Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Wan-Pin Chang"'
Autor:
Timothy M. Griffin, Collin Kent, Susan Kovats, Florea Lupu, Joanna Hudson, Robert Silasi-Mansat, Rheal A. Towner, Wan Pin Chang, Erika Barboza
Publikováno v:
Arthritisrheumatology (Hoboken, N.J.). 69(6)
Objective To test the hypothesis that high-fat (HF) diet–induced obesity increases proinflammatory cytokine expression, macrophage infiltration, and M1 polarization in the infrapatellar fat pad (IFP) prior to knee cartilage degeneration. Methods We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5a87b4e6bbba87e5ba0f763f59fc0f9
https://pubmed.ncbi.nlm.nih.gov/28141918
https://pubmed.ncbi.nlm.nih.gov/28141918
Publikováno v:
Developmental & Comparative Immunology. 29:265-273
Beginning at hatching, male Cornell K strain single comb white leghorn chickens were fed a basal diet, with or without vitamin E (100 IU/kg) and/or selenium (Se, 0.2 ppm). After 3 weeks of treatment, animals fed either the Se-deficient or basal diet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7395c892263ce676c12172bcc0b36253
https://doi.org/10.1016/j.dci.2004.07.004
https://doi.org/10.1016/j.dci.2004.07.004
Publikováno v:
FEBS Letters. 524:183-187
Memapsin 2, or beta-secretase, is a membrane-anchored aspartic protease that initiates the cleavage of beta-amyloid precursor protein (APP) leading to the production of beta-amyloid peptide in the brain and the onset of Alzheimer's disease. Memapsin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c1c77424b2afb072d6538c17f3cd6bd
https://doi.org/10.1016/s0014-5793(02)03052-1
https://doi.org/10.1016/s0014-5793(02)03052-1
Autor:
Wan-Pin Chang, Charles V. Clevenger
Publikováno v:
Proceedings of the National Academy of Sciences. 93:5947-5952
Activation of prolactin (PRL)-dependent signaling occurs as the result of ligand-induced dimerization of receptor (PRLr). Although three PRLr isoforms (short, intermediate, and long) have been characterized and are variably coexpressed in PRL-respons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b727c08e760e408d1ac6ce20ffddbd79
https://doi.org/10.1073/pnas.93.12.5947
https://doi.org/10.1073/pnas.93.12.5947
Autor:
Deborah Downs, John R. Cirrito, Wan Pin Chang, Arun K. Ghosh, Jordan Tang, Xiangping Huang, Gerald Koelsch, David M. Holtzman
Alzheimer disease is intimately linked to an excess amount of amyloid-β (Aβ) in the brain. Thus, therapeutic inhibition of Aβ production is an attractive clinical approach to treat this disease. Here we provide the first direct experimental eviden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::315717bea6b55f6c9fa4870bd39d337d
https://europepmc.org/articles/PMC3023390/
https://europepmc.org/articles/PMC3023390/
Autor:
Wan-Pin Chang, Jordan Tang, Kar-Ming Fung, Xiangping Huang, Deborah Downs, Huining Da, Judith A. James
Publikováno v:
Alzheimer's & Dementia. 4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a11c593b103b9c56910ae9c01ce8f22b
https://doi.org/10.1016/j.jalz.2008.05.1400
https://doi.org/10.1016/j.jalz.2008.05.1400
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 21(12)
Memapsin 2 (beta-secretase, BACE1) is the protease that initiates cleavage of beta-amyloid precursor protein leading to the production of amyloid-beta (Abeta) and the onset of Alzheimer's disease (AD). Reducing Abeta by targeting memapsin 2 is a majo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11afcee337fb8da214449232c0c352a8
https://pubmed.ncbi.nlm.nih.gov/17494994
https://pubmed.ncbi.nlm.nih.gov/17494994
Publikováno v:
Alzheimer's & Dementia. 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e75e03576056ece3bdda24f32fb2a62b
https://doi.org/10.1016/j.jalz.2006.05.063
https://doi.org/10.1016/j.jalz.2006.05.063
Publikováno v:
Acta biochimica et biophysica Sinica. 36(12)
Memapsin 2 (beta-secretase) is the membrane-anchored aspartic protease that initiates the cleavage of beta-amyloid precursor protein (APP) leading to the production of amyloid-beta (Abeta), a major factor in the pathogenesis of Alzheimer's disease (A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b550394762efe25dc903ad50a8036b8
https://pubmed.ncbi.nlm.nih.gov/15592644
https://pubmed.ncbi.nlm.nih.gov/15592644
Autor:
Stephen Wong, Jordan Tang, Arun K. Ghosh, Geoffrey Bilcer, Thippeswamy Devasamudram, Gerald Koelsch, Wan-Pin Chang, Huining Da, Brian Gordon, Deborah Downs, Vajira Weerasena
Publikováno v:
Journal of neurochemistry. 89(6)
We have previously reported structure-based design of memapsin 2 (beta-secretase) inhibitors with high potency. Here we show that two such inhibitors covalently linked to a "carrier peptide" penetrated the plasma membrane in cultured cells and inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63088b9973d6629225c4cf0f0b9366ab
https://pubmed.ncbi.nlm.nih.gov/15189343
https://pubmed.ncbi.nlm.nih.gov/15189343