Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Walther Honscha"'
Autor:
Lydia Kuhnert, Robert Kuhnert, Menyhárt B. Sárosi, Cathleen Lakoma, Birte K. Scholz, Peter Lönnecke, Evamarie Hey‐Hawkins, Walther Honscha
Publikováno v:
Molecular Oncology, Vol 18, Iss 2, Pp 280-290 (2024)
Success of chemotherapy is often hampered by multidrug resistance. One mechanism for drug resistance is the elimination of anticancer drugs through drug transporters, such as breast cancer resistance protein (BCRP; also known as ABCG2), and causes a
Externí odkaz:
https://doaj.org/article/e96a44f6f69c429da99bfd278b0a0705
Autor:
Svetlana Paskas, Philipp Stockmann, Sanja Mijatović, Lydia Kuhnert, Walther Honscha, Evamarie Hey-Hawkins, Danijela Maksimović-Ivanić
Publikováno v:
Pharmaceuticals, Vol 16, Iss 11, p 1582 (2023)
The ABCG2 transporter protein, as part of several known mechanisms involved in multidrug resistance, has the ability to transport a broad spectrum of substrates out of the cell and is, therefore, considered as a potential target to improve cancer the
Externí odkaz:
https://doaj.org/article/f44fc984384e4ea0837672e47433a89e
Autor:
Philipp Stockmann, Lydia Kuhnert, Wencke Leinung, Cathleen Lakoma, Birte Scholz, Svetlana Paskas, Sanja Mijatović, Danijela Maksimović-Ivanić, Walther Honscha, Evamarie Hey-Hawkins
Publikováno v:
Pharmaceutics, Vol 15, Iss 1, p 241 (2023)
The ineffectiveness and failing of chemotherapeutic treatments are often associated with multidrug resistance (MDR). MDR is primarily linked to the overexpression of ATP-binding cassette (ABC) transporter proteins in cancer cells. ABCG2 (ATP-binding
Externí odkaz:
https://doaj.org/article/bf54c4b824f345338539badeb1131370
Autor:
Uwe Seibt, Peter Klötzer, Fanny Rachidi, Uwe Truyen, Stephanie Speck, Alexander Starke, Jil Waade, Walther Honscha
Publikováno v:
PLoS ONE, Vol 17, Iss 12, p e0278267 (2022)
Surveillance of antimicrobial administration in livestock production is an important factor in global policies to reduce spreading of antimicrobial resistance. In recent years, many studies have been carried out concerning the usage of antimicrobials
Externí odkaz:
https://doaj.org/article/7f4d0f81f56f489d81bfc5a4c40b6543
Autor:
Jil Waade, Uwe Seibt, Walther Honscha, Fanny Rachidi, Alexander Starke, Stephanie Speck, Uwe Truyen
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0248291 (2021)
We studied the prevalence of extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae in dairy calves as part of a routine health check protocol. In addition, data regarding antimicrobial use (AMU), farm hygiene, and farm management were
Externí odkaz:
https://doaj.org/article/a080aa3eb7bb45b89458b46083f0f64d
Publikováno v:
PLoS ONE, Vol 15, Iss 8, p e0237163 (2020)
In bovine mammary glands, the ABCG2 transporter actively secretes xenobiotics into dairy milk. This can have significant implications when cattle are exposed to pesticide residues in feed. Recent studies indicate that the fungicide prochloraz activat
Externí odkaz:
https://doaj.org/article/e609f6a8c8d3436b8440c07e29cd08dc
Autor:
Lisa van Rennings, Christiane von Münchhausen, Henry Ottilie, Maria Hartmann, Roswitha Merle, Walther Honscha, Annemarie Käsbohrer, Lothar Kreienbrock
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0119114 (2015)
To be able to analyze the relationship between the level of resistance and the use of antimicrobials, it is necessary to collect detailed data on antimicrobial usage. For this reason, data on antimicrobial use on 495 pig farms from entire Germany wer
Externí odkaz:
https://doaj.org/article/938bba668ee946fd958a563214508283
Autor:
Lydia Kuhnert, Svetlana Paskas, Dijana Drača, Robert Kuhnert, Sanja Mijatović, Evamarie Hey-Hawkins, Danijelа Maksimović-Ivanić, Menyhárt B. Sárosi, Dieter Steinhilber, Walther Honscha, Sven George, Bettina Hofmann
Publikováno v:
ChemMedChem. 17
12-Lipoxygenase is crucial for tumour angiogenesis. 5,6,7-Trihydroxy-2-phenyl-4 H -1-benzopyran-4-one (baicalein) is a suitable inhibitor for this enzyme but is rapidly metabolised in vivo . Thus, an improvement of the metabolic stability is necessar
Publikováno v:
Cytotechnology. 71:231-244
The knowledge of drug metabolising enzymes (DMEs) in cattle is rather limited. The capability of the bovine foetal hepatocyte-derived cell line BFH12 to serve as model for biotransformation was evaluated. Gene expression analysis of DMEs was performe
Autor:
Jil Waade, Uwe Seibt, Walther Honscha, Fanny Rachidi, Alexander Starke, Stephanie Speck, Uwe Truyen
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 3, p e0248291 (2021)
PLoS ONE, Vol 16, Iss 3, p e0248291 (2021)
We studied the prevalence of extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae in dairy calves as part of a routine health check protocol. In addition, data regarding antimicrobial use (AMU), farm hygiene, and farm management were