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Akademický článek

ONT sequencing identifies a high prevalence of crt sensitive, triple mutant dhfr and single mutant dhps parasites within an ANC population in Nigeria

Autor: Adebanjo Jonathan Adegbola, Leonard Ndwiga, Kevin Wamae, Victor Osoti, Oluseye Oladotun Bolaji, Philip Bejon, Lynette Isabella Ochola-Oyier

Publikováno v: Frontiers in Genetics, Vol 15 (2024)

BackgroundMalaria in pregnancy is a major public health issue, particularly among vulnerable populations in malaria-endemic sub-Saharan African countries. To mitigate its risks, WHO recommends sulphadoxine-pyrimethamine (SP) for chemoprevention and a

Externí odkaz: https://doaj.org/article/2bd130d4f277485d9741e051482a17ea

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Akademický článek

Factors associated with facility childbirth and skilled birth attendance in Migori County, Kenya and the effect of Lwala Community Alliance intervention: a cross-sectional assessment from the 2019 and 2021 Lwala household surveys

Autor: Christina Hope Lefebvre, Joseph R. Starnes, Aleksandra Jakubowski, Alyn Omondi, Janet Manyala, Jane Wamae, Ash Rogers, Sandra Mudhune, Vincent Okoth, Vincent Were, Julius Mbeya, Samantha V. Yap, Philip Omondi, Willys Ochieng, Tom Odhong, Carren Siele, Richard Wamai

Publikováno v: Frontiers in Global Women's Health, Vol 5 (2024)

BackgroundDespite evidence of the beneficial effects of skilled birth attendance (SBA) on maternal health and childbirth outcomes, there are disparities in access across counties in Kenya. These include Migori County which has historically recorded h

Externí odkaz: https://doaj.org/article/861f5923c4104501a8dd1fb62d95367c

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Akademický článek

Detection of P. malariae using a new rapid isothermal amplification lateral flow assay

Autor: Ashenafi Assefa, Kevin Wamae, Christopher M. Hennelly, Billy Ngasala, Meredith Muller, Albert Kalonji, Fernandine Phanzu, Clark H. Cunningham, Jessica T. Lin, Jonathan B. Parr

Publikováno v: Malaria Journal, Vol 23, Iss 1, Pp 1-7 (2024)

Abstract Background While Plasmodium falciparum and Plasmodium vivax cause the majority of malaria cases and deaths, infection by Plasmodium malariae and other Plasmodium species also causes morbidity and mortality. Current understanding of these inf

Externí odkaz: https://doaj.org/article/fd4c03140d8c4a7e99d53cb6e3e27944

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Akademický článek

Interpersonal violence against women and maternity care in Migori County, Kenya: evidence from a cross-sectional survey

Autor: Sophie K. Schellhammer, Joseph R. Starnes, Sandra Mudhune, Lou Goore, Lauren Marlar, Samuel Oyugi, Jane Wamae, Constance S. Shumba, Ash Rogers, Julius Mbeya, Beffy Vill, Angeline S. Otieno, Richard G. Wamai, Lawrence P. O. Were

Publikováno v: Frontiers in Global Women's Health, Vol 5 (2024)

BackgroundInterpersonal violence (IPV) is an issue of major public health concern, with 24% of Kenyan women reporting physical violence perpetrated by a current husband or partner. IPV has profound impacts on physical and mental health outcomes, part

Externí odkaz: https://doaj.org/article/b79527bc24e24957a431a9f90807dabe

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Akademický článek

Targeted amplicon deep sequencing of ama1 and mdr1 to track within-host P. falciparum diversity throughout treatment in a clinical drug trial [version 4; peer review: 2 approved, 2 approved with reservations]

Autor: Mainga Hamaluba, Juliana Wambua, Arjen M. Dondorp, Jennifer Musyoki, Caroline Ngetsa, Oksana Kharabora, Leonard Ndwiga, Zaydah de Laurent, Kevin Wamae, Kelvin Kimenyi, Gabriel Mwambingu, Peter Kalume, Philip Bejon, Jeffrey Bailey, Rob van der Pluijm, Lynette Ochola-Oyier, Jonathan Juliano, Victor Osoti

Publikováno v: Wellcome Open Research, Vol 7 (2024)

Introduction Antimalarial therapeutic efficacy studies are routinely conducted in malaria-endemic countries to assess the effectiveness of antimalarial treatment strategies. Targeted amplicon sequencing (AmpSeq) uniquely identifies and quantifies gen

Externí odkaz: https://doaj.org/article/54f1bc978ccb46b1ae6ec30ff6a0a2bd

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Akademický článek

SCHISTOACT: a protocol for an open-label, five-arm, non-inferiority, individually randomized controlled trial of the efficacy and safety of praziquantel plus artemisinin-based combinations in the treatment of Schistosoma mansoni infection

Autor: Charles O. Obonyo, Vincent O. Were, Peter Wamae, Erick M. O. Muok

Publikováno v: Trials, Vol 24, Iss 1, Pp 1-10 (2023)

Abstract Background Schistosomiasis control relies on praziquantel for preventive chemotherapy. Alternative drugs are needed for the treatment and control of schistosomiasis. Praziquantel is effective against adult schistosome worms but ineffective a

Externí odkaz: https://doaj.org/article/64d2ee218e2d4161b97566f104cb3bc0

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