Enhanced Survival of High-Risk Medulloblastoma-Bearing Mice after Multimodal Treatment with Radiotherapy, Decitabine, and Abacavir

Autor: Gringmuth, Marieke, Walther, Jenny, Greiser, Sebastian, Touissant, Magali, Schwalm, Benjamin, Kool, Marcel, Kortmann, Rolf-Dieter, Glasow, Annegret, Patties, Ina

Children with high-risk SHH/TP53-mut and Group 3 medulloblastoma (MB) have a 5-year overall survival of only 40%. Innovative approaches to enhance survival while preventing adverse effects are urgently needed. We investigated an innovative therapy ap

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Enhanced Survival of High-Risk Medulloblastoma-Bearing Mice after Multimodal Treatment with Radiotherapy, Decitabine, and Abacavir.

Autor: Gringmuth M; Department of Radiation Oncology, University of Leipzig, Stephanstraße 9a, 04103 Leipzig, Germany., Walther J; Fraunhofer Center for Microelectronic and Optical Systems for Biomedicine, Herman-Hollerith-Straße 3, 99099 Erfurt, Germany.; Fraunhofer Institute for Cell Therapy and Immunology, Perlickstraße 1, 04103 Leipzig, Germany., Greiser S; Fraunhofer Center for Microelectronic and Optical Systems for Biomedicine, Herman-Hollerith-Straße 3, 99099 Erfurt, Germany.; Fraunhofer Institute for Cell Therapy and Immunology, Perlickstraße 1, 04103 Leipzig, Germany., Toussaint M; Department of Neuroradiopharmaceuticals, Institute of Radiopharmaceutical Cancer Research Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Research Site Leipzig, Permoserstraße 15, 04318 Leipzig, Germany., Schwalm B; Hopp Children's Cancer Center (KiTZ), Im Neuenheimer Feld 430, 69120 Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Research Consortium (DKTK), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany., Kool M; Hopp Children's Cancer Center (KiTZ), Im Neuenheimer Feld 430, 69120 Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Research Consortium (DKTK), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.; Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, The Netherlands., Kortmann RD; Department of Radiation Oncology, University of Leipzig, Stephanstraße 9a, 04103 Leipzig, Germany., Glasow A; Department of Radiation Oncology, University of Leipzig, Stephanstraße 9a, 04103 Leipzig, Germany., Patties I; Department of Radiation Oncology, University of Leipzig, Stephanstraße 9a, 04103 Leipzig, Germany.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2022 Mar 30; Vol. 23 (7). Date of Electronic Publication: 2022 Mar 30.