Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Wan Jun Lim"'
Autor:
Guanhua Zhu, Yu A. Guo, Danliang Ho, Polly Poon, Zhong Wee Poh, Pui Mun Wong, Anna Gan, Mei Mei Chang, Dimitrios Kleftogiannis, Yi Ting Lau, Brenda Tay, Wan Jun Lim, Clarinda Chua, Tira J. Tan, Si-Lin Koo, Dawn Q. Chong, Yoon Sim Yap, Iain Tan, Sarah Ng, Anders J. Skanderup
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Circulating tumour DNA (ctDNA) represents a non-invasive option to monitor cancer progression. Here, the authors perform deep sequencing of plasma cell-free DNA, and find that nucleosome-dependent cfDNA degradation at 6 specific regulatory regions is
Externí odkaz:
https://doaj.org/article/3c974350bb8a41b0a12aa9c3b0c56857
Autor:
Ignasius Joanito, Pratyaksha Wirapati, Nancy Zhao, Zahid Nawaz, Grace Yeo, Fiona Lee, Christine L. P. Eng, Dominique Camat Macalinao, Merve Kahraman, Harini Srinivasan, Vairavan Lakshmanan, Sara Verbandt, Petros Tsantoulis, Nicole Gunn, Prasanna Nori Venkatesh, Zhong Wee Poh, Rahul Nahar, Hsueh Ling Janice Oh, Jia Min Loo, Shumei Chia, Lih Feng Cheow, Elsie Cheruba, Michael Thomas Wong, Lindsay Kua, Clarinda Chua, Andy Nguyen, Justin Golovan, Anna Gan, Wan-Jun Lim, Yu Amanda Guo, Choon Kong Yap, Brenda Tay, Yourae Hong, Dawn Qingqing Chong, Aik-Yong Chok, Woong-Yang Park, Shuting Han, Mei Huan Chang, Isaac Seow-En, Cherylin Fu, Ronnie Mathew, Ee-Lin Toh, Lewis Z. Hong, Anders Jacobsen Skanderup, Ramanuj DasGupta, Chin-Ann Johnny Ong, Kiat Hon Lim, Emile K. W. Tan, Si-Lin Koo, Wei Qiang Leow, Sabine Tejpar, Shyam Prabhakar, Iain Beehuat Tan
Publikováno v:
Nature genetics. 54(7)
The consensus molecular subtype (CMS) classification of colorectal cancer is based on bulk transcriptomics. The underlying epithelial cell diversity remains unclear. We analyzed 373,058 single-cell transcriptomes from 63 patients, focusing on 49,155
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::feb4df11888eb6ef0ad590958d97b70b
https://pubmed.ncbi.nlm.nih.gov/35918514
https://pubmed.ncbi.nlm.nih.gov/35918514
Autor:
Yu A. Guo, Polly Poon, Zhong Wee Poh, Wan Jun Lim, Iain Tan, Brenda Tay, Tira Jing Ying Tan, Anders Jacobsen Skanderup, Pui Mun Wong, Dawn Qq Chong, Danliang Ho, Sarah Ng, Si-Lin Koo, Guanhua Zhu, Yoon Sim Yap, Yi Ting Lau, Dimitrios Kleftogiannis, Anna Gan, Mei Mei Chang, Clarinda Chua
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Profiling of circulating tumor DNA (ctDNA) may offer a non-invasive approach to monitor disease progression. Here, we develop a quantitative method, exploiting local tissue-specific cell-free DNA (cfDNA) degradation patterns, that accurately estimate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5182e4eaeb9734249fc56062229020e
https://doi.org/10.1038/s41467-021-22463-y
https://doi.org/10.1038/s41467-021-22463-y
Autor:
Florent Ginhoux, David Tai, Joe Yeong, Evan W. Newell, Jerry Kok Yen Chan, Chiew Yee Loh, Xiaomeng Zhang, Hong Kai Lee, Seng Gee Lim, Weiwei Zhai, Yang Cheng, Su Pin Choo, Etienne Becht, Chung Yip Chan, Wan Jun Lim, Brian K. P. Goh, Alexander Y. F. Chung, Jinmiao Chen, Bernett Lee, Jeremy Chase Crawford, Harsimran D. Singh, Jia Qi Lim, Bavani Gunasegaran, Pierce K. H. Chow, Charles-Antoine Dutertre
Publikováno v:
SSRN Electronic Journal.
