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Multi-targeted anti-Alzheimer's agents: Synthesis, biological evaluation, and molecular modeling study of some pyrazolopyridine hybrids.

Autor: Waly OM; Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt; Pharmacy Center of Scientific Excellence, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt., El-Sayed SM; Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt; Pharmacy Center of Scientific Excellence, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt., Ghaly MA; Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt. Electronic address: mariamaghaly@mans.edu.eg., El-Subbagh HI; Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt; Pharmacy Center of Scientific Excellence, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt. Electronic address: subbagh@mans.edu.eg.

Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2023 Dec 15; Vol. 262, pp. 115880. Date of Electronic Publication: 2023 Oct 20.

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Akademický článek

Protective role of naftidrofuryl against methotrexate-induced testicular damage via the amelioration of the p53/miRNA-29a/CDC42 apoptotic pathway, inflammation, and oxidative stress.

Autor: Waly OM; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Tanta University, Tanta, Egypt. Electronic address: ola149959@pharm.tanta.edu.eg., El-Mahdy NA; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Tanta University, Tanta, Egypt., El-Shitany NAE; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Tanta University, Tanta, Egypt., Mohammedsaleh ZM; Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk, Saudi Arabia., El-Kadem AH; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Tanta University, Tanta, Egypt.

Publikováno v: Environmental toxicology and pharmacology [Environ Toxicol Pharmacol] 2023 Mar; Vol. 98, pp. 104067. Date of Electronic Publication: 2023 Jan 14.

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Akademický článek

Synthesis, biological evaluation, and molecular modeling simulations of new heterocyclic hybrids as multi-targeted anti-Alzheimer's agents.

Autor: Waly OM; Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt. Electronic address: omniawaly@mans.edu.eg., Saad KM; Department of Pharmacology, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt., El-Subbagh HI; Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt., Bayomi SM; Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt., Ghaly MA; Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt. Electronic address: mariamaghaly@mans.edu.eg.

Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2022 Mar 05; Vol. 231, pp. 114152. Date of Electronic Publication: 2022 Jan 22.

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Akademický článek

Investigating the Anti-inflammatory Effect of Quinoline Derivative: N1-(5-methyl-5H-indolo[2,3-b]quinolin-11-yl)benzene-1,4-diamine Hydrochloride Loaded Soluble Starch Nanoparticles Against Methotrexate-induced Inflammation in Experimental Model.

Autor: Medhat, Dalia¹ (AUTHOR) dalia_8383@hotmail.com, El-Bana, Mona A.¹ (AUTHOR), El-Tantawy El-Sayed, Ibrahim² (AUTHOR), Ahmed, Abdullah A. S.² (AUTHOR), El-Naggar, Mehrez E.³ (AUTHOR), Hussein, Jihan¹ (AUTHOR)

Publikováno v: Biological Procedures Online. 6/3/2024, Vol. 26 Issue 1, p1-18. 18p.

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Araucaria heterophylla oleogum resin essential oil is a novel aldose reductase and butyryl choline esterase enzymes inhibitor: in vitro and in silico evidence.

Autor: Soliman, Amal F.¹ (AUTHOR), Sabry, Mohamed A.² (AUTHOR), Abdelwahab, Gehad¹ (AUTHOR) Gehadabdelwahab@mans.edu.eg

Publikováno v: Scientific Reports. 7/15/2023, Vol. 13 Issue 1, p1-12. 12p.

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Artificial intelligence assisted identification of potential tau aggregation inhibitors: ligand- and structure-based virtual screening, in silico ADME, and molecular dynamics study.

Autor: Das, Bhanuranjan, Mathew, Alen T., Baidya, Anurag T. K., Devi, Bharti, Salmon, Rahul Rampa, Kumar, Rajnish

Publikováno v: Molecular Diversity; Aug2024, Vol. 28 Issue 4, p2013-2031, 19p

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Synthesis, Molecular Docking and Invitro Evaluation of Nipecotic Acid-Flavone Hybrids as Anti Alzheimer Agents. –A Multi Target Directed Ligand Approach.

Autor: Dhunmati, K.¹, Nalini, C. N.², Ramalakshmi, N.³, Niraimathi, V.⁴, Amuthalakshmi, S.¹

Publikováno v: Journal of Pharmaceutical Negative Results. 2022 Special Issue 7, Vol. 13, p229-238. 10p.

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Role of Nrf2/HO-1, PPAR-γ, and cytoglobin signals in the pathogenesis of methotrexate-induced testicular intoxication in rats and the protective effect of diacerein.

Autor: Abdel-Reheim MA; Department of Pharmaceutical Sciences, College of Pharmacy, Shaqra University, 11961, Shaqra, Saudi Arabia.; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, 62514, Egypt., Ali GF; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, 62514, Egypt., Hassanein EHM; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut, 71524, Egypt., Mohamed WR; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, 62514, Egypt. wafaa.mohamed@pharm.bsu.edu.eg.

Publikováno v: Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2024 Jun; Vol. 397 (6), pp. 4235-4246. Date of Electronic Publication: 2023 Dec 07.

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