Diversification of the VH3-53 immunoglobulin gene segment by somatic hypermutation results in neutralization of SARS-CoV-2 virus variants.

Autor: Bruhn M; Institute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Helmholtz Centre for Infection Research and the Hannover Medical School, Hannover, Germany., Obara M; Institute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Helmholtz Centre for Infection Research and the Hannover Medical School, Hannover, Germany., Salam A; Institute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Helmholtz Centre for Infection Research and the Hannover Medical School, Hannover, Germany., Costa B; Institute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Helmholtz Centre for Infection Research and the Hannover Medical School, Hannover, Germany., Ziegler A; Institute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Helmholtz Centre for Infection Research and the Hannover Medical School, Hannover, Germany., Waltl I; Institute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Helmholtz Centre for Infection Research and the Hannover Medical School, Hannover, Germany., Pavlou A; Institute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Helmholtz Centre for Infection Research and the Hannover Medical School, Hannover, Germany., Hoffmann M; Infection Biology Unit, German Primate Center, Göttingen, Germany.; Faculty of Biology, Georg-August-University Göttingen, Göttingen, Germany., Graalmann T; Department for Rheumatology and Immunology, Hannover Medical School, Hannover, Germany.; Junior Research Group for Translational Immunology, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Helmholtz Centre for Infection Research and the Hannover Medical School, Hannover, Germany.; Biomedical Research in End-Stage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover, Germany., Pöhlmann S; Infection Biology Unit, German Primate Center, Göttingen, Germany.; Faculty of Biology, Georg-August-University Göttingen, Göttingen, Germany., Schambach A; Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany.; Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.; German Center for Infection Research (DZIF), partner site Hannover-Braunschweig, Hannover, Germany., Kalinke U; Institute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Helmholtz Centre for Infection Research and the Hannover Medical School, Hannover, Germany.; German Center for Infection Research (DZIF), partner site Hannover-Braunschweig, Hannover, Germany.; Cluster of Excellence RESIST (EXC 2155), Hannover Medical School, Hannover, Germany.

Publikováno v: European journal of immunology [Eur J Immunol] 2024 Jul; Vol. 54 (7), pp. e2451056. Date of Electronic Publication: 2024 Apr 09.

Orchestration of antiviral responses within the infected central nervous system.

Autor: Pavlou A; Institute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Helmholtz Centre for Infection Research and the Hannover Medical School, 30625, Hannover, Germany., Mulenge F; Institute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Helmholtz Centre for Infection Research and the Hannover Medical School, 30625, Hannover, Germany., Gern OL; Institute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Helmholtz Centre for Infection Research and the Hannover Medical School, 30625, Hannover, Germany., Busker LM; Institute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Helmholtz Centre for Infection Research and the Hannover Medical School, 30625, Hannover, Germany.; Department of Pathology, University of Veterinary Medicine Hannover, Foundation, 30559, Hannover, Germany., Greimel E; Institute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Helmholtz Centre for Infection Research and the Hannover Medical School, 30625, Hannover, Germany., Waltl I; Institute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Helmholtz Centre for Infection Research and the Hannover Medical School, 30625, Hannover, Germany., Kalinke U; Institute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Helmholtz Centre for Infection Research and the Hannover Medical School, 30625, Hannover, Germany. ulrich.kalinke@twincore.de.; Cluster of Excellence RESIST (EXC 2155), Hannover Medical School, 30625, Hannover, Germany. ulrich.kalinke@twincore.de.

Publikováno v: Cellular & molecular immunology [Cell Mol Immunol] 2024 Sep; Vol. 21 (9), pp. 943-958. Date of Electronic Publication: 2024 Jul 12.

Innate immune response to SARS-CoV-2 infection contributes to neuronal damage in human iPSC-derived peripheral neurons.

