Loss of zolpidem efficacy in the hippocampus of mice with the GABAAreceptor γ2 F77I point mutation

Autor: Elli Leppä, Peer Wulff, Waltraud Ogris, Marco Capogna, Peter Somogyi, H. Hoeger, Esa R. Korpi, Anni-Maija Linden, William Wisden, Werner Sieghart, A. Oberto, C. Halbsguth, Theofanis Karayannis, D. W. Cope, Francesco Ferraguti

Publikováno v: Cope, D W, Halbsguth, C, Karayannis, T, Wulff, P, Ferraguti, F, Hoeger, H, Leppä, E, Linden, A-M, Oberto, A, Ogris, W, Korpi, E R, Sieghart, W, Somogyi, P, Wisden, W & Capogna, M 2005, ' Loss of zolpidem efficacy in the hippocampus of mice with the GABAA receptor gamma2 F77I point mutation ', The European journal of neuroscience, vol. 21, no. 11, pp. 3002-16 . https://doi.org/10.1111/j.1460-9568.2005.04127.x
Europe PubMed Central

Zolpidem is a hypnotic benzodiazepine site agonist with some gamma-aminobutyric acid (GABA)(A) receptor subtype selectivity. Here, we have tested the effects of zolpidem on the hippocampus of gamma2 subunit (gamma2F77I) point mutant mice. Analysis of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d5a0e4e690a4883f85a630b50b1ff98
https://doi.org/10.1111/j.1460-9568.2005.04127.x

Abolition of zolpidem sensitivity in mice with a point mutation in the GABAA receptor γ2 subunit

Autor: A. Poeltl, Peter Somogyi, C. Halbsguth, M. I. Aller, Andrew N. J. McKenzie, Esa R. Korpi, Peer Wulff, Francesco Ferraguti, Helen E. Jolin, A. Oberto, Waltraud Ogris, Werner Sieghart, Marco Capogna, William Wisden, Erwin Sigel, D. W. Cope, H. Hoeger, A. Jones, Olga Vekovischeva, Saku T. Sinkkonen

Publikováno v: Cope, D W, Wulff, P, Oberto, A, Aller, M I, Capogna, M, Ferraguti, F, Halbsguth, C, Hoeger, H, Jolin, H E, Jones, A, McKenzie, A N J, Ogris, W, Poeltl, A, Sinkkonen, S T, Vekovischeva, O Y, Korpi, E R, Sieghart, W, Sigel, E, Somogyi, P & Wisden, W 2004, ' Abolition of zolpidem sensitivity in mice with a point mutation in the GABAA receptor gamma2 subunit ', Neuropharmacology, vol. 47, no. 1, pp. 17-34 . https://doi.org/10.1016/j.neuropharm.2004.03.007

Agonists of the allosteric benzodiazepine site of GABAA receptors bind at the interface of the alpha and gamma subunits. Here, we tested the in vivo contribution of the gamma2 subunit to the actions of zolpidem, an alpha1 subunit selective benzodiaze

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89ac0f98f84fc830d43a86bf89689b9a
https://doi.org/10.1016/j.neuropharm.2004.03.007

Affinity of various benzodiazepine site ligands in mice with a point mutation in the GABA(A) receptor gamma2 subunit

Autor: Birgit Hauer, Harald Höger, Margot Ernst, William Wisden, Angelika Pöltl, Werner Sieghart, Alessandra Oberto, Peer Wulff, Waltraud Ogris

Publikováno v: Biochemical pharmacology. 68(8)

The benzodiazepine binding site of GABA(A) receptors is located at the interface of the alpha and gamma subunits. Certain point mutations in these subunits have been demonstrated to dramatically reduce the affinity of benzodiazepine binding site liga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3560735223c3be4a524a318d556bad1
https://pubmed.ncbi.nlm.nih.gov/15451405