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Impact of gut permeability on estimation of oral bioavailability for chemicals in commerce and the environment.

Autor: Honda GS; U.S. Environmental Protection Agency, Office of Research and Development, Center for Computational Toxicology and Exposure, Research Triangle Park, NC, USA., Kenyon EM; U.S. Environmental Protection Agency, Office of Research and Development, Center for Computational Toxicology and Exposure, Research Triangle Park, NC, USA., Davidson-Fritz S; U.S. Environmental Protection Agency, Office of Research and Development, Center for Computational Toxicology and Exposure, Research Triangle Park, NC, USA., Dinallo R; Cyprotex, Watertown, MA, USA., El Masri H; U.S. Environmental Protection Agency, Office of Research and Development, Center for Computational Toxicology and Exposure, Research Triangle Park, NC, USA., Korol-Bexell E; U.S. Environmental Protection Agency, Office of Research and Development, Center for Computational Toxicology and Exposure, Research Triangle Park, NC, USA., Li L; Cyprotex, Watertown, MA, USA., Angus D; Cyprotex, Watertown, MA, USA., Pearce RG; U.S. Environmental Protection Agency, Office of Research and Development, Center for Computational Toxicology and Exposure, Research Triangle Park, NC, USA., Sayre RR; U.S. Environmental Protection Agency, Office of Research and Development, Center for Computational Toxicology and Exposure, Research Triangle Park, NC, USA., Strock C; Cyprotex, Watertown, MA, USA., Thomas RS; U.S. Environmental Protection Agency, Office of Research and Development, Center for Computational Toxicology and Exposure, Research Triangle Park, NC, USA., Wetmore BA; U.S. Environmental Protection Agency, Office of Research and Development, Center for Computational Toxicology and Exposure, Research Triangle Park, NC, USA., Wambaugh JF; U.S. Environmental Protection Agency, Office of Research and Development, Center for Computational Toxicology and Exposure, Research Triangle Park, NC, USA.

Publikováno v: ALTEX [ALTEX] 2024 Oct 19. Date of Electronic Publication: 2024 Oct 19.

A Comparison of In Vitro Points of Departure with Human Blood Levels for Per- and Polyfluoroalkyl Substances (PFAS).

Autor: Judson RS; US Environmental Protection Agency, Research Triangle Park, NC 27711, USA., Smith D; US Environmental Protection Agency, Research Triangle Park, NC 27711, USA., DeVito M; US Environmental Protection Agency, Research Triangle Park, NC 27711, USA., Wambaugh JF; US Environmental Protection Agency, Research Triangle Park, NC 27711, USA., Wetmore BA; US Environmental Protection Agency, Research Triangle Park, NC 27711, USA., Paul Friedman K; US Environmental Protection Agency, Research Triangle Park, NC 27711, USA., Patlewicz G; US Environmental Protection Agency, Research Triangle Park, NC 27711, USA., Thomas RS; US Environmental Protection Agency, Research Triangle Park, NC 27711, USA., Sayre RR; US Environmental Protection Agency, Research Triangle Park, NC 27711, USA., Olker JH; US Environmental Protection Agency, Research Triangle Park, NC 27711, USA., Degitz S; US Environmental Protection Agency, Research Triangle Park, NC 27711, USA., Padilla S; US Environmental Protection Agency, Research Triangle Park, NC 27711, USA., Harrill JA; US Environmental Protection Agency, Research Triangle Park, NC 27711, USA., Shafer T; US Environmental Protection Agency, Research Triangle Park, NC 27711, USA., Carstens KE; US Environmental Protection Agency, Research Triangle Park, NC 27711, USA.

Publikováno v: Toxics [Toxics] 2024 Apr 05; Vol. 12 (4). Date of Electronic Publication: 2024 Apr 05.

Trust your gut: Establishing confidence in gastrointestinal models - An overview of the state of the science and contexts of use.