Autor: Passos V; Hannover Medical School, Institute of Virology, Hannover, Germany., Henkel LM; Department of Neurology, Hannover Medical School, Hannover, Germany., Wang J; Hannover Medical School, Institute of Virology, Hannover, Germany., Zapatero-Belinchón FJ; University of Veterinary Medicine Hannover, Foundation, Hannover, Germany.; Cluster of Excellence-Resolving Infection Susceptibility (RESIST), Hannover Medical School, Hannover, Germany.; Department of Clinical Microbiology, Umeå University, Umeå, Sweden., Möller R; University of Veterinary Medicine Hannover, Foundation, Hannover, Germany., Sun G; Hannover Medical School, Institute of Virology, Hannover, Germany., Waltl I; Institute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, A Joint Venture between the Helmholtz Centre for Infection Research and the Hannover Medical School, Hannover, Germany., Schneider T; Hannover Medical School, Institute of Virology, Hannover, Germany., Wachs A; Hannover Medical School, Institute of Virology, Hannover, Germany., Ritter B; Hannover Medical School, Institute of Virology, Hannover, Germany., Kropp KA; Hannover Medical School, Institute of Virology, Hannover, Germany., Zhu S; Hannover Medical School, Institute of Virology, Hannover, Germany., Deleidi M; Center of Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany., Kalinke U; Cluster of Excellence-Resolving Infection Susceptibility (RESIST), Hannover Medical School, Hannover, Germany.; Institute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, A Joint Venture between the Helmholtz Centre for Infection Research and the Hannover Medical School, Hannover, Germany., Schulz TF; Hannover Medical School, Institute of Virology, Hannover, Germany.; Cluster of Excellence-Resolving Infection Susceptibility (RESIST), Hannover Medical School, Hannover, Germany., Höglinger G; Department of Neurology, Hannover Medical School, Hannover, Germany.; Cluster of Excellence-Resolving Infection Susceptibility (RESIST), Hannover Medical School, Hannover, Germany., Gerold G; University of Veterinary Medicine Hannover, Foundation, Hannover, Germany.; Cluster of Excellence-Resolving Infection Susceptibility (RESIST), Hannover Medical School, Hannover, Germany.; Department of Clinical Microbiology, Umeå University, Umeå, Sweden.; Wallenberg Centre for Molecular Medicine (WCMM), Umeå University, Umeå, Sweden., Wegner F; Department of Neurology, Hannover Medical School, Hannover, Germany., Viejo-Borbolla A; Hannover Medical School, Institute of Virology, Hannover, Germany.; Cluster of Excellence-Resolving Infection Susceptibility (RESIST), Hannover Medical School, Hannover, Germany.

Publikováno v: Journal of medical virology [J Med Virol] 2024 Feb; Vol. 96 (2), pp. e29455.

Memory B cells anticipate SARS-CoV-2 variants through somatic hypermutation.

Autor: Bruhn M; Institute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Helmholtz Centre for Infection Research and the Hannover Medical School, Hannover, Germany., Obara M; Institute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Helmholtz Centre for Infection Research and the Hannover Medical School, Hannover, Germany., Chiyyeadu A; Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany., Costa B; Institute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Helmholtz Centre for Infection Research and the Hannover Medical School, Hannover, Germany., Salam A; Institute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Helmholtz Centre for Infection Research and the Hannover Medical School, Hannover, Germany., Ziegler A; Institute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Helmholtz Centre for Infection Research and the Hannover Medical School, Hannover, Germany., Waltl I; Institute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Helmholtz Centre for Infection Research and the Hannover Medical School, Hannover, Germany., Pavlou A; Institute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Helmholtz Centre for Infection Research and the Hannover Medical School, Hannover, Germany., Bonifacius A; Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School, Hannover, Germany., Hoffmann M; Infection Biology Unit, German Primate Center, Göttingen, Germany; Faculty of Biology, Georg-August-University Göttingen, Göttingen, Germany., Graalmann T; Department for Rheumatology and Immunology, Hannover Medical School, Hannover, Germany; Junior Research Group for Translational Immunology, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Helmholtz Centre for Infection Research and the Hannover Medical School, Hannover, Germany; Biomedical Research in End-Stage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Germany., Pöhlmann S; Infection Biology Unit, German Primate Center, Göttingen, Germany; Faculty of Biology, Georg-August-University Göttingen, Göttingen, Germany., Eiz-Vesper B; Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School, Hannover, Germany., Schambach A; Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany; Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Kalinke U; Institute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Helmholtz Centre for Infection Research and the Hannover Medical School, Hannover, Germany; Cluster of Excellence RESIST (EXC 2155), Hannover Medical School, Hannover, Germany. Electronic address: Ulrich.Kalinke@twincore.de.

Publikováno v: The Journal of infection [J Infect] 2024 Jan; Vol. 88 (1), pp. 57-60. Date of Electronic Publication: 2023 Oct 31.

The attenuated Rift Valley fever virus strain clone 13 induces encephalitis in type 1 interferon competent mice

Autor: Michaely, L.M., Schuwerk, L., Allnoch, L., Schön, K., Waltl, I., Larsen, P.K., Pavlou, A., Prajeeth, C.K., Rimmelzwaan, G.F., Becker, S.C., Kalinke, U., Baumgärtner, W., Gerhauser, I.

Publikováno v: In Journal of Comparative Pathology May 2023 203:57-57