Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Wan‐Lin Lo"'
Autor:
van Vlimmeren, Anne E., Voleti, Rashmi, Chartier, Cassandra A., Ziyuan Jiang, Karandur, Deepti, Humphries, Preston A., Wan-Lin Lo, Shah, Neel H.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 7/23/2024, Vol. 121 Issue 30, p1-11, 11p
Autor:
Wan-Lin Lo, Arthur Weiss
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Self- and non-self ligand discrimination is a core principle underlying T cell-mediated immunity. Mature αβ T cells can respond to a foreign peptide ligand presented by major histocompatibility complex molecules (pMHCs) on antigen presenting cells,
Externí odkaz:
https://doaj.org/article/730b13b6baa44b9e8b3d642694494773
Autor:
Joseph L. Ransdell, Edward Dranoff, Brandon Lau, Wan-Lin Lo, David L. Donermeyer, Paul M. Allen, Jeanne M. Nerbonne
Publikováno v:
Cell Reports, Vol 19, Iss 3, Pp 532-544 (2017)
Summary: The resurgent component of voltage-gated Na+ (Nav) currents, INaR, has been suggested to provide the depolarizing drive for high-frequency firing and to be generated by voltage-dependent Nav channel block (at depolarized potentials) and unbl
Externí odkaz:
https://doaj.org/article/e856e8bc6d5743638b7f92c3b58afa42
Publikováno v:
Immunological Reviews. 307:145-160
Establishing both central and peripheral tolerance requires the appropriate TCR signaling strength to discriminate self- from agonist-peptide bound to self MHC molecules. ZAP70, a cytoplasmic tyrosine kinase, directly interacts with the TCR complex a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbe7651fad90211103c7eebb2d5a790e
https://doi.org/10.1111/imr.13058
https://doi.org/10.1111/imr.13058
Autor:
Preston A. Humphries, Wan-Lin Lo
Publikováno v:
Nature Immunology. 23:1297-1299
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9bd9fba19758d43a50ff9e15bd51d6ca
https://doi.org/10.1038/s41590-022-01296-x
https://doi.org/10.1038/s41590-022-01296-x
Autor:
Jasmin Corso, Enas Hallumi, Arthur Weiss, Deborah Yablonski, Meirav Sela, Dvora Beach, Henning Urlaub, Wan-Lin Lo, Ilana Oz, Samuel Wittman, Rose Shalah, Amy Isenberg
Publikováno v:
J Immunol
The costimulatory receptor CD28 synergizes with the TCR to promote IL-2 production, cell survival, and proliferation; yet the obligatory interdependence of TCR and CD28 signaling is not well understood. Upon TCR stimulation, Gads, a Grb2-family adapt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e3ba0fb10892be4ff61e6d2d320bb85
https://doi.org/10.4049/jimmunol.2001053
https://doi.org/10.4049/jimmunol.2001053
Publikováno v:
Proc Natl Acad Sci U S A
T cells exhibit remarkable sensitivity and selectivity in detecting and responding to agonist peptides (p) bound to MHC molecules in a sea of self pMHC molecules. Despite much work, understanding of the underlying mechanisms of distinguishing such li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b431c8ddc090ad7ab1f6c8bb1f1c594
https://doi.org/10.1073/pnas.2008303117
https://doi.org/10.1073/pnas.2008303117
Publikováno v:
eLife, Vol 3 (2014)
Naive T cell precursor frequency determines the magnitude of immunodominance. While a broad T cell repertoire requires diverse positively selecting self-peptides, how a single positively selecting ligand influences naive T cell precursor frequency re
Externí odkaz:
https://doaj.org/article/f8ffb3723fd2403fbaae3306d0c9a9d9
Publikováno v:
Oncogene
The exploitation of T cell-based immunotherapies and immune checkpoint blockade for cancer treatment has dramatically shifted oncological treatment paradigms and broadened the horizons of cancer immunology. Dendritic cells have emerged as the critica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f0e245728d986b4434e0e81da0c2962
https://pubmed.ncbi.nlm.nih.gov/34290401
https://pubmed.ncbi.nlm.nih.gov/34290401
Autor:
Arthur Weiss, Enas Hallumi, Jasmin Corso, Wan-Lin Lo, Deborah Yablonski, Ilana Oz, Meirav Sela, Samuel Wittman, Rose Shalah, Amy Isenberg, Henning Urlaub, Dvora Beach
The costimulatory receptor, CD28, synergizes with the T cell antigen receptor (TCR) to promote IL-2 production, cell survival and proliferation. Despite their profound synergy, the obligatory interdependence of the signaling pathways initiated by the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9db4d843d6b8fca18e1f86beb0ec8fa4
https://doi.org/10.1101/2020.09.11.293316
https://doi.org/10.1101/2020.09.11.293316
