Spontaneous Development of Cutaneous Squamous Cell Carcinoma in Mice with Cell-specific Deletion of Inhibitor of κB Kinase 2

Autor: Kirkley, Kelly S, Walton, Kelly D, Duncan, Colleen, Tjalkens, Ronald B

The deletion of NFκB in epithelial tissues by using skin-specific promoters can cause both tumor formation and severe inflammatory dermatitis, indicating that this signaling pathway is important for the maintenance of immune homeostasis in epithelia

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https://europepmc.org/articles/PMC5621568/

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Spontaneous Development of Cutaneous Squamous Cell Carcinoma in Mice with Cell-specific Deletion of Inhibitor of κB Kinase 2.

Autor: Kirkley KS; Departments of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado., Walton KD; Departments of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado., Duncan C; Departments of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado., Tjalkens RB; Departments of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado;, Email: ron.tjalkens@colostate.edu.

Publikováno v: Comparative medicine [Comp Med] 2017 Oct 01; Vol. 67 (5), pp. 407-415.