In the context of hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC), despite a range of possibilities, the antigen specificities of tumor-infiltrating T cells and their relevance to control of is largely unknown. Using highly multiple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88f09db7d97d448e2c7eb4d227c28d2e
https://doi.org/10.2139/ssrn.3760654
https://doi.org/10.2139/ssrn.3760654
Autor:
Etienne Becht, Su Pin Choo, Charles-Antoine Dutertre, Seng Gee Lim, Jinmiao Chen, Chung Yip Chan, Florent Ginhoux, Bavani Gunasegaran, Yang Cheng, Brian K. P. Goh, Chiew Yee Chiew Yee Loh, Weiwei Zhai, Jeremy Chase Crawford, Jerry Kok Yen Chan, Pierce K. H. Chow, Joe Yeong, Hong Kai Lee, Alexander Y. F. Chung, H Singh, Evan W. Newell, David Tai, Bernett Lee, Jia Qi Lim, Wan Jun Lim, Xiao Meng Zhang
Publikováno v:
Immunity. 54(8)
Summary Hepatocellular carcinoma (HCC) often develops following chronic hepatitis B virus (HBV) infection and responds poorly to immune checkpoint blockade. Here, we examined the antigen specificities of HCC-infiltrating T cells and their relevance t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7af966953fb1c8daa76eb70538dc6152
https://pubmed.ncbi.nlm.nih.gov/34380061
https://pubmed.ncbi.nlm.nih.gov/34380061
Solitary fibrous tumour (SFT) is uncommonly found in the salivary glands and is a rare group of spindle-cell tumours. A review of literature revealed only 40 reported cases of SFT of major salivary glands over a 15-year period from 2004 to 2018. SFTs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a25b643d9739991839cb1c27a48ab13
https://europepmc.org/articles/PMC6556688/
https://europepmc.org/articles/PMC6556688/
Autor:
Claramae Shulyn Chia, Iain Beehuat Tan, Clarinda Chua, Wei Lin Goh, Johnny Ong, Danliang Ho, Eileen Poon, Woei Loon Tan, Mohamad Farid Bin Harunal Ras, Sarah B Ng, Nagavalli Somasundaram, Jiancheng Hong, Richard Quek, Anna Gan, Rebecca Lim, Melissa Ching Ching Teo, Wan Jun Lim, Grace Hwei Ching Tan, Jason Yongsheng Chan
PURPOSE: Gastrointestinal stromal tumors (GISTs) are characterized by primary mutations (PM) in KIT or PDGFRA genes. Under pharmacological pressure secondary mutations (SM) develop resulting in resistance to treatment. Our group developed a multiplex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6103ac5e119bfe51d010ce5c35fd3ed
https://doi.org/10.1101/481622
https://doi.org/10.1101/481622
Autor:
Joyce A. Tai, Wan Jun Lim, Joanna H. Tan, Igor Cima, Rob M. van Dam, Shyam Prabhakar, Wei Lin Goh, Min Hu, Axel M. Hillmer, Bing Lim, Mehran Rahmani, Min Hoe Chew, Jess Honganh Vo, Debarka Sengupta, Ciprian Iliescu, Say Li Kong, Daniel Lee, Paul Robson, Clarinda Chua, Min-Han Tan, Wai Min Phyo, Wei-Yen Lim, Rachel Ten, Poh Koon Koh, Nur-Afidah Mohamed Suhaimi, Jackie Y. Ying, Charlotte A. E. Hauser, Irina Alexander, Iain Beehuat Tan
Publikováno v:
Science Translational Medicine. 8
Clusters of tumor cells are often observed in the blood of cancer patients. These structures have been described as malignant entities for more than 50 years, although their comprehensive characterization is lacking. Contrary to current consensus, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b37f837a3415fad4441d421b6d57b44
https://doi.org/10.1126/scitranslmed.aad7369
https://doi.org/10.1126/scitranslmed.aad7369
Autor:
Pauline Ong, Hock Soo Ong, Shi Ya Mak, T. Fukawa, Clarinda Chua, Zhimei Li, Ng Shyh-Chang, Ying Swan Ho, Chao Nan Qian, Wan Jun Lim, Jiunn Herng Lai, Ruiqi Rachel Wang, Dan Huang, Hiro-omi Kanayama, Elwin Tan Jun-Hao, Bin Tean Teh, Shuwen Chen, Iain Beehuat Tan, Jason Chua Min-Wen, Ker-Kan Tan, Rosmin Elsa Mohan, Benjamin Chua Yan-Jiang
Publikováno v:
Chinese Journal of Cancer
Cachexia is a devastating muscle-wasting syndrome that occurs in patients who have chronic diseases. It is most commonly observed in individuals with advanced cancer1, 2, presenting in 80% of these patients, and it is one of the primary causes of mor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b168f95ebb48e1ed8183fca0fbd7bd0
https://hdl.handle.net/10356/81480
https://hdl.handle.net/10356/81480
Autor:
Hui Min Teo, Yunqin Lee, Wan Jun Lim, Eugene Shen Ann Yeo, Ke Xin Bok, Ee-Lin Toh, Subhra K. Biswas, Han Chong Toh, Jia Min Loo, Iain Beehuat Tan, Si-Lin Koo, Wah Siew Tan, Yi-Chin Toh, Fiona Yi Xin Lee, Who-Whong Wang, Si Qi Tan, Clarinda Chua, Ramanuj DasGupta, Lindsay Kua, Shumei Chia
Publikováno v:
Journal of Clinical Oncology. 36:e15531-e15531
e15531Background: Response to immune checkpoint inhibition is dismal in colorectal cancer (CRC). There are limited experimental models to evaluate immunotherapy in human CRC. We developed an ex viv...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e111fd4fdb4bc7b74b81084596cd915
https://doi.org/10.1200/jco.2018.36.15_suppl.e15531
https://doi.org/10.1200/jco.2018.36.15_suppl.e15531