Výsledky vyhledávání - "Walter van Rotterdam"

Cbl and Itch binding sites in ERBB4 CYT-1 and CYT-2 mediate K48- and K63-polyubiquitination, respectively

Autor: Walter van Rotterdam, Inez M.J. Meijer, Jeroen E.M. van Leeuwen, Everardus J.J. van Zoelen

Publikováno v: Cellular Signalling, 25, 2, pp. 470-478
Cellular Signalling, 25, 470-478

ERBB receptors have an important function in mammalian development and normal physiology, but overexpression and poor downregulation of ERBB receptors have been associated with malignant growth. Ligand-induced ERBB receptor signaling is terminated by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6557be12b8659969e41d2aabe18b4f89
https://hdl.handle.net/2066/103221

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Recycling of EGFR and ErbB2 is associated with impaired Hrs tyrosine phosphorylation and decreased deubiquitination by AMSH

Autor: Jeroen E.M. van Leeuwen, Inez M.J. Meijer, Everardus J.J. van Zoelen, Walter van Rotterdam

Publikováno v: Cellular Signalling, 24, 1981-1988
Cellular Signalling, 24, pp. 1981-1988

ErbB receptors play an important role in normal cellular growth, differentiation and development, but overexpression or poor downregulation can result in enhanced signaling and cancerous growth. ErbB signaling is terminated by clathrin-dependent rece

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c279172898c720d557c05eff226258bc
https://hdl.handle.net/2066/103684

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Role of the C-terminal linear region of EGF-like growth factors in ErbB specificity

Autor: Walter van Rotterdam, Jeroen E.M. van Leeuwen, Hanka Venselaar, Sebastian P. van der Woning, Everardus J.J. van Zoelen, Saskia Jacobs-Oomen

Publikováno v: Growth Factors, 27, 3, pp. 163-172
Growth Factors, 27, 3, pp. 163-72
Growth Factors, 27, 163-72
Growth Factors, 27, 163-172

Contains fulltext : 75950.pdf (Publisher’s version ) (Closed access) The epidermal growth factor (EGF)-like growth factors bind their ErbB receptors in a highly selective manner. Recently, we have shown that the sequence YYDLL in the C-terminal lin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fd448e5212b344b04ce511486ce3242
https://doi.org/10.1080/08977190902891010

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Negative constraints underlie the ErbB specificity of epidermal growth factor-like ligands

Autor: Sebastian P. van der Woning, Gert Vriend, Sander B. Nabuurs, Hanka Venselaar, Walter van Rotterdam, Everardus J.J. van Zoelen, Saskia Jacobs-Oomen, Catelijne Stortelers, Miriam Wingens

Publikováno v: Journal of Biological Chemistry, 281, 52, pp. 40033-40
Journal of Biological Chemistry, 281, 40033-40

Contains fulltext : 35633.pdf (Publisher’s version ) (Open Access) Epidermal growth factor (EGF)-like growth factors bind their ErbB receptors in a highly selective manner, but the molecular basis for this specificity is poorly understood. We have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e952a37a93b2e22860e605bfca45b049
https://doi.org/10.1074/jbc.m603168200

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Superagonistic Activation of ErbB-1 by EGF-related Growth Factors with Enhanced Association and Dissociation Rate Constants

Autor: Maureen D. O'connor-Mccourt, Walter van Rotterdam, Marianne J.H. van Vugt, Everardus J.J. van Zoelen, Anne E.G. Lenferink, Suzanne Grothe, Monique L.M. van de Poll

Publikováno v: Journal of Biological Chemistry, 275, 26748-26753
Journal of Biological Chemistry, 275, pp. 26748-26753

Epidermal growth factor (EGF) and transforming growth factor-alpha (TGFalpha) are mitogenic hormones that exert their activity primarily by binding to the EGF receptor, also known as ErbB-1. We have recently characterized a set of EGF/TGFalpha chimer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8bd052c54ab7064357cf180ba5b5eb9
https://doi.org/10.1016/s0021-9258(19)61439-0

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Epigenetics: DNA demethylation promotes skeletal myotube maturation

Autor: Roselinde I. van Ravestein-van Os, Everardus J.J. van Zoelen, Malin K.B. Jonsson, Eugene P. van Someren, Wim J.J.M. Scheenen, Ana M. Sotoca, Dirk L. Ypey, Marlinda Hupkes, Walter van Rotterdam, S. Bauerschmidt, Toon A.B. van Veen, Koen J. Dechering, Ester Piek, Marcel A.G. van der Heyden

Publikováno v: The Faseb Journal, 25, 11, pp. 3861-3872
FASEB Journal, 11, 25, 3861-3872
FASEB Journal, 25(11), 3861-3872
The Faseb Journal, 25, 3861-3872

Mesenchymal progenitor cells can be differentiated in vitro into myotubes that exhibit many characteristic features of primary mammalian skeletal muscle fibers. However, in general, they do not show the functional excitation-contraction coupling or t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a52ae9e7e7dbb0172eecb40593b8ccca
https://hdl.handle.net/2066/91778

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Ligand depletion negatively controls the mitogenic activity of epidermal growth factor

Autor: Monique L.M. van de Poll, Saskia Jacobs-Oomen, Mireille M. Gadellaa, Everardus J.J. van Zoelen, Walter van Rotterdam

Publikováno v: Experimental Cell Research, 304, 630-41
Experimental Cell Research, 304, 2, pp. 630-41

Contains fulltext : 32682.pdf (Publisher’s version ) (Closed access) EGF activates the ErbB1 receptor, but there appears only a limited correlation between its receptor binding affinity and mitogenic activity. This is indicated by our present obser

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2350b5c082c0ffb0fa785f39bd1cc9c
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15748906

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Non-linear antigenic regions in epidermal growth factor (EGF) and transforming growth factor alpha (TGFalpha) studied by EGF-TGFalpha chimaeras

Autor: Mireille M. Gadellaa, Everardus J.J. van Zoelen, Walter van Rotterdam, Monique L.M. van de Poll, Catelijne Stortelers, Marianne J.H. van Vugt

Publikováno v: Biochemical Journal, 349, 267-274
Biochemical Journal, 349, pp. 267-274

With the help of 16 chimaeras between human epidermal growth factor (hEGF) and human transforming growth factor alpha (hTGF alpha), a detailed analysis was performed on the epitope recognized by two polyclonal antibodies raised against hEGF, and one

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12a84282d00f6edb7d7e6309ddb1afd1
http://hdl.handle.net/2066/129328

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Phenotypic transformation of normal rat kidney cells by transforming growth factor β is not paralleled by enhanced production of a platelet-derived growth factor

Autor: A. Feijen, Walter van Rotterdam, Theodora M. J. Ward‐Van Oostwaard, Everardus J.J. van Zoelen

Publikováno v: European Journal of Biochemistry, 209, 89-94
European Journal of Biochemistry, 209, 1, pp. 89-94

Phenotypic transformation of normal rat kidney (NRK) cells requires the concerted action of multiple polypeptide growth factors. Serum-deprived NRK cells cultured in the presence of epidermal growth factor (EGF) become density-inhibited at confluence

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40ec71ee2c2a0af0632655df810a8aba
https://doi.org/10.1111/j.1432-1033.1992.tb17264.x

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