Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Walter Van den Broeck"'
Autor:
Geneviève Vandercruyssen, Origène Nyanguile, Leen Vijgen, Frederik Pauwels, Pascale Dehertogh, Koen Dockx, Hendrik L. De Bondt, Wendy Mostmans, Benoit Devogelaere, Gregory Fanning, Vendeville Sandrine Marie Hele, Pierre Raboisson, Oliver Lenz, Frederic Delouvroy, Ann Vos, Koen Vandyck, Katrien Vermeiren, Erna Cleiren, Walter Van den Broeck, Jan Martin Berke, Kenneth Simmen, Maxwell D. Cummings
Publikováno v:
Journal of Virology. 84:2923-2934
The RNA-dependent RNA polymerase (NS5B) of hepatitis C virus (HCV) is an unusually attractive target for drug discovery since it contains five distinct drugable sites. The success of novel antiviral therapies will require nonnucleoside inhibitors to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc7fe42c112a586f3f503effe1181796
https://doi.org/10.1128/jvi.01980-09
https://doi.org/10.1128/jvi.01980-09
Autor:
David McGowan, Origène Nyanguile, Maxwell D. Cummings, Sandrine Vendeville, Koen Vandyck, Walter Van den Broeck, Carlo W. Boutton, Hendrik De Bondt, Ludo Quirynen, Katie Amssoms, Jean-François Bonfanti, Stefaan Last, Klara Rombauts, Abdellah Tahri, Lili Hu, Frédéric Delouvroy, Katrien Vermeiren, Geneviève Vandercruyssen, Liesbet Van der Helm, Erna Cleiren, Wendy Mostmans, Pedro Lory, Geert Pille, Kristof Van Emelen, Gregory Fanning, Frederik Pauwels, Tse-I Lin, Kenneth Simmen, Pierre Raboisson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:2492-2496
Optimization through parallel synthesis of a novel series of hepatitis C virus (HCV) NS5B polymerase inhibitors led to the identification of ( R )-11-(4-benzyloxy-2-fluorophenyl)-6-hydroxy-3,3-dimethyl-10-(6-methylpyridine-2-carbonyl)-2,3,4,5,10,11-h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8521efff0fc4c0c065284cf8f74ff171
https://doi.org/10.1016/j.bmcl.2009.03.035
https://doi.org/10.1016/j.bmcl.2009.03.035
Autor:
Kenneth Simmen, Pierre Raboisson, Frederic Delouvroy, Maxwell D. Cummings, Wendy Mostmans, Tania Ivens, Pascale Dehertogh, Liesbet van der Helm, Geneviève Vandercruyssen, Origène Nyanguile, Walter Van den Broeck, Carlo Boutton, Jean Francois Bonfanti, Frederik Pauwels, Ludo Maria Marcel Quirynen
Publikováno v:
Antimicrobial Agents and Chemotherapy. 52:4420-4431
The exogenous control of hepatitis C virus (HCV) replication can be mediated through the inhibition of the RNA-dependent RNA polymerase (RdRp) activity of NS5B. Small-molecule inhibitors of NS5B include nucleoside and nonnucleoside analogs. Here, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02bd3cdba00a3b0ff19a49c2c9c34293
https://doi.org/10.1128/aac.00669-08
https://doi.org/10.1128/aac.00669-08
Autor:
Walter Van den Broeck
This chapter first explores what types of drug targets, treatment options, and screening strategies are the most successful to discover new small molecule drugs. Although target-based screening has certainly led to many successes, it failed more than
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9574cd66005e14c0527294a39319e7d5
https://doi.org/10.1016/b978-0-12-417205-0.00003-1
https://doi.org/10.1016/b978-0-12-417205-0.00003-1
Autor:
Marc René De Jonge, Paul J. Lewi, Yulia Volovik, Luc Koymans, Marie Pierre de Béthune, Walter Van den Broeck, Frits Daeyaert, Frédéric Vanhoutte, Jan Heeres, Paul A. J. Janssen, Maarten Vinkers, Jef Peeters, Herman Borghys, Kaylan Das, Hilde Bohets, Edward Arnold, Koen Andries, Jos Leempoels, Arthur D. Clark, Gerben Albert Eleutherius Van 'T Klooster, Philip Timmerman
Publikováno v:
Drugs in R & D. 5:245-257
Objective: To investigate the important factors that determine the bioavailability and the antiviral activity of the diaryltriazine (DATA) and diarylpyrimidine (DAPY) non-nucleoside reverse transcriptase inhibitors (NNRTIs) of HIV-1 in animal species
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e15438d986f28df08a9129b3a88abd9a
https://doi.org/10.2165/00126839-200405050-00001
https://doi.org/10.2165/00126839-200405050-00001
Autor:
Ludo Stynen, Walter van den Broeck
Publikováno v:
World Literature Today. 73:348
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b7db4c4f7defcc5e6add81f6d420bd7
https://doi.org/10.2307/40154778
https://doi.org/10.2307/40154778
Autor:
Lewi, Paul, Arnold, Eddy, Andries, Koen, Bohets, Hilde, Borghys, Herman, Clark, Arthur, Daeyaert, Frits, Das, Kalyan, de Béthune, Marie-Pierre, Marc de Jonge, Heeres, Jan, Koymans, Luc, Leempoels, Jos, Peeters, Jef, Timmerman, Philip, Walter Van den Broeck, Vanhoutte, Frédéric, Klooster, Gerben van‘t, Vinkers, Maarten, Volovik, Yulia
Publikováno v:
Drugs in R&D; 2004, Vol. 5 Issue 5, p245-257, 13p
Autor:
Arie Staal, Walter van den Broeck
Publikováno v:
World Literature Today. 68:584
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b62f76fffd12e243acd42204b4e39b99
https://doi.org/10.2307/40150481
https://doi.org/10.2307/40150481
Autor:
Ludo Stynen, Walter van den Broeck
Publikováno v:
World Literature Today. 67:841
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80e92bc6e4d8a669b66a7823a8b45eed
https://doi.org/10.2307/40149712
https://doi.org/10.2307/40149712
Autor:
Marc De Ryck, Albert Wauquier, Walter Van den Broeck, Paul A. J. Janssen, W. Melis, Jef Van Loon
Publikováno v:
Electroencephalography and clinical neurophysiology. 69(6)
Intravenous alfentanil was administered as a constant 1 h infusion to 6 dogs. Before, during and up to 3 h after infusion, the effects of 3 doses (0.001, 0.004 and 0.016 mg/kg/min) on 6 quantitative EEG measures (zero-crossing frequency, root mean sq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf585e5e20625035ccc9f61f895b3f9c
https://pubmed.ncbi.nlm.nih.gov/2453332
https://pubmed.ncbi.nlm.nih.gov/2453332