Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Walter Schuler"'
Publikováno v:
CHIMIA, Vol 73, Iss 7-8 (2019)
The macrolide rapamycin ( 1 ) was first described as an antifungal agent in 1975. Even though its biological target and the molecular details were yet to be discovered, rapamycin attracted our interest in the early 90s based on its reported immunosup
Externí odkaz:
https://doaj.org/article/c408d6f0fec74c369ecded182131a489
Autor:
Frank Stegmeier, Georg Lenz, Markus Warmuth, Yung-mae Yao, Bernd Dörken, Walter Schuler, Nigel J. Waters, Peter Lenz, Liqing Chen, Alice Loo, Andreas Enns, Boris A. Ratsch, Huaping Tang, Tara L. Naylor
Supplemental Methods and Materials, Supplementary Figures 1-12, Supplementary Figure Legends from Protein Kinase C Inhibitor Sotrastaurin Selectively Inhibits the Growth of CD79 Mutant Diffuse Large B-Cell Lymphomas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ab3e290c4aed7731fdb4851320cefd2
https://doi.org/10.1158/0008-5472.22389690.v1
https://doi.org/10.1158/0008-5472.22389690.v1
Autor:
Juergen Wagner, Eric Vangrevelinghe, Gerhard Zenke, Maurice Van Eis, Peter von Matt, Walter Schuler, Jean-Pierre Evenou
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(4)
The indolyl-naphthyl maleimide 7 is a potent inhibitor of the classical PKC isotypes α,β and shows excellent selectivity over the novel PKC isotypes δ,e,η,θ and other kinases belonging to the AGC family. The SAR around 7 as well as the physico-c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca9a4a01e296454c6510b490c76af280
https://pubmed.ncbi.nlm.nih.gov/28131714
https://pubmed.ncbi.nlm.nih.gov/28131714
Autor:
Anette Von Matt, Wilhelm Stark, Christoph Gaul, Juergen Wagner, Eric Vangrevelinghe, Lauren G. Monovich, Gabriele Rummel, Nicolas Soldermann, Walter Schuler, André Strauss, Sandra W. Cowan-Jacob, Maurice Van Eis, Jean-Pierre Evenou, Philipp Floersheim
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:7367-7372
The present study describes a novel series of ATP-competitive PKC inhibitors based on the 2,6-naphthyridine template. Example compounds potently inhibit the novel Protein Kinase C (PKC) isotypes δ, ε, η, θ (in particular PKCε/η, and display a 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a049780df31bdb8fa0ca7b096755c8fe
https://doi.org/10.1016/j.bmcl.2011.10.025
https://doi.org/10.1016/j.bmcl.2011.10.025
Autor:
Frank Stegmeier, Liqing Chen, Yung-mae Yao, Peter Lenz, Andreas Enns, Boris A. Ratsch, Huaping Tang, Nigel J. Waters, Markus Warmuth, Bernd Dörken, Georg Lenz, Walter Schuler, Alice Loo, Tara L. Naylor
Publikováno v:
Cancer Research. 71:2643-2653
The activated B-cell–like (ABC) subtype of diffuse large B-cell lymphoma (DLBCL) correlates with poor prognosis. The ABC subtype of DLBCL is associated with constitutive activation of the NF-κB pathway, and oncogenic lesions have been identified i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d6f0a58c87d1a87895e32ea23cde00a
https://doi.org/10.1158/0008-5472.can-10-2525
https://doi.org/10.1158/0008-5472.can-10-2525
Autor:
Murty A. R. C. Bulusu, Gerhard Zenke, Gerhard Schulz, Christophe Rochais, Thomas Tricotet, Andrea Steck, Peter Hiestand, Markus Bacher, Josef G. Meingassner, Trixie Wagner, Peter Waldstätten, Walter Schuler
Publikováno v:
Helvetica Chimica Acta. 92:839-889
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e33dca454c81bccc00430d59490cb326
https://doi.org/10.1002/hlca.200800436
https://doi.org/10.1002/hlca.200800436
Autor:
Reet Tees, Valerie Hungerford, Beate Kleuser, Sabine Geisse, Catherine Wioland, Corinne Wilt, Mauro Zurini, Grazyna Wieczorek, Marc Bigaud, Hermann Gram, Colette Kristofic, Volker Brinkmann, Franco Di Padova, Walter Schuler, Klaus Menninger
Publikováno v:
Transplantation. 77:717-726
BACKGROUND Anti-CD154 monoclonal antibodies (mAbs) cause long-term graft survival in preclinical allotransplantation experiments. This is the first report on the efficacy and safety of ABI793, a novel human anti-human CD154 mAb, in Cynomolgus renal t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::751df3982d86849e037dc8e83027643d
https://doi.org/10.1097/01.tp.0000116563.72763.83
https://doi.org/10.1097/01.tp.0000116563.72763.83
Autor:
Plamen Kossev, Mariusz A. Wasik, Leslie M. Shaw, Leona Fields, Magdalena Korecka, Joanne Joergensen, Walter Schuler, Miroslaw Majewski
Publikováno v:
Transplantation. 75:1710-1717
Background Posttransplant lymphoproliferative disorders (PTLDs) represent a life-threatening complication of standard immunosuppressive therapy. The impact of novel, rapamycin-related immunosuppressive drugs on the pathogenesis of PTLDs remains undef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fce1ce1002eb3d1da0ebccbc483bc263
https://doi.org/10.1097/01.tp.0000063934.89714.19
https://doi.org/10.1097/01.tp.0000063934.89714.19
Autor:
Matthew Thomas, Eric Vangrevelinghe, Nigel J. Waters, Greg Hollingworth, Elizabeth R. Sprague, Maurice Van Eis, Duncan Shaw, Nicholas Duggan, Takatoshi Kosaka, Walter Schuler, Nicolas Soldermann
Publikováno v:
Bioorganicmedicinal chemistry letters. 24(20)
A novel class of selective inhibitors of ROCK1 and ROCK2 has been identified by structural based drug design. PK/PD experiments using a set of highly selective Rho kinase inhibitors suggest that systemic Rho kinase inhibition is linked to a reversibl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb585d9aac5518864921887a4b05fa92
https://pubmed.ncbi.nlm.nih.gov/25248678
https://pubmed.ncbi.nlm.nih.gov/25248678
Autor:
Magdalena Korecka, Plamen Kossev, Leslie M. Shaw, Leslie E. Silberstein, Miroslaw Majewski, Walter Schuler, June Goldman, Peter C. Nowell, Mariusz A. Wasik, Shiyong Li, Jonni S. Moore
Publikováno v:
Proceedings of the National Academy of Sciences. 97:4285-4290
Whereas the standard immunosuppressive agents foster development of posttransplant lymphoproliferative disorders (PTLDs), the impact of RAD, a macrolide with potent immunosuppressive properties, and other immunosuppressive macrolides on these disorde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d509f532f2de72921cf984930494b3a
https://doi.org/10.1073/pnas.080068597
https://doi.org/10.1073/pnas.080068597