Precise DNA cleavage using CRISPR-SpRYgests.

Autor: Christie KA; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA.; Department of Pathology, Harvard Medical School, Boston, MA, USA., Guo JA; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA.; Biological and Biomedical Sciences Program, Harvard University, Boston, MA, USA., Silverstein RA; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA.; Biological and Biomedical Sciences Program, Harvard University, Boston, MA, USA., Doll RM; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA.; Molecular Biosciences/Cancer Biology Program, Heidelberg University and German Cancer Research Center (DKFZ), Heidelberg, Germany., Mabuchi M; New England Biolabs, Ipswich, MA, USA., Stutzman HE; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA., Lin J; Department of Pathology, Harvard Medical School, Boston, MA, USA.; Molecular Pathology Unit, Massachusetts General Hospital, Boston, MA, USA.; Center for Cancer Research, Massachusetts General Hospital Charlestown, Boston, MA, USA., Ma L; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA.; Department of Pathology, Harvard Medical School, Boston, MA, USA., Walton RT; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Pinello L; Department of Pathology, Harvard Medical School, Boston, MA, USA.; Molecular Pathology Unit, Massachusetts General Hospital, Boston, MA, USA.; Center for Cancer Research, Massachusetts General Hospital Charlestown, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Robb GB; New England Biolabs, Ipswich, MA, USA., Kleinstiver BP; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA. bkleinstiver@mgh.harvard.edu.; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA. bkleinstiver@mgh.harvard.edu.; Department of Pathology, Harvard Medical School, Boston, MA, USA. bkleinstiver@mgh.harvard.edu.

Publikováno v: Nature biotechnology [Nat Biotechnol] 2023 Mar; Vol. 41 (3), pp. 409-416. Date of Electronic Publication: 2022 Oct 06.

Whole-genome sequencing association analysis of quantitative red blood cell phenotypes: The NHLBI TOPMed program.

Autor: Hu Y, Stilp AM, McHugh CP, Rao S, Jain D, Zheng X, Lane J, Méric de Bellefon S, Raffield LM, Chen MH, Yanek LR, Wheeler M, Yao Y, Ren C, Broome J, Moon JY, de Vries PS, Hobbs BD, Sun Q, Surendran P, Brody JA, Blackwell TW, Choquet H, Ryan K, Duggirala R, Heard-Costa N, Wang Z, Chami N, Preuss MH, Min N, Ekunwe L, Lange LA, Cushman M, Faraday N, Curran JE, Almasy L, Kundu K, Smith AV, Gabriel S, Rotter JI, Fornage M, Lloyd-Jones DM, Vasan RS, Smith NL, North KE, Boerwinkle E, Becker LC, Lewis JP, Abecasis GR, Hou L, O'Connell JR, Morrison AC, Beaty TH, Kaplan R, Correa A, Blangero J, Jorgenson E, Psaty BM, Kooperberg C, Walton RT, Kleinstiver BP, Tang H, Loos RJF, Soranzo N, Butterworth AS, Nickerson D, Rich SS, Mitchell BD, Johnson AD, Auer PL, Li Y, Mathias RA, Lettre G, Pankratz N, Laurie CC, Laurie CA, Bauer DE, Conomos MP, Reiner AP

Publikováno v: American journal of human genetics [Am J Hum Genet] 2021 Jun 03; Vol. 108 (6), pp. 1165.

Publisher Correction: Engineered CRISPR-Cas12a variants with increased activities and improved targeting ranges for gene, epigenetic and base editing.

