Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Wan Chi Lin"'
Publikováno v:
Heliyon, Vol 9, Iss 5, Pp e16408- (2023)
Background: Chromosome analysis is laborious and time-consuming. Automated methods can significantly increase the efficiency of chromosome analysis. For the automated analysis of chromosome images, single and clustered chromosomes must be identified.
Externí odkaz:
https://doaj.org/article/81aad0d6a7874a13b124c2a4c0a5c4d6
Autor:
Lei Nie, Yongkun Wei, Fei Zhang, Yi-Hsin Hsu, Li-Chuan Chan, Weiya Xia, Baozhen Ke, Cihui Zhu, Rong Deng, Jun Tang, Jun Yao, Yu-Yi Chu, Xixi Zhao, Ye Han, Junwei Hou, Longfei Huo, How-Wen Ko, Wan-Chi Lin, Hirohito Yamaguchi, Jung-Mao Hsu, Yi Yang, Dean N. Pan, Jennifer L. Hsu, Celina G. Kleer, Nancy E. Davidson, Gabriel N. Hortobagyi, Mien-Chie Hung
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
EZH2 phosphorylation by CDK2 promotes progression of triple-negative breast cancer (TNBC). Here, the authors show that this signaling axis downregulates ERα, and thus combinatorial blockade of CDK2 and EZH2 sensitizes TNBC cells to tamoxifen.
Externí odkaz:
https://doaj.org/article/db070b7abc844972aa2cc8c48facb949
Autocrine IGF1 Signaling Mediates Pancreatic Tumor Cell Dormancy in the Absence of Oncogenic Drivers
Publikováno v:
Cell Reports, Vol 18, Iss 9, Pp 2243-2255 (2017)
Summary: Mutant KRAS and c-MYC are oncogenic drivers and rational therapeutic targets for the treatment of pancreatic cancer. Although tumor growth and homeostasis are largely dependent on these oncogenes, a few residual cancer cells are able to surv
Externí odkaz:
https://doaj.org/article/d8f5967056c4497faa2b68b74ce2b004
Autor:
Kay-Uwe Wagner, Hallgeir Rui, Jonathan R. Brody, Agnieszka K. Witkiewicz, Matthias Hebrok, John P. Morris, Michael A. Hollingsworth, Dominick J. DiMaio, Dean W. Felsher, Rene Opavsky, Surinder K. Batra, Aleata A. Triplett, Qian Zhang, Kazuhito Sakamoto, Chengbao Liu, Nirakar Rajbhandari, Wan-chi Lin
PDF file - 719K, Elevated c-MYC expression in human pancreatic cancer cell lines (S1); c-Myc is highly upregulated in a mouse model for pancreatic cancer (S2); Levels of c-Myc (exogenous and endogenous) in ductal and poorly differentiated pancreatic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14f0a8dbf2d7b30c8a6a8e5cffbfcb3a
https://doi.org/10.1158/0008-5472.22399502
https://doi.org/10.1158/0008-5472.22399502
Supplementary Figures 1-6 from Targeting Janus Kinase 2 in Her2/neu-Expressing Mammary Cancer: Implications for Cancer Prevention and Therapy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a75eafaf762ebd86bf299903ef460ad
https://doi.org/10.1158/0008-5472.22378983
https://doi.org/10.1158/0008-5472.22378983
Autor:
Kay-Uwe Wagner, Hallgeir Rui, Wan-chi Lin, Aleata A. Triplett, Chengbao Liu, Kazuhito Sakamoto, Qian Zhang
Cyclin D1 regulates cell proliferation and is a candidate molecular target for breast cancer therapy. This study addresses whether Cyclin D1 is indispensable for ErbB2-associated mammary tumor initiation and progression using a breast cancer model in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ed4f199529c549473f7ad7baba51ce4
https://doi.org/10.1158/0008-5472.c.6502878.v1
https://doi.org/10.1158/0008-5472.c.6502878.v1
Autor:
Kay-Uwe Wagner, Hallgeir Rui, Jonathan R. Brody, Agnieszka K. Witkiewicz, Matthias Hebrok, John P. Morris, Michael A. Hollingsworth, Dominick J. DiMaio, Dean W. Felsher, Rene Opavsky, Surinder K. Batra, Aleata A. Triplett, Qian Zhang, Kazuhito Sakamoto, Chengbao Liu, Nirakar Rajbhandari, Wan-chi Lin
PDF file - 40K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66f2e3c51b8c034ad74394382590c380
https://doi.org/10.1158/0008-5472.22399508.v1
https://doi.org/10.1158/0008-5472.22399508.v1
Autor:
Kay-Uwe Wagner, Hallgeir Rui, Jonathan R. Brody, Agnieszka K. Witkiewicz, Matthias Hebrok, John P. Morris, Michael A. Hollingsworth, Dominick J. DiMaio, Dean W. Felsher, Rene Opavsky, Surinder K. Batra, Aleata A. Triplett, Qian Zhang, Kazuhito Sakamoto, Chengbao Liu, Nirakar Rajbhandari, Wan-chi Lin
PDF file - 22K, Immunostaining of selected pancreatic cell lineage markers in ducal and poorly differentiated cancerous lesions of Pdx1-Cre/CAG-tTA/TetOMyc transgenic mice.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3baa5f7c0b4195ab37d25f44a682ebbf
https://doi.org/10.1158/0008-5472.22399496.v1
https://doi.org/10.1158/0008-5472.22399496.v1
Autor:
Kay-Uwe Wagner, Hallgeir Rui, Jonathan R. Brody, Agnieszka K. Witkiewicz, Matthias Hebrok, John P. Morris, Michael A. Hollingsworth, Dominick J. DiMaio, Dean W. Felsher, Rene Opavsky, Surinder K. Batra, Aleata A. Triplett, Qian Zhang, Kazuhito Sakamoto, Chengbao Liu, Nirakar Rajbhandari, Wan-chi Lin
PDF file - 28K, Supplemental Methods describing the genetic background of genetically engineered mice and methodology to quantify the expression of Myc in human pancreatic cancer.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ceeb41ee96d4cc9ca7fc1d748a2b16ab
https://doi.org/10.1158/0008-5472.22399499
https://doi.org/10.1158/0008-5472.22399499