Autor: Debad S; SJD Consulting LLC, Ijamsville, MD, USA., Allen D; Inotiv, Inc., RTP, NC, USA., Bandele O; Center for Food Safety and Applied Nutrition, College Park, MD, USA., Bishop C; Wake Forest Institute for Regenerative Medicine, Winston Salem, NC, USA., Blaylock M; Inotiv, Inc., RTP, NC, USA., Brown P; Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, USA., Bunger MK; Altis Biosystems, Inc. Research Triangle Park, NC, USA., Co JY; Complex in vitro Systems, Genentech Inc, South San Francisco, CA, USA., Crosby L; Center for Food Safety and Applied Nutrition, College Park, MD, USA., Daniel AB; Inotiv, Inc., RTP, NC, USA., Ferguson SS; Mechanistic Toxicology Branch, Division of Translational Toxicology, NIEHS, National Institutes of Health, Bethesda, MD, USA., Ford K; Office of Clinical Pharmacology, US Food and Drug Administration, Silver Spring, MD, USA., Gamboa da Costa G; FDA National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR, USA., Gilchrist KH; 4D Bio³ Center for Biotechnology, Uniformed Services University, Bethesda, MD, USA., Grogg MW; 711th Human Performance Wing, Air Force Research Laboratory, Wright-Patterson AFB, OH, USA., Gwinn M; U.S. Environmental Protection Agency, Office of Research and Development, RTP, NC, USA., Hartung T; Johns Hopkins University, Bloomberg School of Public Health and Whiting School of Engineering, Doerenkamp-Zbinden-Chair for Evidence-based Toxicology, Center for Alternatives to Animal Testing (CAAT), Baltimore, MD, USA.; University of Konstanz, CAAT-Europe, Konstanz, Germany., Hogan SP; Mary H. Weiser Food Allergy Center, Department of Pathology, Michigan Medicine, University of Michigan, Ann Arbor, MI, USA., Jeong YE; Division of Applied Regulatory Science, Office of Clinical Pharmacology, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, USA., Kass GE; European Food Safety Authority, Parma, Italy., Kenyon E; U.S. Environmental Protection Agency, Office of Research and Development, RTP, NC, USA., Kleinstreuer NC; NIEHS/NICEATM, RTP, NC, USA., Kujala V; Emulate Inc., Boston, MA, USA., Lundquist P; Department of Pharmacy, Uppsala University, Uppsala, Sweden., Matheson J; U.S. Consumer Product Safety Commission, Rockville, MD, USA., McCullough SD; Exposure and Protection, RTI International, Durham, NC, USA., Melton-Celsa A; Department of Microbiology and Immunology, Uniformed Services University, Bethesda, MD, USA., Musser S; Center for Food Safety and Applied Nutrition, College Park, MD, USA., Oh I; Toxicology Research Division, Ministry of Food and Drug Safety, National Institute of Food and Drug Safety Evaluation, Republic of Korea., Oyetade OB; Inotiv, Inc., RTP, NC, USA., Patil SU; Divisions of Allergy and Clinical Immunology, Departments of Medicine and Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Petersen EJ; Biosystems and Biomaterials Division, National Institute of Standards and Technology, Gaithersburg, MD, USA., Sadrieh N; Center for Food Safety and Applied Nutrition, College Park, MD, USA., Sayes CM; Department of Environmental Science, Baylor University, Waco, TX, USA., Scruggs BS; Altis Biosystems, Inc. Research Triangle Park, NC, USA., Tan YM; U.S. Environmental Protection Agency, Office of Pesticide Programs, Research Triangle Park, NC, USA., Thelin B; Altis Biosystems, Inc. Research Triangle Park, NC, USA., Nelson MT; 711th Human Performance Wing, Air Force Research Laboratory, Wright-Patterson AFB, OH, USA., Tarazona JV; Spanish National Environmental Health Centre, Instituto de Salud Carlos III. Madrid, Spain., Wambaugh JF; U.S. Environmental Protection Agency, Office of Research and Development, RTP, NC, USA., Yang JY; Toxicology Research Division, Ministry of Food and Drug Safety, National Institute of Food and Drug Safety Evaluation, Cheongju, Republic of Korea., Yu C; Toxicology Research Division, Ministry of Food and Drug Safety, National Institute of Food and Drug Safety Evaluation, Cheongju, Republic of Korea., Fitzpatrick S; Center for Food Safety and Applied Nutrition, College Park, MD, USA.

Publikováno v: ALTEX [ALTEX] 2024; Vol. 41 (3), pp. 402-424. Date of Electronic Publication: 2024 May 15.

Characterizing Chemical Exposure Trends from NHANES Urinary Biomonitoring Data.

Autor: Stanfield Z; Center for Computational Toxicology and Exposure, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, North Carolina, USA., Setzer RW; Center for Computational Toxicology and Exposure, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, North Carolina, USA., Hull V; Center for Computational Toxicology and Exposure, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, North Carolina, USA.; Oak Ridge Associated Universities, Oak Ridge, Tennessee, USA., Sayre RR; Center for Computational Toxicology and Exposure, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, North Carolina, USA.; Oak Ridge Associated Universities, Oak Ridge, Tennessee, USA., Isaacs KK; Center for Computational Toxicology and Exposure, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, North Carolina, USA., Wambaugh JF; Center for Computational Toxicology and Exposure, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, North Carolina, USA.

Publikováno v: Environmental health perspectives [Environ Health Perspect] 2024 Jan; Vol. 132 (1), pp. 17009. Date of Electronic Publication: 2024 Jan 29.