Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Wanbin Fu"'
Publikováno v:
Hematology, Vol 29, Iss 1 (2024)
Objectives The TP53 mutation, a prevalent tumor suppressor gene alteration, is linked to chemotherapy resistance, increased relapse rates and diminished overall survival (OS) in acute myeloid leukemia (AML) patients.Methods In this study, we characte
Externí odkaz:
https://doaj.org/article/c21c1b2a07df4ed8a0ca3e1b1a9cdf34
Autor:
Wanbin Fu, Gelan Zhu, Lan Xu, Jia Liu, Xiaofeng Han, Junying Wang, Xinpeng Wang, Jian Hou, Huanbin Zhao, Hua Zhong
Publikováno v:
Cancer Cell International, Vol 22, Iss 1, Pp 1-10 (2022)
Abstract Background Arsenic trioxide (ATO) is highly effective in acute promyelocytic leukemia (APL) patients, but it fails to show satisfactory efficacy in other acute myeloid leukemia (AML) patients with non-APL subtypes. Different from the APL cel
Externí odkaz:
https://doaj.org/article/0ff84b10704849a0a9d84dfb2c1d627f
Publikováno v:
Journal of Hematology & Oncology, Vol 9, Iss 1, Pp 1-4 (2016)
Abstract We demonstrate the synergistic antitumor effect of oridonin and the PI3K/mTOR inhibitor NVP-BEZ235 on the non-germinal center B cell-like subtype of diffuse large B cell lymphoma (non-GCB DLBCL) both in vitro and in vivo. The underlying mech
Externí odkaz:
https://doaj.org/article/a68f4a39eaa24c7f8b29744c4dfb6b14
Autor:
Wenjing Lang, Lan Xu, Zilong Qiu, Fangyuan Chen, Honghui Huang, Jiayi Cai, Xiaoli Hu, Hua Zhong, Wanbin Fu
Publikováno v:
Journal of Oncology
Journal of Oncology, Vol 2021 (2021)
Journal of Oncology, Vol 2021 (2021)
FMS-like tyrosine kinase 3 (FLT3) mutant acute myeloid leukemia (AML) occurs in approximately 30% of all AML patients and still has a poor prognosis. This study is directed to investigate gilteritinib in combination with homoharringtonine (HHT) on FL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ead0bd931988024e2c6bc56fc2d78d3
https://pubmed.ncbi.nlm.nih.gov/34594375
https://pubmed.ncbi.nlm.nih.gov/34594375
Publikováno v:
The Journal of Agricultural Science. 156:358-366
Cucumber powdery mildew is a destructive foliar disease caused by Podosphaera xanthii (formerly known as Sphaerotheca fuliginea) that substantially damages the yield and quality of crops. The control of this disease primarily involves the use of chem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a20fa98911150714fa7499e7ddda6fe7
https://doi.org/10.1017/s0021859618000345
https://doi.org/10.1017/s0021859618000345
Autor:
Hua Zhong, Huanbin Zhao, Xinpeng Wang, Wanbin Fu, Xiaofeng Han, Junying Wang, Lan Xu, Jia Liu, Jiong Hu, Jian Hou
Publikováno v:
Blood. 138:4338-4338
Arsenic trioxide (ATO) is the first-line drug for the treatment of acute promyelocytic leukemia (APL). Aquaporin-9 (AQP9), a transmembrane transporter, is required for leukemia cells to uptake ATO. APL cells express high levels of AQP9, while other t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c729ee9997e7a08dbe2a616b7e61b44
https://doi.org/10.1182/blood-2021-149973
https://doi.org/10.1182/blood-2021-149973
Co-treatment triggered ROS generation which mediated non-GCB DLBCL cell apoptosis. (A) Cell lines were simultaneously treated with oridonin (2 μM) and NVP-BEZ235 (25 nM) for 48 h, FACS quantitative analysis of DCF-DA was used to detect ROS with t te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9623db00f66f907efb5ca47ff5d0ae97
Combination effects of oridonin and NVP-BEZ235 on proliferation inhibition. (A) Cell viability of OCI-Ly3, SU-DHL-2 was measured by CCK-8 assay after treated with oridonin (2 μM) and NVP-BEZ235 (25 nM) alone or in combination for 48 h. Drugs were co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89a029ae79add7666b4f53365f0bc21e
Oridonin combined with NVP-BEZ235 significantly increased the apoptosis on non-GCB DLBCL cell lines. (A, B) Cell lines were simultaneously treated with oridonin (2 μM) and NVP-BEZ235 (25 nM) for 24 and 48 h, analyzing apoptosis by Annexin-V/PI stain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::129a1736062ed0fd3fd6c7fd513ccc95
Materials and methods. (PDF 106 kb)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::797247fa84e2904583fec236f4f14f23