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Autor:
Wang, Zheng-Ran, Zhu, Li-Xia, Zhang, Xing-Lei, Li, Bo, Liu, Yu-Liang, Wan, Yong-Feng, Li, Qi, Wan, Yu, Yin, Hang, Shi, Ying
Publikováno v:
Chinese Journal of Chemical Physics (1674-0068); Apr2022, Vol. 35 Issue 2, p289-294, 6p
Publikováno v:
Drug Metabolism Letters
Background: Recently, it has been an increasing concern on the bioactivation and adverse re-actions associated with consumption of herbal and nature products. 7-Ethoxycoumarin is one of coumarin family compounds, but little information is available r
Publikováno v:
Drug Metabolism Letters. 6:73-93
The metabolic fate of green tea catechins [(-)-epicatechin ((-)-EC), (-)-epicatechin-3-gallate (ECG) (-)- epigallocatechin (EGC) and (-)-epigallocatechin-3-gallate (EGCG)] in cryopreserved human, monkey, dog, rat and mouse hepatocytes was studied. Me
Autor:
Wan Yong Feng
Publikováno v:
Current Drug Metabolism. 7:755-809
Green tea is one of the most popular beverages worldwide. Its major components include (-)-epicatechin ((-)-EC), (-)-epicatechin-3-gallate (ECG) (-)-epigallocatechin (EGC) and (-)-epigallocatechin-3-gallate (EGCG). It has demonstrated strong antioxid
Autor:
Wan Yong Feng
Publikováno v:
Current Drug Discovery Technologies. 1:295-312
Drug discovery in the pharmaceutical industry has shown great demands for screening absorption, distribution, metabolism, excretion (ADME) and pharmacokinetics (PK) in guiding the selection of lead candidate compounds. Determination of ADME/PK proper
Publikováno v:
International Journal of Mass Spectrometry. 222:117-134
A combination of mass spectrometry and ab initio calculations (MP2/6-31+G(d)//HF/6-31+G(d)) has been used to study the mechanism of C-terminal residue cleavage in gas phase peptide/alkali metal ion complexes. Although previous workers had suggested a
Publikováno v:
The Journal of Physical Chemistry A. 107:405-410
The lithium cation binding energies of 15 of the common amino acids were determined via the kinetic method in a quadrupole ion trap mass spectrometer. Values were obtained in two ways. First, a ladder of relative lithium cation binding energies was d
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 28:601-612
B201 (NSC 710295), [SUIM-(Darg-Arg-Pro-Hyp-Gly-Igl-Ser-Digl-Oic-Arg) 2 ], a third generation of bradykinin (BK) antagonist, has been found to possess high potency. We report the development of a highly sensitive electrospray LC–MS/MS assay method f
Publikováno v:
International Journal of Mass Spectrometry. :251-258
A combination of experimental and theoretical approaches have been used to probe the gas phase acidity and basicity of 1,3-dimethyluracil, 1-methyl-2-pyridone, and 1-methyl-4-pyridone. For the acidity measurements, bracketing experiments were complet