Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Wan Yun Ho"'
Autor:
Wan Yun Ho, Li-Ling Chak, Jin-Hui Hor, Fujia Liu, Sandra Diaz-Garcia, Jer-Cherng Chang, Emma Sanford, Maria J. Rodriguez, Durgadevi Alagappan, Su Min Lim, Yik-Lam Cho, Yuji Shimizu, Alfred Xuyang Sun, Sheue-Houy Tyan, Edward Koo, Seung Hyun Kim, John Ravits, Shi-Yan Ng, Katsutomo Okamura, Shuo-Chien Ling
Publikováno v:
iScience, Vol 26, Iss 11, Pp 108152- (2023)
Summary: MicroRNAs (miRNAs) modulate mRNA expression, and their deregulation contributes to various diseases including amyotrophic lateral sclerosis (ALS). As fused in sarcoma (FUS) is a causal gene for ALS and regulates biogenesis of miRNAs, we syst
Externí odkaz:
https://doaj.org/article/a1a36ec90cb447b39d91b7f4cf3e5ff6
Autor:
Wan Yun Ho, Ira Agrawal, Sheue-Houy Tyan, Emma Sanford, Wei-Tang Chang, Kenneth Lim, Jolynn Ong, Bernice Siu Yan Tan, Aung Aung Kywe Moe, Regina Yu, Peiyan Wong, Greg Tucker-Kellogg, Edward Koo, Kai-Hsiang Chuang, Shuo-Chien Ling
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-24 (2021)
Abstract Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) represent two ends of the same disease spectrum of adult-onset neurodegenerative diseases that affect the motor and cognitive functions, respectively. Multiple common gene
Externí odkaz:
https://doaj.org/article/a61ca5981b9148f9bbf509c59593da3a
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-7 (2020)
Abstract Hexanucleotide repeat expansion of C9ORF72 is the most common genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia. Synergies between loss of C9ORF72 functions and gain of toxicities from the repeat expansions contribut
Externí odkaz:
https://doaj.org/article/949834f4a46f490f87915c81d1734b86
Autor:
Kae-Jiun Chang, Ira Agrawal, Anna Vainshtein, Wan Yun Ho, Wendy Xin, Greg Tucker-Kellogg, Keiichiro Susuki, Elior Peles, Shuo-Chien Ling, Jonah R Chan
Publikováno v:
eLife, Vol 10 (2021)
TDP-43 is extensively studied in neurons in physiological and pathological contexts. However, emerging evidence indicates that glial cells are also reliant on TDP-43 function. We demonstrate that deletion of TDP-43 in Schwann cells results in a drama
Externí odkaz:
https://doaj.org/article/806e78a46128409587bd9290f6d060f7
Autor:
Shuo-Chien Ling, Somasish Ghosh Dastidar, Seiya Tokunaga, Wan Yun Ho, Kenneth Lim, Hristelina Ilieva, Philippe A Parone, Sheue-Houy Tyan, Tsemay M Tse, Jer-Cherng Chang, Oleksandr Platoshyn, Ngoc B Bui, Anh Bui, Anne Vetto, Shuying Sun, Melissa McAlonis-Downes, Joo Seok Han, Debbie Swing, Katannya Kapeli, Gene W Yeo, Lino Tessarollo, Martin Marsala, Christopher E Shaw, Greg Tucker-Kellogg, Albert R La Spada, Clotilde Lagier-Tourenne, Sandrine Da Cruz, Don W Cleveland
Publikováno v:
eLife, Vol 8 (2019)
Mutations in coding and non-coding regions of FUS cause amyotrophic lateral sclerosis (ALS). The latter mutations may exert toxicity by increasing FUS accumulation. We show here that broad expression within the nervous system of wild-type or either o
Externí odkaz:
https://doaj.org/article/04213ee8809d4946acefc96cd36ba9b2
Autor:
Katrianne Bethia Koh, Jerry Liu, Ira Agrawal, Jer-Cherng Chang, Emma Sanford, Greg Tucker-Kellogg, David H. Gutmann, Audrey Yi Tyan Peng, Shuo-Chien Ling, Jodie Hon Kiu Man, Ashley J. Pinter, Qi Xuan Cheryl Phua, Peiyan Wong, Wan Yun Ho, Yi-Chun Yen
Publikováno v:
Proc Natl Acad Sci U S A
Patients with amyotrophic lateral sclerosis (ALS) can have abnormal TDP-43 aggregates in the nucleus and cytosol of their surviving neurons and glia. Although accumulating evidence indicates that astroglial dysfunction contributes to motor neuron deg
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-7 (2020)
Acta Neuropathologica Communications
Acta Neuropathologica Communications
Hexanucleotide repeat expansion of C9ORF72 is the most common genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia. Synergies between loss of C9ORF72 functions and gain of toxicities from the repeat expansions contribute to C9OR
Autor:
Wan Yun Ho, Shuo-Chien Ling
Publikováno v:
Neuromethods ISBN: 9781071615881
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7552e0c8e49bffeccb039acf9eab193
https://doi.org/10.1007/978-1-0716-1589-8_9
https://doi.org/10.1007/978-1-0716-1589-8_9
Publikováno v:
The FEBS journalReferences. 289(24)
Amyotrophic lateral sclerosis (ALS), the most common adult-onset motor neuron disease, is characterized by the selective degeneration of motor neurons leading to paralysis and eventual death. Multiple pathogenic mechanisms, including systemic dysmeta
Autor:
Wan Yun Ho, Han-Ming Shen, Jer-Cherng Chang, Jun-Lin Guan, Huilin Zhou, Sheue-Houy Tyan, Yee Kit Tai, Song Chen, Jason Liang, Shuo-Chien Ling, Edward H. Koo
Publikováno v:
Autophagy
Mutations in C9orf72 leading to hexanucleotide expansions are the most common genetic causes for amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). A phenotype resembling ALS and FTD is seen in transgenic mice overexpressing the h