Zobrazeno 1 - 10
of 199
pro vyhledávání: '"Walter Sebald"'
Autor:
Axel Seher, Charlotte Lagler, Thorsten Stühmer, Urs Dietmar Achim Müller-Richter, Alexander Christian Kübler, Walter Sebald, Thomas Dieter Müller, Joachim Nickel
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0174884 (2017)
Multiple myeloma (MM) represents a haematological cancer characterized by the pathological hyper proliferation of antibody-producing B-lymphocytes. Patients typically suffer from kidney malfunction and skeletal disorders. In the context of MM, the tr
Externí odkaz:
https://doaj.org/article/3990fafe94fc45b0bc0c29833b01d56b
Autor:
Juliane E. Fiebig, Stella E. Weidauer, Li-Yan Qiu, Markus Bauer, Peter Schmieder, Monika Beerbaum, Jin-Li Zhang, Hartmut Oschkinat, Walter Sebald, Thomas D. Mueller
Publikováno v:
Molecules, Vol 18, Iss 10, Pp 11658-11682 (2013)
Bone Morphogenetic Proteins (BMPs) are secreted protein hormones that act as morphogens and exert essential roles during embryonic development of tissues and organs. Signaling by BMPs occurs via hetero-oligomerization of two types of serine/threonine
Externí odkaz:
https://doaj.org/article/f55b197c51ab4300b27ecbbccd7d73cb
Autor:
Jin-Li Zhang, Lucy J Patterson, Li-Yan Qiu, Daria Graziussi, Walter Sebald, Matthias Hammerschmidt
Publikováno v:
PLoS ONE, Vol 5, Iss 9, p e12846 (2010)
BACKGROUND: Crossveinless-2 (CV2) is an extracellular BMP modulator protein of the Chordin family, which can either enhance or inhibit BMP activity. CV2 binds to BMP2 via subdomain 1 of the first of its five N-terminal von Willebrand factor type C do
Externí odkaz:
https://doaj.org/article/98b1f655be2547cf8fe12acb272bb1be
Publikováno v:
PLoS ONE, Vol 5, Iss 9, p e744 (2010)
BACKGROUND: Members of the TGF-β superfamily are characterized by a highly promiscuous ligand-receptor interaction as is readily apparent from the numeral discrepancy of only seven type I and five type II receptors available for more than 40 ligands
Externí odkaz:
https://doaj.org/article/3631c65af937427b94eff47b4e9c1c23
Autor:
Petra Seemann, Anja Brehm, Jana König, Carsten Reissner, Sigmar Stricker, Pia Kuss, Julia Haupt, Stephanie Renninger, Joachim Nickel, Walter Sebald, Jay C Groppe, Frank Plöger, Jens Pohl, Mareen Schmidt-von Kegler, Maria Walther, Ingmar Gassner, Cristina Rusu, Andreas R Janecke, Katarina Dathe, Stefan Mundlos
Publikováno v:
PLoS Genetics, Vol 5, Iss 11, p e1000747 (2009)
Signaling output of bone morphogenetic proteins (BMPs) is determined by two sets of opposing interactions, one with heterotetrameric complexes of cell surface receptors, the other with secreted antagonists that act as ligand traps. We identified two
Externí odkaz:
https://doaj.org/article/8d0c86fc903b433fb9ac4193b9a43512
Publikováno v:
Journal of Bone and Mineral Metabolism. 37:199-205
The antagonist-specific regulation in tissue engineering constitutes important attempts to achieve an improved and rapid bone regeneration by controlling the natural biological response of the natural body growth factors. L51P is molecularly engineer
Autor:
Mathias Kottmair, Heike M. Hermanns, Thomas Müller, Carmen M. Schäfer, Werner Schmitz, Maja Gjorgjevikj, Viswanadham Duppatla, Walter Sebald
Publikováno v:
Bioconjugate Chemistry. 25:52-62
IL-4 signaling into a cell occurs via assembly of a receptor complex that consists of a high-affinity IL-4Rα chain and a low affinity chain, where the low-affinity chain is either γc or IL-13Rα1. It has been previously shown that mutational disrup
Autor:
Wataru Sonoyama, Kazuki Nema, Hai Thanh Pham, Takuo Kuboki, Yasutaka Oida, Kazuo Hirota, Kazushige Sugama, Emilio Satoshi Hara, Katushi Yamamoto, Mitsuaki Ono, Walter Sebald
Publikováno v:
Cells Tissues Organs. 198:367-376
Objective:Escherichia coli-derived recombinant human bone morphogenetic protein-2 (E-BMP-2) has been shown to be as effective as mammalian cell-derived BMP-2. However, several in vitro and in vivo experiments are still necessary to validate the effec
Autor:
Walter Sebald, Frank M. Klenke, Wilhelm Hofstetter, Hans-Jörg Sebald, Christoph E. Albers, Mark Siegrist
Publikováno v:
Acta Biomaterialia. 8:3816-3820
Bone morphogenetic proteins (BMP) have been used successfully by orthopedic clinicians to augment bone healing. However, these osteoinductive proteins must be applied at high concentrations to induce bone formation. The limited therapeutic efficacy m
Autor:
Walter Sebald, Mamie Mizusaki Iyomasa, Helton Luiz Aparecido Defino, João Paulo Mardegan Issa, Joaquim Coutinho Netto, Yamba Carla Lara Pereira, Maria Vitória Lopes Badra Bentley, Edilson Ervolino
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Background: The aim of this work was to study the new bone tissue formation af- ter bone morphogenetic protein type 2 (rhBMP-2) and P-1 application, using 5 and 10 lg of each, combined to a material carrier, in critical bone defects. Methods: It was