Zobrazeno 1 - 10 of 12 pro vyhledávání: '"Walter Z. Wang"'
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Akademický článek
Predicting ROR1/BCL2 combination targeted therapy of small cell carcinoma of the lung
Autor: Walter Z. Wang, Konstantin Shilo, Joseph M. Amann, Alyssa Shulman, Mohammad Hojjat-Farsangi, Håkan Mellstedt, Johan Schultz, Carlo M. Croce, David P. Carbone
Publikováno v: Cell Death and Disease, Vol 12, Iss 6, Pp 1-9 (2021)
Abstract Small cell lung cancer (SCLC) remains a deadly form of cancer, with a 5-year survival rate of less than 10 percent, necessitating novel therapies. Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is an oncofetal protein that is emergin
Externí odkaz: https://doaj.org/article/8e3d803832bd442687414f1eec0b50ef
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2
Small cell lung cancer: Subtypes and therapeutic implications
Autor: Walter Z. Wang, Alyssa Shulman, Joseph M. Amann, David P. Carbone, Philip N. Tsichlis
Publikováno v: Seminars in Cancer Biology. 86:543-554
Small cell lung cancer (SCLC) is an extremely aggressive neuroendocrine tumor, accounting for approximated 13% of all lung cancer cases. SCLC is characterized by rapid growth and early metastasis. Despite marked improvements in the number and efficac
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34dc32783b77aba3a9c0520ad7ce649b
https://doi.org/10.1016/j.semcancer.2022.04.001
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6
STK11/LKB1 Loss of Function Is Associated with Global DNA Hypomethylation and
Autor: Michael J, Koenig, Bernice A, Agana, Jacob M, Kaufman, Michael F, Sharpnack, Walter Z, Wang, Christoph, Weigel, Fabio C P, Navarro, Joseph M, Amann, Nicole, Cacciato, Rajeswara Rao, Arasada, Mark B, Gerstein, Vicki H, Wysocki, Christopher, Oakes, David P, Carbone
Publikováno v: Cancer Res
STK11 (Liver Kinase B1, LKB1) is the fourth-most frequently mutated gene in lung adenocarcinoma, with loss of function observed in up to 30% of all cases. Our previous work identified a 16-gene signature for LKB1 loss of function through mutational a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bd874e66a79c0db15d09866140de697a
https://pubmed.ncbi.nlm.nih.gov/34045189
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7
Soluble guanylate cyclase activation during ischemic injury in mice protects against postischemic inflammation at the mitochondrial level
Autor: Meifang Wang, Walter Z. Wang, Derek Wang, Allan W. Jones, Ronald J. Korthuis
Publikováno v: American Journal of Physiology-Gastrointestinal and Liver Physiology. 310:G747-G756
The aim was to determine whether treatment with BAY 60-2770, a selective activator of oxidized soluble guanylate cyclase (sGC), near the end of an ischemic event would prevent postischemic inflammation and mitochondrial dysfunction in wild-type (WT)
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be093f29b85818319c1bfbd537153a4b
https://doi.org/10.1152/ajpgi.00323.2015
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8
Preconditioning with soluble guanylate cyclase activation prevents postischemic inflammation and reduces nitrate tolerance in heme oxygenase-1 knockout mice
Autor: Allan W. Jones, Ronald J. Korthuis, Meifang Wang, Walter Z. Wang, William Durante
Publikováno v: American Journal of Physiology-Heart and Circulatory Physiology. 305:H521-H532
Previously we have shown that, unlike wild-type mice (WT), heme oxygenase-1 knockout (HO-1−/−) mice developed nitrate tolerance and were not protected from inflammation caused by ischemia-reperfusion (I/R) when preconditioned with a H2S donor. We
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b031735e03f0c8147e4062ad9fd25c72
https://doi.org/10.1152/ajpheart.00810.2012
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