Fabry disease Schwann cells release p11 to induce sensory neuron hyperactivity.

Autor: Waltz TB; Department of Cell Biology, Neurobiology & Anatomy., Chao D; Department of Anesthesiology; and., Prodoehl EK; Department of Cell Biology, Neurobiology & Anatomy., Enders JD; Department of Cell Biology, Neurobiology & Anatomy., Ehlers VL; Department of Cell Biology, Neurobiology & Anatomy., Dharanikota BS; Department of Cell Biology, Neurobiology & Anatomy., Dahms NM; Department of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin, USA., Isaeva E; Department of Cell Biology, Neurobiology & Anatomy., Hogan QH; Department of Anesthesiology; and., Pan B; Department of Anesthesiology; and., Stucky CL; Department of Cell Biology, Neurobiology & Anatomy.

Publikováno v: JCI insight [JCI Insight] 2024 Mar 07; Vol. 9 (8). Date of Electronic Publication: 2024 Mar 07.

Gut microbiota and metabolites drive chronic sickle cell disease pain.

Autor: Sadler KE; Department of Neuroscience, The University of Texas at Dallas; Richardson, TX.; Center for Advanced Pain Studies, The University of Texas at Dallas; Richardson, TX., Atkinson SN; Center for Microbiome Research, Medical College of Wisconsin; Milwaukee, WI.; Department of Microbiology and Immunology, Medical College of Wisconsin; Milwaukee, WI., Ehlers VL; Department of Cell Biology, Neurobiology & Anatomy, Medical College of Wisconsin; Milwaukee, WI., Waltz TB; Department of Cell Biology, Neurobiology & Anatomy, Medical College of Wisconsin; Milwaukee, WI., Hayward M; Center for Microbiome Research, Medical College of Wisconsin; Milwaukee, WI.; Department of Pediatrics, Division of Gastroenterology, Medical College of Wisconsin; Milwaukee, WI., Rodríguez García DM; Department of Cell Biology, Neurobiology & Anatomy, Medical College of Wisconsin; Milwaukee, WI., Salzman NH; Center for Microbiome Research, Medical College of Wisconsin; Milwaukee, WI.; Department of Microbiology and Immunology, Medical College of Wisconsin; Milwaukee, WI.; Department of Pediatrics, Division of Gastroenterology, Medical College of Wisconsin; Milwaukee, WI., Stucky CL; Department of Cell Biology, Neurobiology & Anatomy, Medical College of Wisconsin; Milwaukee, WI., Brandow AM; Department of Pediatrics, Section of Hematology/Oncology/Bone Marrow Transplantation, Medical College of Wisconsin; Milwaukee, WI.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Apr 28. Date of Electronic Publication: 2023 Apr 28.

Sensory-specific peripheral nerve pathology in a rat model of Fabry disease.

Autor: Waltz TB; Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI, USA., Burand AJ Jr; Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI, USA., Sadler KE; Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI, USA., Stucky CL; Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI, USA.

Publikováno v: Neurobiology of pain (Cambridge, Mass.) [Neurobiol Pain] 2021 Sep 02; Vol. 10, pp. 100074. Date of Electronic Publication: 2021 Sep 02 (Print Publication: 2021).

Nicotinamide Improves Aspects of Healthspan, but Not Lifespan, in Mice.

