Global gene expression changes of in vitro stimulated human transformed germinal centre B cells as surrogate for oncogenic pathway activation in individual aggressive B cell lymphomas

Autor: Schrader Alexandra, Meyer Katharina, von Bonin Frederike, Vockerodt Martina, Walther Neele, Hand Elisabeth, Ulrich Antje, Matulewicz Kamila, Lenze Dido, Hummel Michael, Kieser Arnd, Engelke Michael, Trümper Lorenz, Kube Dieter

Publikováno v: Cell Communication and Signaling, Vol 10, Iss 1, p 43 (2012)

Abstract Background Aggressive Non-Hodgkin lymphomas (NHL) are a group of lymphomas derived from germinal centre B cells which display a heterogeneous pattern of oncogenic pathway activation. We postulate that specific immune response associated sign

Externí odkaz: https://doaj.org/article/e1887424bb374dd7a8e4217c260dd2b9

The MICA-129 dimorphism affects NKG2D signaling and outcome of hematopoietic stem cell transplantation

Autor: Isernhagen, Antje, Malzahn, Dörthe, Viktorova, Elena, Elsner, Leslie, Monecke, Sebastian, von Bonin, Frederike, Kilisch, Markus, Wermuth, Janne Marieke, Walther, Neele, Balavarca, Yesilda, Stahl-Hennig, Christiane, Engelke, Michael, Walter, Lutz, Bickeböller, Heike, Kube, Dieter, Wulf, Gerald, Dressel, Ralf

Publikováno v: EMBO Molecular Medicine

The MHC class I chain-related molecule A (MICA) is a highly polymorphic ligand for the activating natural killer (NK)-cell receptor NKG2D. A single nucleotide polymorphism causes a valine to methionine exchange at position 129. Presence of a MICA-129

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::27bad96c83bf0d443d3701370512746a
http://resolver.sub.uni-goettingen.de/purl?gs-1/12462

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The MICA-129 dimorphism affects NKG2D signaling and outcome of hematopoietic stem cell transplantation.

Autor: Isernhagen A; Institute of Cellular and Molecular Immunology, University Medical Center Göttingen, Göttingen, Germany., Malzahn D; Institute of Genetic Epidemiology, University Medical Center Göttingen, Göttingen, Germany., Viktorova E; Institute of Genetic Epidemiology, University Medical Center Göttingen, Göttingen, Germany., Elsner L; Institute of Cellular and Molecular Immunology, University Medical Center Göttingen, Göttingen, Germany., Monecke S; Institute of Cellular and Molecular Immunology, University Medical Center Göttingen, Göttingen, Germany., von Bonin F; Department of Hematology and Medical Oncology, University Medical Center Göttingen, Göttingen, Germany., Kilisch M; Institute of Molecular Biology, University Medical Center Göttingen, Göttingen, Germany., Wermuth JM; Department of Hematology and Medical Oncology, University Medical Center Göttingen, Göttingen, Germany., Walther N; Department of Hematology and Medical Oncology, University Medical Center Göttingen, Göttingen, Germany., Balavarca Y; Institute of Genetic Epidemiology, University Medical Center Göttingen, Göttingen, Germany., Stahl-Hennig C; Unit of Infection Models, German Primate Center, Göttingen, Germany., Engelke M; Institute of Cellular and Molecular Immunology, University Medical Center Göttingen, Göttingen, Germany., Walter L; Primate Genetics Laboratory, German Primate Center, Göttingen, Germany., Bickeböller H; Institute of Genetic Epidemiology, University Medical Center Göttingen, Göttingen, Germany., Kube D; Department of Hematology and Medical Oncology, University Medical Center Göttingen, Göttingen, Germany., Wulf G; Department of Hematology and Medical Oncology, University Medical Center Göttingen, Göttingen, Germany., Dressel R; Institute of Cellular and Molecular Immunology, University Medical Center Göttingen, Göttingen, Germany rdresse@gwdg.de.

Publikováno v: EMBO molecular medicine [EMBO Mol Med] 2015 Nov; Vol. 7 (11), pp. 1480-502.