Zobrazeno 1 - 10
of 512
pro vyhledávání: '"WanJin Hong"'
Autor:
Gisela Armada, Susana Roque, Cláudia Serre-Miranda, Liliana Ferreira, Ana Vale, Ana João Rodrigues, Wanjin Hong, Margarida Correia-Neves, Neide Vieira
Publikováno v:
Neurobiology of Stress, Vol 30, Iss , Pp 100619- (2024)
Sorting Nexin 27 (SNX27) is a brain-enriched endosome-associated cargo adaptor that shapes excitatory control, being relevant for cognitive and reward processing, and for several neurological conditions. Despite this, SNX27's role in the nervous syst
Externí odkaz:
https://doaj.org/article/152aaf11cebe493d887be6e35d77155c
Autor:
Yang Han, Xiaoqing Liu, Liju Xu, Ziheng Wei, Yueting Gu, Yandan Ren, Wenyi Hua, Yongtao Zhang, Xiaoxi Liu, Cong Jiang, Ruijuan Zhuang, Wanjin Hong, Tuanlao Wang
Publikováno v:
Cells, Vol 13, Iss 16, p 1313 (2024)
Endoplasmic reticulum (ER)–endolysosome interactions regulate cholesterol exchange between the ER and the endolysosome. ER–endolysosome membrane contact sites mediate the ER–endolysosome interaction. VAP-ORP1L (vesicle-associated membrane prote
Externí odkaz:
https://doaj.org/article/d5282c6d97c14bd3b75fbc7ce7b418e0
Autor:
Ramesh Kumar, Wanjin Hong
Publikováno v:
Cells, Vol 13, Iss 7, p 564 (2024)
Originally identified in Drosophila melanogaster in 1995, the Hippo signaling pathway plays a pivotal role in organ size control and tumor suppression by inhibiting proliferation and promoting apoptosis. Large tumor suppressors 1 and 2 (LATS1/2) dire
Externí odkaz:
https://doaj.org/article/0f2cebdc79de4ea498d651abf4ae6735
SPTAN1/NUMB axis senses cell density to restrain cell growth and oncogenesis through Hippo signaling
Autor:
Dongxue Su, Yuxi Li, Weiji Zhang, Huan Gao, Yao Cheng, Yongqiang Hou, Junhong Li, Yi Ye, Zhangjian Lai, Zhe Li, Haitao Huang, Jiaxin Li, Jinhuan Li, Mengyu Cheng, Cheng Nian, Na Wu, Zhien Zhou, Yunzhi Xing, Yu Zhao, He Liu, Jiayu Tang, Qinghua Chen, Lixin Hong, Wengang Li, Zhihai Peng, Bin Zhao, Randy L. Johnson, Pingguo Liu, Wanjin Hong, Lanfen Chen, Dawang Zhou
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 20 (2023)
The loss of contact inhibition is a key step during carcinogenesis. The Hippo–Yes-associated protein (Hippo/YAP) pathway is an important regulator of cell growth in a cell density–dependent manner. However, how Hippo signaling senses cell density
Externí odkaz:
https://doaj.org/article/10851ccf1c0d4b83bc5cb1bf57cbefc0
Autor:
Ruijuan Zhuang, Yuxia Zhou, Ziyan Wang, Yating Cao, Jun Chen, Liju Xu, Yandan Ren, Yige Zheng, Ziheng Wei, Hantian Qiu, Liangcheng Li, Yang Han, Ye Yun, Xin Chen, Wanjin Hong, Tuanlao Wang
Publikováno v:
PLoS Biology, Vol 21, Iss 6, p e3002142 (2023)
Rab26 is known to regulate multiple membrane trafficking events, but its role in insulin secretion in pancreatic β cells remains unclear despite it was first identified in the pancreas. In this study, we generated Rab26-/- mice through CRISPR/Cas9 t
Externí odkaz:
https://doaj.org/article/50ab4331ce804b418c14a1d14646b0f4
Autor:
Yuegui Guo, Zhehui Zhu, Zhenyu Huang, Long Cui, Wei Yu, Wanjin Hong, Zhaocai Zhou, Peng Du, Chen-Ying Liu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Hippo signalling is often deregulated in cancers. Here the authors show that CK2 enhances the cooperation of HHEX with YAP-TEAD complex to promote colorectal tumorigenesis.
Externí odkaz:
https://doaj.org/article/d618908aad7044e49433c6f1f82f84b6
Autor:
Cunjie Chang, Muthukumar Rajasekaran, Yiting Qiao, Heng Dong, Yu Wang, Hongping Xia, Amudha Deivasigamani, Minjie Wu, Karthik Sekar, Hengjun Gao, Mengqing Sun, Yuqin Niu, Qian Li, Lin Tao, Zhen Yan, Menglan Wang, Shasha Chen, Shujuan Zhao, Dajing Chen, Lina Li, Fan Yang, Haojin Gao, Baodong Chen, Ling Su, Liang Xu, Ye Chen, Veerabrahma Pratap Seshachalam, Gongxing Chen, Jayantha Gunaratne, Wanjin Hong, Junping Shi, Gongying Chen, David S. Grierson, Benoit Chabot, Tian Xie, Kam Man Hui, Jianxiang Chen
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Alternative splicing is dysregulated in hepatocellular carcinoma. Here, the authors investigate the role of the splice variant of Splicing Regulatory Glutamic Acid and Lysine Rich Protein 1 (SREK1) and its upstream regulator, Serine/arginine-rich spl
Externí odkaz:
https://doaj.org/article/899e96a6dffd4ad49c98b29c783e660e
Autor:
Jicheng Yang, Fusheng Guo, Hui San Chin, Gao Bin Chen, Chow Hiang Ang, Qingsong Lin, Wanjin Hong, Nai Yang Fu
Publikováno v:
Cell Reports, Vol 42, Iss 2, Pp 112065- (2023)
Summary: Tetraspanins, a superfamily of membrane proteins, mediate diverse biological processes through tetraspanin-enriched microdomains in the plasma membrane. However, how their cell-surface presentation is controlled remains unclear. To identify
Externí odkaz:
https://doaj.org/article/85cf40776e8e4f449d0d383fbf30fcde
Autor:
Sayan Chakraborty, Divyaleka Sampath, Melissa Ong Yu Lin, Matthew Bilton, Cheng-Kuang Huang, Mui Hoon Nai, Kizito Njah, Pierre-Alexis Goy, Cheng-Chun Wang, Ernesto Guccione, Chwee-Teck Lim, Wanjin Hong
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Replenishing key extracellular matrix (ECM) proteins facilitate wound healing through unclear mechanisms. Here the authors report that injury-triggered Agrin, an ECM proteoglycan, tunes a mechanocompetent niche by engaging MMP-12, thereby enforcing e
Externí odkaz:
https://doaj.org/article/66e7f31bc2564edc8b704e9a42602d0d
Autor:
Huiying Liu, Yuxia Zhou, Hantian Qiu, Ruijuan Zhuang, Yang Han, Xiaoqing Liu, Xi Qiu, Ziyan Wang, Liju Xu, Ran Tan, Wanjin Hong, Tuanlao Wang
Publikováno v:
Cell Death and Disease, Vol 12, Iss 4, Pp 1-15 (2021)
Abstract Rab proteins play crucial roles in membrane trafficking. Some Rab proteins are implicated in cancer development through regulating protein sorting or degradation. In this study, we found that the expression of Rab26 is suppressed in the aggr
Externí odkaz:
https://doaj.org/article/cf4f7a82476c496c8fb862fe1bdfa146