Autor: Kleinstiver BP; Molecular Pathology Unit, Massachusetts General Hospital, Charlestown, MA, USA. bkleinstiver@mgh.harvard.edu.; Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA, USA. bkleinstiver@mgh.harvard.edu.; Center for Computational and Integrative Biology, Massachusetts General Hospital, Charlestown, MA, USA. bkleinstiver@mgh.harvard.edu.; Department of Pathology, Harvard Medical School, Boston, MA, USA. bkleinstiver@mgh.harvard.edu.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA. bkleinstiver@mgh.harvard.edu., Sousa AA; Molecular Pathology Unit, Massachusetts General Hospital, Charlestown, MA, USA.; Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA, USA.; Center for Computational and Integrative Biology, Massachusetts General Hospital, Charlestown, MA, USA., Walton RT; Molecular Pathology Unit, Massachusetts General Hospital, Charlestown, MA, USA.; Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA, USA.; Center for Computational and Integrative Biology, Massachusetts General Hospital, Charlestown, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., Tak YE; Molecular Pathology Unit, Massachusetts General Hospital, Charlestown, MA, USA.; Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA, USA.; Center for Computational and Integrative Biology, Massachusetts General Hospital, Charlestown, MA, USA.; Department of Pathology, Harvard Medical School, Boston, MA, USA., Hsu JY; Molecular Pathology Unit, Massachusetts General Hospital, Charlestown, MA, USA.; Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA, USA.; Center for Computational and Integrative Biology, Massachusetts General Hospital, Charlestown, MA, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA., Clement K; Molecular Pathology Unit, Massachusetts General Hospital, Charlestown, MA, USA.; Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA, USA.; Department of Pathology, Harvard Medical School, Boston, MA, USA.; Cell Circuits and Epigenomics Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Welch MM; Molecular Pathology Unit, Massachusetts General Hospital, Charlestown, MA, USA.; Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA, USA.; Center for Computational and Integrative Biology, Massachusetts General Hospital, Charlestown, MA, USA., Horng JE; Molecular Pathology Unit, Massachusetts General Hospital, Charlestown, MA, USA.; Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA, USA.; Center for Computational and Integrative Biology, Massachusetts General Hospital, Charlestown, MA, USA., Malagon-Lopez J; Molecular Pathology Unit, Massachusetts General Hospital, Charlestown, MA, USA.; Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA, USA.; Center for Computational and Integrative Biology, Massachusetts General Hospital, Charlestown, MA, USA.; Department of Pathology, Harvard Medical School, Boston, MA, USA.; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Advance Artificial Intelligence Research Laboratory, WuXi NextCODE, Cambridge, MA, USA., Scarfò I; Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA, USA.; Cellular Immunotherapy Program, Cancer Center, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Maus MV; Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA, USA.; Cellular Immunotherapy Program, Cancer Center, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Pinello L; Molecular Pathology Unit, Massachusetts General Hospital, Charlestown, MA, USA.; Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA, USA.; Department of Pathology, Harvard Medical School, Boston, MA, USA.; Cell Circuits and Epigenomics Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Aryee MJ; Molecular Pathology Unit, Massachusetts General Hospital, Charlestown, MA, USA.; Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA, USA.; Department of Pathology, Harvard Medical School, Boston, MA, USA.; Cell Circuits and Epigenomics Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Joung JK; Molecular Pathology Unit, Massachusetts General Hospital, Charlestown, MA, USA. jjoung@mgh.harvard.edu.; Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA, USA. jjoung@mgh.harvard.edu.; Center for Computational and Integrative Biology, Massachusetts General Hospital, Charlestown, MA, USA. jjoung@mgh.harvard.edu.; Department of Pathology, Harvard Medical School, Boston, MA, USA. jjoung@mgh.harvard.edu.

Publikováno v: Nature biotechnology [Nat Biotechnol] 2020 Jul; Vol. 38 (7), pp. 901.

Identification of slit3 as a locus affecting nicotine preference in zebrafish and human smoking behaviour.

Autor: García-González J; School of Biological and Chemical Sciences, Queen Mary, University of London, London, United Kingdom., Brock AJ; School of Biological and Chemical Sciences, Queen Mary, University of London, London, United Kingdom., Parker MO; School of Pharmacy and Biomedical Science, University of Portsmouth, Portsmouth, United Kingdom., Riley RJ; School of Biological and Chemical Sciences, Queen Mary, University of London, London, United Kingdom., Joliffe D; Barts and The London School of Medicine and Dentistry, Blizard Institute, London, United Kingdom., Sudwarts A; School of Biological and Chemical Sciences, Queen Mary, University of London, London, United Kingdom., Teh MT; Centre for Immunobiology and Regenerative Medicine, Institute of Dentistry, Barts and The London School of Medicine and Dentistry, London, United Kingdom., Busch-Nentwich EM; Wellcome Trust Sanger Institute, Cambridge, United Kingdom.; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, United Kingdom., Stemple DL; Wellcome Trust Sanger Institute, Cambridge, United Kingdom., Martineau AR; Barts and The London School of Medicine and Dentistry, Blizard Institute, London, United Kingdom., Kaprio J; Institute for Molecular Medicine FIMM, HiLIFE, Helsinki, Finland.; Department of Public Health, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Palviainen T; Institute for Molecular Medicine FIMM, HiLIFE, Helsinki, Finland., Kuan V; Institute of Cardiovascular Science, University College London, London, United Kingdom., Walton RT; Barts and The London School of Medicine and Dentistry, Blizard Institute, London, United Kingdom., Brennan CH; School of Biological and Chemical Sciences, Queen Mary, University of London, London, United Kingdom.

Publikováno v: ELife [Elife] 2020 Mar 25; Vol. 9. Date of Electronic Publication: 2020 Mar 25.

高保真 CRISPR/Cas9 系统在家禽细胞中的编辑特性研究.

Autor: 焦丹荣^1,2 m15834071899@163.com, 马梦雪^2,3, 何柏水², 谢龙², 左二伟² zuoerwei@caas.cn

Publikováno v: Biotechnology Bulletin. Oct2024, Vol. 40 Issue 10, p191-197. 7p.