Autor: Mitchell SJ; Experimental Gerontology Section, Translational Gerontology Branch, National Institute on Aging, NIH, Baltimore, MD 21224, USA., Bernier M; Experimental Gerontology Section, Translational Gerontology Branch, National Institute on Aging, NIH, Baltimore, MD 21224, USA., Aon MA; Experimental Gerontology Section, Translational Gerontology Branch, National Institute on Aging, NIH, Baltimore, MD 21224, USA; Laboratory of Cardiovascular Science, National Institute on Aging, NIH, Baltimore, MD 21224, USA., Cortassa S; Laboratory of Cardiovascular Science, National Institute on Aging, NIH, Baltimore, MD 21224, USA., Kim EY; Experimental Gerontology Section, Translational Gerontology Branch, National Institute on Aging, NIH, Baltimore, MD 21224, USA; Functional Genomics Research Center, KRIBB, Daejeon 305-806, Republic of Korea., Fang EF; Laboratory of Molecular Gerontology, National Institute on Aging, NIH, Baltimore, MD 21224, USA., Palacios HH; Experimental Gerontology Section, Translational Gerontology Branch, National Institute on Aging, NIH, Baltimore, MD 21224, USA., Ali A; Experimental Gerontology Section, Translational Gerontology Branch, National Institute on Aging, NIH, Baltimore, MD 21224, USA., Navas-Enamorado I; Experimental Gerontology Section, Translational Gerontology Branch, National Institute on Aging, NIH, Baltimore, MD 21224, USA., Di Francesco A; Experimental Gerontology Section, Translational Gerontology Branch, National Institute on Aging, NIH, Baltimore, MD 21224, USA., Kaiser TA; Experimental Gerontology Section, Translational Gerontology Branch, National Institute on Aging, NIH, Baltimore, MD 21224, USA., Waltz TB; Laboratory of Molecular Gerontology, National Institute on Aging, NIH, Baltimore, MD 21224, USA., Zhang N; Department of Pharmacology, Weill Cornell Medicine, Cornell University, New York, NY 10065, USA., Ellis JL; Sirtris, a GSK Company, 200 Technology Square, Cambridge, MA 02139, USA., Elliott PJ; Sirtris, a GSK Company, 200 Technology Square, Cambridge, MA 02139, USA., Frederick DW; Department of Physiology, Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania, Philadelphia, PA 19104, USA., Bohr VA; Laboratory of Molecular Gerontology, National Institute on Aging, NIH, Baltimore, MD 21224, USA., Schmidt MS; Department of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA., Brenner C; Department of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA., Sinclair DA; Glenn Labs for the Biological Mechanisms of Aging, Harvard Medical School, Boston, MA 02115, USA., Sauve AA; Department of Pharmacology, Weill Cornell Medicine, Cornell University, New York, NY 10065, USA., Baur JA; Department of Physiology, Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania, Philadelphia, PA 19104, USA., de Cabo R; Experimental Gerontology Section, Translational Gerontology Branch, National Institute on Aging, NIH, Baltimore, MD 21224, USA. Electronic address: decabora@grc.nia.nih.gov.

Publikováno v: Cell metabolism [Cell Metab] 2018 Mar 06; Vol. 27 (3), pp. 667-676.e4.

Tomatidine enhances lifespan and healthspan in C. elegans through mitophagy induction via the SKN-1/Nrf2 pathway.

Autor: Fang EF; Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA., Waltz TB; Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA., Kassahun H; Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.; Institute of Clinical Medicine, University of Oslo and Akershus University Hospital, 1478 Lørenskog, Norway., Lu Q; Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA., Kerr JS; Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA., Morevati M; Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.; Danish Center for Healthy Aging, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark., Fivenson EM; Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA., Wollman BN; Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA., Marosi K; Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA., Wilson MA; Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA., Iser WB; Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA., Eckley DM; Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA., Zhang Y; Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA., Lehrmann E; Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA., Goldberg IG; Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA., Scheibye-Knudsen M; Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.; Danish Center for Healthy Aging, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark., Mattson MP; Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA., Nilsen H; Institute of Clinical Medicine, University of Oslo and Akershus University Hospital, 1478 Lørenskog, Norway., Bohr VA; Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.; Danish Center for Healthy Aging, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark., Becker KG; Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.

Publikováno v: Scientific reports [Sci Rep] 2017 Apr 11; Vol. 7, pp. 46208. Date of Electronic Publication: 2017 Apr 11.