Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Wanda Chan"'
Autor:
Patricia Aoun, Adam Cloe, Karl Gaal, Saba Fatima Ali, Michelle Afkhami, Dennis D. Weisenburger, Young S. Kim, Evan Himchak, Joo Y. Song, Elizabeth Quirk, Parwiz J Siaghani, Wanda Chan, David Cantu, Raju Pillai
Publikováno v:
American journal of clinical pathology. 157(4)
Objectives Bone marrow collections are often difficult, and creating quality smears and touch preparations at the bedside can prove challenging. The objective of this study is to compare the quality of bone marrow specimens between unassisted and ass
Autor:
Susan P. Rohrer, Edward C. Hayes, Paula M.D. Fitzgerald, Yi Tien Yang, Carolyn DaSilva, Lee-Yuh Pai, Elizabeth T. Birzin, Frank P. DiNinno, Milton L. Hammond, Ralph T. Mosley, Wanda Chan, Liangqin Guo, James M. Schaeffer, Kevin D. Dykstra, Bryan Kraker
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:2322-2328
A novel class of indole ligands for estrogen receptor alpha have been discovered which exhibit potent affinity and high selectivity. Substitution of the bazedoxifene skeleton to the linker present in the HTS lead 1a provided 22b which was found to be
Autor:
Nandini Sharma, Consuelo Tudela, Milton L. Hammond, Fang Chen, Jerry D. Morgan, Timothy A. Blizzard, Susan P. Rohrer, Mark A. Holmes, Ralph Troy Mosley, Wanda Chan, Bryan Kraker, Candido Gude, Marina Mojena, Kristin Knecht, Qin Su, Paula M.D. Fitzgerald, Elizabeth T. Birzin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:834-838
A series of 19-substituted androstenediol derivatives was prepared. Some of the novel analogs were surprisingly potent and selective ligands for ER-beta.
Autor:
Lee-Yuh Pai, Carolyn DaSilva, Yi Tien Yang, Elizabeth T. Birzin, Ralph T. Mosley, Timothy A. Blizzard, Jerry D. Morgan, Frank P. DiNinno, Edward C. Hayes, Susan P. Rohrer, Milton L. Hammond, Wanda Chan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:5124-5128
Two novel side chains which had previously been found to enhance antagonist activity in the dihydrobenzoxathiin SERM series were applied to three existing platforms. The novel side chains did not improve the antagonist activity of the existing platfo
Autor:
Donald B. Kimmel, Lee Yuh Pai, Carolyn DaSilva, Paula M.D. Fitzgerald, Nandini Sharma, Alfred A. Reszka, Wanda Chan, Milton L. Hammond, Elizabeth T. Birzin, Yi Tien Yang, Lawrence F. Colwell, Susan Li, Hilary A. Wilkinson, Sharon Adamski, Qiang Tan, Jerry D. Morgan, Leonard P. Freedman, Edward C. Hayes, James M. Schaeffer, John E. Fisher, Susan P. Rohrer, Timothy A. Blizzard, Frank P. DiNinno, Sudha Warrier, Joel B. Yudkovitz
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:1675-1681
The discovery, synthesis, and SAR of chromanes as ERα subtype selective ligands are described. X-ray studies revealed that the origin of the ERα-selectivity resulted from a C-4 trans methyl substitution to the cis-2,3-diphenyl-chromane platform. Se
Autor:
Wanda Chan, Elizabeth T. Birzin, Lee-Yuh Pai, James M. Schaeffer, Edward C. Hayes, Carolyn DaSilva, Susan P. Rohrer, Yi Tien Yang, Frank P. DiNinno, Milton L. Hammond, Jian Liu, Ralph T. Mosley
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:715-718
The ring oxygen and sulfur analogs of lasofoxifene, 1a and 1b, were synthesized in an attempt to impart ERα selectivity, as found in the closely related dihydrobenzoxathiin compound I, recently discovered in these laboratories. The resulting isochro
Autor:
Frank P. DiNinno, Milton L. Hammond, James M. Schaeffer, Paula M.D. Fitzgerald, Zhoupeng Zhang, Edward C. Hayes, Wanda Chan, Timothy A. Blizzard, Elizabeth T. Birzin, Nandini Sharma, Carolyn DaSilva, Ying Li, Seongkon Kim, Wei Tang, Yi Tien Yang, Jane Y. Wu, Helen Chen, Susan P. Rohrer, Jerry D. Morgan, Lee-Yuh Pai
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:107-113
A series of dihydrobenzoxathiin SERAMs with alkylated pyrrolidine side chains or alkylated linkers was prepared. Minor modifications in the side chain or linker resulted in significant effects on biological activity, especially in uterine tissue.
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:1317-1321
A series of 2-phenylspiroindenediones was prepared. The spiroindenediones were found to be less active than the corresponding spiroindenes as estrogen receptor ligands and failed to demonstrate the receptor subtype selectivity that had been anticipat
Autor:
Todd Smith, Susan P. Rohrer, Marc Ferrer, Tim A. Blizzard, James M. Schaeffer, Berta Strulovici, Ira Hoffman, Paul A. Fischer, James Inglese, Norbert T. Peekhaus, Tina Chang, Wanda Chan, Jonathan Schneeweis, Elizabeth T. Birzin, Oleg Kornienko, Jayne Chin, Lyndon J. Mitnaul
Publikováno v:
ASSAY and Drug Development Technologies. 1:789-800
Estrogen action is mediated via two estrogen receptor (ER) subtypes, ERalpha and ERbeta. Selective ER modulators with balanced high affinity for ERalpha and ERbeta have been developed as therapeutics for the treatment of a variety of diseases, includ
Autor:
Klaus D. Schleim, Roy G. Smith, Kristine Prendergast, Lihu Yang, Wanda Chan, Arthur A. Patchett, Greg Morriello, Thomas M. Jacks, Kang Cheng
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 8:107-112
Systematic SAR studies of the different regioisomers and homologues of the spiro(indane-1,4-piperidine) moiety in the growth hormone secretagogue L-162,752 are presented. Among them, spiro(3H-1-benzopyran-2,3-piperidine) was found to afford secretago