Výsledky vyhledávání - "Walter Y. Chan"

Characterization of a Novel, Linear Radioiodinated Vasopressin Antagonist: An Excellent Radioligand for Vasopressin V1a Receptors

Autor: Yvan Arsenijevic, Florian Holsboer, Serge Jard, Jean Jacques Dreifuss, Walter Y. Chan, Krysztof Bankowski, Claude Barberis, Maurice Manning, Stephan S. Schlosser, J. Elands, Marie-Noëlle Balestre, Eliane Tribollet

Publikováno v: Neuroendocrinology. 62:135-146

We report on the pharmacological properties of a potent and selective linear vasopressin (AVP) V1a receptor antagonist HO-Phenylacetyl1-D-Tyr(Me)2-Phe3-Gln4-Asn5-Arg6-Pro7-Arg8-NH2 (HO-LVA). Iodinated on the phenolic substituent at position 1, [125I]

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::065accd8f12603ee3a059eafa1ec779a
https://doi.org/10.1159/000126998

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Oxytocin analogues with non-coded amino acid residues in position 8: [8-Neopentylglycine]oxytocin and [8-cycloleucine]oxytocin

Autor: Walter Y. Chan, Jan Pospíšek, Victor J. Hruby, Jiřina Slaninová, Jan Hlaváček

Publikováno v: Collection of Czechoslovak Chemical Communications. 52:2317-2325

[8-Neopentylglycine]oxytocin (II) and [8-cycloleucine]oxytocin (III) were prepared by a combination of solid-phase synthesis and fragment condensation. Both analogues exhibited decreased uterotonic potency in vitro, each being about 15-30% that of ox

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8acea75ba85271030b464f54fda960cc
https://doi.org/10.1135/cccc19872317

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