Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Wanda DePinto"'
Autor:
Krishna E. Tobón, Jim Rosinski, Paul Delmar, John F. Reidhaar-Olson, Mark DeMario, Tri Quang Nguyen, Steve R. Ritland, Ruediger Rueger, Patricia Mcloughlin, Wanda DePinto, Charu Kanwal, Holly Hilton, Windy Berkofsky-Fessler, Juliette Molnos
Publikováno v:
Molecular Cancer Therapeutics. 8:2517-2525
A genomics-based approach to identify pharmacodynamic biomarkers was used for a cyclin-dependent kinase inhibitory drug. R547 is a potent cyclin-dependent kinase inhibitor with a potent antiproliferative effect at pharmacologically relevant doses and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28598b1fe1971e6f7242a662fc54b428
https://doi.org/10.1158/1535-7163.mct-09-0083
https://doi.org/10.1158/1535-7163.mct-09-0083
Autor:
Sazzad Hussain, Brian Higgins, Packman Kathryn E, Bernardo Felix, Hong Qian, Tom Nevins, Kenneth Kolinsky, Yingsi Chen, Roger Blain, David C. Heimbrook, Allen John Lovey, Wanda DePinto, Christian Tovar, Melissa Smith, Petra Goelzer, Xuefeng Yin, Leopoldo Luistro, Xin-Jie Chu, Qing Xiang, Rachid Hamid
Publikováno v:
Molecular Cancer Therapeutics. 5:2644-2658
The cyclin-dependent protein kinases are key regulators of cell cycle progression. Aberrant expression or altered activity of distinct cyclin-dependent kinase (CDK) complexes results in escape of cells from cell cycle control, leading to unrestricted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9674b1d60dd3411af49528aad073369e
https://doi.org/10.1158/1535-7163.mct-06-0355
https://doi.org/10.1158/1535-7163.mct-06-0355
Autor:
John Anthony Moliterni, David Joseph Bartkovitz, Ka Wang, Xuefeng Yin, Nader Fotouhi, Allen John Lovey, Petra Goelzer, Binh Thanh Vu, Packman Kathryn E, Xin-Jie Chu, Qing Xiang, Nan Jiang, Melissa Smith, Christine Lukacs, Qingjie Ding, Brian Higgins, Wanda DePinto, Sung-Sau So, Yingsi Chen, Kaplan Gerald Lewis, Bradford Graves
Publikováno v:
Journal of Medicinal Chemistry. 49:6549-6560
The cyclin-dependent kinases (CDKs) and their cyclin partners are key regulators of the cell cycle. Since deregulation of CDKs is found with high frequency in many human cancer cells, pharmacological inhibition of CDKs with small molecules has the po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eef4e0f0b7f5af99d217c4cf21f6d76d
https://doi.org/10.1021/jm0606138
https://doi.org/10.1021/jm0606138
Autor:
Fred Konzelmann, Yingsi Chen, A. Schutt, Hong Yang, Ursula Kammlott, Yi Chen, Mary Simcox, Wanda DePinto, Kin-Chun Luk, Christine Lukacs, Jin-Jun Liu, Apostolos Dermatakis, Xuefeng Yin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:2465-2468
A novel class of 3,5,6-trisubstituted naphthostyril analogues was designed and synthesized to study the structure-activity relationship for inhibition of cyclin-dependent kinase 2 (CDK2). These compounds, particularly molecules with side-chain modifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00e32296701ef4302b5a96e50deac0b9
https://doi.org/10.1016/s0960-894x(03)00488-8
https://doi.org/10.1016/s0960-894x(03)00488-8
Publikováno v:
Bioorganicmedicinal chemistry. 11(8)
A series of oxindole CDK2 inhibitors was synthesized. These novel analogues have a saturated monosubstituted cyclic moiety at their C-4 position that mimics the ribofuranoside of ATP. This substitution afforded agents with increased potency relative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20f363cd429f9b7c13a875cf95f06a19
https://pubmed.ncbi.nlm.nih.gov/12659774
https://pubmed.ncbi.nlm.nih.gov/12659774
Autor:
Nichole Giles, Brian Gabrielli, Wanda DePinto, Andrew Burgess, Matthew Wigan, Paul Gillespie, Frankie Stevens
Publikováno v:
Melanoma Research. 16:S5
Cyclin-dependent kinase 4 (CDK4)/cyclin D has a key role in regulating progression through late G(1) into S phase of the cell cycle. CDK4-cyclin D complexes then persist through the latter phases of the cell cycle, although little is known about thei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b80181f146d5246d4fb8f5f6b20ef5a8
https://doi.org/10.1097/00008390-200609001-00006
https://doi.org/10.1097/00008390-200609001-00006