
Measures of the adipokine chemerin are elevated in multiple cardiovascular diseases, including hypertension, but little mechanistic work has been done to implicate chemerin as being causative in such diseases. The chemerin knockout (KO) rat was creat
Autor:
Wanda E, Filipiak, Elizabeth D, Hughes, Galina B, Gavrilina, Anna K, LaForest, Thomas L, Saunders
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2018
The next generation of new genetically engineered rat models by microinjection is described. Genome editors such as CRISPR/Cas9 have greatly increased the efficiency with which the rat genome can be modified to generate research models for biomedical
Autor:
Anna K LaForest, Wanda E. Filipiak, Galina B. Gavrilina, Elizabeth D. Hughes, Thomas L. Saunders
Publikováno v:
Methods in Molecular Biology ISBN: 9781493995806
The next generation of new genetically engineered rat models by microinjection is described. Genome editors such as CRISPR/Cas9 have greatly increased the efficiency with which the rat genome can be modified to generate research models for biomedical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0382c14c1cba45a3506dc784015ec539
https://doi.org/10.1007/978-1-4939-9581-3_4
https://doi.org/10.1007/978-1-4939-9581-3_4
Autor:
Elizabeth D. Hughes, Thomas L. Saunders, Joshua D. Berke, Wanda E. Filipiak, Rifka C. Derman, Jeffrey R. Pettibone, Jai Y. Yu, Michael G. Zeidler, Carrie R. Ferrario
Publikováno v:
eNeuro
eNeuro, vol 6, iss 5
eNeuro, vol 6, iss 5
Genetically modified mice have become standard tools in neuroscience research. Our understanding of the basal ganglia in particular has been greatly assisted by BAC mutants with selective transgene expression in striatal neurons forming the direct or
Autor:
Thomas L. Saunders, Eric E. Morgan, Sivarajan Kumarasamy, Amira F. Gohara, Bina Joe, Surya M. Nauli, Shakila Abdul-Majeed, Wanda E. Filipiak, Andrea Kalinoski, Kathirvel Gopalakrishnan
Publikováno v:
Proceedings of the National Academy of Sciences. 109:20555-20559
A disintegrin-like metalloproteinase with thrombospondin motifs–16 ( Adamts16 ) is an important candidate gene for hypertension. The goal of the present study was to further assess the candidacy of Adamts16 by targeted disruption of this gene in a
Autor:
Shondra Miller, Harshal Waghulde, Thomas L. Saunders, Wanda E. Filipiak, Xi Cheng, Blair Mell, Bina Joe
Publikováno v:
Hypertension. 68
This study is focused on a GWAS locus for cardiovascular disease (QT-interval) on human chromosome 17. The homologous genomic segment of this human locus was previously mapped with high resolution to
Autor:
Leah M. Wuescher, Manish Karamchandani, Sivarajan Kumarasamy, Siddhi Upadhyaya, Thomas L. Saunders, Joseph I. Shapiro, Stanislaw M. Stepkowski, Steven T. Haller, Jiang Tian, Kyle Maxwell, Christopher J. Cooper, David A Folt, Harshal Waghulde, Bina Joe, Wanda E. Filipiak, Christopher A. Drummond, Blair Mell, Muhammad A. Chaudhry
Publikováno v:
Kidney international. 91(2)
High blood pressure is a common cause of chronic kidney disease. Because CD40, a member of the tumor necrosis factor receptor family, has been linked to the progression of kidney disease in ischemic nephropathy, we studied the role of Cd40 in the dev
Publikováno v:
The FASEB Journal. 29
High resolution mapping of a human cardiovascular locus (QT-interval) in the homologous genomic segment spanning
Autor:
Frank C. Brosius, Thomas L. Saunders, Kathleen A. Burke, Minghui Xiang, Hongyu Zhang, Wanda E. Filipiak, Jharna Saha, Mary Lee A. Schin, Lawrence B. Holzman, Charles W. Heilig
Publikováno v:
American journal of physiology. Renal physiology. 299(1)
Increased expression of the facilitative glucose transporter, GLUT1, leads to glomerulopathy that resembles diabetic nephropathy, whereas prevention of enhanced GLUT1 expression retards nephropathy. While many of the GLUT1-mediated effects are likely
Autor:
Galina B. Gavrilina, Margaret L. Van Keuren, Thomas L. Saunders, Wanda E. Filipiak, Michael G. Zeidler
Publikováno v:
Transgenic research. 18(5)
Transgenic mice are widely used in biomedical research to study gene expression, developmental biology, and gene therapy models. Bacterial artificial chromosome (BAC) transgenes direct gene expression at physiological levels with the same development