Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Wan-Hung Lee"'
Autor:
Shukkwan K. Chen, Zachary C.E. Hawley, Maria I. Zavodszky, Sam Hana, Daniel Ferretti, Branka Grubor, Michael Hawes, Shanqin Xu, Stefan Hamann, Galina Marsh, Patrick Cullen, Ravi Challa, Thomas M. Carlile, Hang Zhang, Wan-Hung Lee, Andrea Peralta, Pete Clarner, Cong Wei, Kathryn Koszka, Feng Gao, Shih-Ching Lo
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 34, Iss , Pp 102057- (2023)
Toxic gain-of-function mutations in superoxide dismutase 1 (SOD1) contribute to approximately 2%–3% of all amyotrophic lateral sclerosis (ALS) cases. Artificial microRNAs (amiRs) delivered by adeno-associated virus (AAV) have been proposed as a pot
Externí odkaz:
https://doaj.org/article/5ec0da9397c241b68917b1eaa7b24e0e
Autor:
Lara C. Lewis, Lingyan Chen, L. Shahul Hameed, Robert R. Kitchen, Cyrielle Maroteau, Shilpa R. Nagarajan, Jenny Norlin, Charlotte E. Daly, Iwona Szczerbinska, Sara Toftegaard Hjuler, Rahul Patel, Eilidh J. Livingstone, Tom N. Durrant, Elisabeth Wondimu, Soumik BasuRay, Anandhakumar Chandran, Wan-Hung Lee, Sile Hu, Barak Gilboa, Megan E. Grandi, Enrique M. Toledo, Abdullah H.A. Erikat, Leanne Hodson, William G. Haynes, Natalie W. Pursell, Ken Coppieters, Jan Fleckner, Joanna M.M. Howson, Birgitte Andersen, Maxwell A. Ruby
Publikováno v:
JHEP Reports, Vol 5, Iss 5, Pp 100693- (2023)
Background & Aims: Non-alcoholic fatty liver disease (NAFLD) has a prevalence of ∼25% worldwide, with significant public health consequences yet few effective treatments. Human genetics can help elucidate novel biology and identify targets for new
Externí odkaz:
https://doaj.org/article/dfadb6aa5c1e408c8dd0a8e68452c677
Autor:
Lawrence M. Carey, Tannia Gutierrez, Liting Deng, Wan-Hung Lee, Ken Mackie, Andrea G. Hohmann
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract The G-protein coupled receptor GPR55 has been postulated to serve as a novel cannabinoid receptor. A previous report indicated that GPR55 knockout mice fail to develop mechanical hyperalgesia, suggesting a pro-nociceptive role for GPR55 in t
Externí odkaz:
https://doaj.org/article/4b5b7f6227954b9f86d12bdebdc63a59
Autor:
Wan-Hung Lee1, Hohmann, Andrea G.1,2,3,4, Carey, Lawrence M.2,3, Zhili Xu3, Lai, Yvonne Y.3,5, Li-Li Li5, Courtney, Michael J.5
Publikováno v:
Molecular Pain. 9/18/2018, Vol. 14, p1-17. 17p.
Autor:
Aarti Chawla, Yvonne Lai, Andy Hudmon, Andrea G. Hohmann, Wan-Hung Lee, Li-Li Li, Michael J. Courtney
Publikováno v:
PAIN. 159(5):849-863
Elevated N-methyl-D-aspartate receptor (NMDAR) activity is linked to central sensitization and chronic pain. However, NMDAR antagonists display limited therapeutic potential due to their adverse side effects. Novel approaches targeting the NR2B-PSD95
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acbca7e25e9d5f9d5c491badfbb72557
https://doi.org/10.1097/j.pain.0000000000001152
https://doi.org/10.1097/j.pain.0000000000001152
Autor:
Tannia Gutierrez, Pushkar M. Kulkarni, Wan-Hung Lee, Lawrence M. Carey, Andrea G. Hohmann, Ganesh A. Thakur, Yvonne Lai
Publikováno v:
Neuroscience. 349:303-317
Excessive activation of NMDA receptor (NMDAR) signaling within the spinal dorsal horn contributes to central sensitization and the induction and maintenance of pathological pain states. However, direct antagonism of NMDARs produces undesirable side e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ecf830dcc4f7be60f86349b7be4e0e4
https://doi.org/10.1016/j.neuroscience.2017.02.055
https://doi.org/10.1016/j.neuroscience.2017.02.055
Autor:
Zhili Xu, Lawrence M. Carey, Yvonne Lai, Wan-Hung Lee, Li-Li Li, Andrea G. Hohmann, Michael J. Courtney
Publikováno v:
Molecular Pain.
Elevated N-methyl-D-aspartate receptor activity contributes to central sensitization. Our laboratories and others recently reported that disrupting protein-protein interactions downstream of N-methyl-D-aspartate receptors suppresses pain. Specificall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db29726aba45a7248f90ffd710765f96
https://doi.org/10.1177/1744806918801224
https://doi.org/10.1177/1744806918801224
Autor:
Zhili Xu, Ganesh A. Thakur, Nicole M. Ashpole, Andrea G. Hohmann, Andy Hudmon, Wan-Hung Lee, Pushkar M. Kulkarni, Yvonne Lai
Publikováno v:
Neuropharmacology. 97:464-475
Aberrant increases in NMDA receptor (NMDAR) signaling contributes to central nervous system sensitization and chronic pain by activating neuronal nitric oxide synthase (nNOS) and generating nitric oxide (NO). Because the scaffolding protein postsynap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3beedf5dd1a048c02c18f2848461dd1
https://doi.org/10.1016/j.neuropharm.2015.05.038
https://doi.org/10.1016/j.neuropharm.2015.05.038
Autor:
Ken Mackie, Liting Deng, Lawrence M. Carey, Tannia Gutierrez, Andrea G. Hohmann, Wan-Hung Lee
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
The G-protein coupled receptor GPR55 has been postulated to serve as a novel cannabinoid receptor. A previous report indicated that GPR55 knockout mice fail to develop mechanical hyperalgesia, suggesting a pro-nociceptive role for GPR55 in the contro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3c6f1f4f9760db4893a1ffb9b415c47
https://pubmed.ncbi.nlm.nih.gov/28428628
https://pubmed.ncbi.nlm.nih.gov/28428628
Publikováno v:
Pharmacological research. 114
Neuropathic pain impacts approximately 3-4.5% of the global population and remains an unresolved health problem. The management of neuropathic pain has two distinct goals-prevention of development and control of established neuropathic pain. We exami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05a1a1338bf105beaa7f8e61c6a50f0b
https://pubmed.ncbi.nlm.nih.gov/27773824
https://pubmed.ncbi.nlm.nih.gov/27773824