Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Walter Trizna"'
Autor:
Donald P. McDonnell, John D. Norris, Dmitri Kazmin, Scott K. Thompson, Jaclyn R. Patterson, Marlys Hammond, Walter Trizna, Nicholas J. Laping, Jeffrey D. Bray, Christine G. Schnackenberg, Daniel E. Frigo, Andrea B. Sherk
Androgens, through their actions on the androgen receptor (AR), are required for the development of the prostate and contribute to the pathologic growth dysregulation observed in prostate cancers. Consequently, androgen ablation has become an essenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95e83eb3282c67e787f8942ba5a7c35a
https://doi.org/10.1158/0008-5472.c.6498402
https://doi.org/10.1158/0008-5472.c.6498402
Autor:
Donald P. McDonnell, John D. Norris, Dmitri Kazmin, Scott K. Thompson, Jaclyn R. Patterson, Marlys Hammond, Walter Trizna, Nicholas J. Laping, Jeffrey D. Bray, Christine G. Schnackenberg, Daniel E. Frigo, Andrea B. Sherk
Supplementary Data from Development of a Small-Molecule Serum- and Glucocorticoid-Regulated Kinase-1 Antagonist and Its Evaluation as a Prostate Cancer Therapeutic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd34ad071b42869122db0e920ae8004b
https://doi.org/10.1158/0008-5472.22377012.v1
https://doi.org/10.1158/0008-5472.22377012.v1
Autor:
Rakesh Nagilla, Sharada Manns, Eugene L. Stewart, Marlys Hammond, Tram H. Hoang, Scott K. Thompson, Walter Trizna, Chaya Duraiswami, Eugene T. Grygielko, Thuy B. Tran, James S. Frazee, Kevin P. Madauss, Johnson Latisha C, Shawn P. Williams, Lindsay E. Glace, David G. Washburn, Jeffrey D. Bray
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:4664-4668
We have designed and synthesized a novel series of pyrrolidinones as progesterone receptor partial agonists. Compounds from this series had improved AR selectivity, rat pharmacokinetic properties, and in vivo potency compared to the lead compound. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e117925c53a26178fac52da1fa94885
https://doi.org/10.1016/j.bmcl.2009.06.081
https://doi.org/10.1016/j.bmcl.2009.06.081
Publikováno v:
European Journal of Pharmacology. 345:229-232
[ 125 I]Endothelin-1 bound with high affinity to a single site on both brush border membranes ( K d =192±26 pM, B max =314±49 fmol/mg) and basolateral membranes ( K d =94.7±3.4 pM, B max =612±107 fmol/mg) isolated from rat renal cortex. Competiti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63aebf93f0f7339a91f1fb89d86a98f0
https://doi.org/10.1016/s0014-2999(98)00090-9
https://doi.org/10.1016/s0014-2999(98)00090-9
Autor:
Marlys Hammond, David G. Washburn, Angela Smallwood, Tram H. Hoang, Nicholas J. Laping, Rebecca Trejo, Hiroko Nakamura, James S. Frazee, Martha S. Head, Scott K. Thompson, Kendra E. Hightower, Charlene Wu, Rakesh Nagilla, Jaclyn R. Patterson, Melanie Nord, Walter Trizna, Baoguang Zhao, Sharada Manns, Leonard M. Azzarano, Christine G. Schnackenberg
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(15)
The lead serum and glucocorticoid-related kinase 1 (SGK1) inhibitors 4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid (1) and {4-[5-(2-naphthalenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]phenyl}acetic acid (2) suffer from low DNAUC values in rat, due i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::523f8d46c823349d7ef17b1b17b5356f
https://pubmed.ncbi.nlm.nih.gov/19497745
https://pubmed.ncbi.nlm.nih.gov/19497745
Autor:
Eugene T. Grygielko, Shawn P. Williams, Lindsay E. Glace, Jeffrey D. Bray, Chaya Duraiswami, James S. Frazee, Kevin P. Madauss, David G. Washburn, Tram H. Hoang, Leahann Lapinski, Walter Trizna, Nicholas J. Laping, Scott K. Thompson
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(16)
Using the X-ray crystal structure of an amide-based progesterone receptor (PR) partial agonist bound to the PR ligand binding domain, a novel PR partial agonist class containing a pyrrolidine ring was designed. Members of this class of N-alkylpyrroli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6097498d950430c3690a93280e236dee
https://pubmed.ncbi.nlm.nih.gov/19595590
https://pubmed.ncbi.nlm.nih.gov/19595590
Synthesis and SAR of amino acid-derived heterocyclic progesterone receptor full and partial agonists
Autor:
Jaclyn R. Patterson, Scott K. Thompson, Harvey E. Fries, Eugene T. Grygielko, Walter Trizna, Tram H. Hoang, Jeffrey D. Bray, Nicholas J. Laping, Douglas J. Minick, Melanie Nord, Lindsay E. Glace, Rakesh Nagilla, Marlys Hammond, Sharada Manns, David G. Washburn
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(10)
Two classes of amino acid-derived heterocyclic progesterone receptor ligands were developed to address the metabolic issues posed by the dimethyl amide functionality of the lead compound (1). The tetrazole-derived ligands behaved as potent partial ag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b908a6958d1dc4b3fe1c567457b4850
https://pubmed.ncbi.nlm.nih.gov/19376703
https://pubmed.ncbi.nlm.nih.gov/19376703
Autor:
Marlys Hammond, Walter Trizna, Andrea B. Sherk, Donald P. McDonnell, Nicholas J. Laping, Jeffrey D. Bray, Daniel E. Frigo, Dmitri Kazmin, Scott K. Thompson, Christine G. Schnackenberg, John D. Norris, Jaclyn R. Patterson
Publikováno v:
Cancer research. 68(18)
Androgens, through their actions on the androgen receptor (AR), are required for the development of the prostate and contribute to the pathologic growth dysregulation observed in prostate cancers. Consequently, androgen ablation has become an essenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ecb1c34b02d745a7f1396419a76c34b
https://pubmed.ncbi.nlm.nih.gov/18794135
https://pubmed.ncbi.nlm.nih.gov/18794135
Autor:
Walter Trizna, Richard M. Edwards
Publikováno v:
Pharmacology. 41:149-152
The effects of endothelin-1, -2 and -3 (ET-1, -2, -3) on lumen diameter of intracerebral arterioles isolated from rat brain were examined. All three ETs produced concentration-dependent decreases in lumen diameter with EC50 values of 0.7, 1.5 and 58
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5a253e027604938bfe3e0eeff9a5615
https://doi.org/10.1159/000138711
https://doi.org/10.1159/000138711
Autor:
Richard M. Edwards, Walter Trizna
Publikováno v:
Journal of the American Society of Nephrology : JASN. 4(5)
The inhibition of nitric oxide production has been shown to reduce RBF. The effects of the nitric oxide synthase inhibitors, N omega-nitro-L-arginine and NG-monomethyl-L-arginine, on afferent and efferent arterioles isolated from rabbit kidneys were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::746ad49e6215f83c35e8bd0f9448854a
https://pubmed.ncbi.nlm.nih.gov/7508276
https://pubmed.ncbi.nlm.nih.gov/7508276