Supplementary Table 3 from Attenuation of microRNA-126 Expression That Drives CD34+38− Stem/Progenitor Cells in Acute Myeloid Leukemia Leads to Tumor Eradication

Autor: Linda Smit, Gert J. Ossenkoppele, Gerrit Jan Schuurhuis, Walter Pouwels, Arjo P. Rutten, Marjolein C. Olthof, Fedor Denkers, David C. de Leeuw

XLSX file - 15KB, MicroRNAs differentially expressed between LSC and HSC (at least 2 out of 3 patients): Upper: MicroRNA expression ratios between CD34+CD38-ALDHlow/dim(LSC) and CD34+CD38-ALDHhigh (HSC) populations obtained from microarray analysis.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::205a160304b367da8233636005be81c1
https://doi.org/10.1158/0008-5472.22400879.v1

Data from Attenuation of microRNA-126 Expression That Drives CD34+38− Stem/Progenitor Cells in Acute Myeloid Leukemia Leads to Tumor Eradication

Autor: Linda Smit, Gert J. Ossenkoppele, Gerrit Jan Schuurhuis, Walter Pouwels, Arjo P. Rutten, Marjolein C. Olthof, Fedor Denkers, David C. de Leeuw

Despite high remission rates after therapy, 60% to 70% of patients with acute myeloid leukemia (AML) do not survive 5 years after their initial diagnosis. The main cause of treatment failures may be insufficient eradication of a subpopulation of leuk

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b90833b30d62cbe27366d54f5243b459
https://doi.org/10.1158/0008-5472.c.6505712

Supplementary Table 4 from Attenuation of microRNA-126 Expression That Drives CD34+38− Stem/Progenitor Cells in Acute Myeloid Leukemia Leads to Tumor Eradication

Autor: Linda Smit, Gert J. Ossenkoppele, Gerrit Jan Schuurhuis, Walter Pouwels, Arjo P. Rutten, Marjolein C. Olthof, Fedor Denkers, David C. de Leeuw

XLSX file - 11KB, MicroRNA-126 is highly expressed in core binding factor AML: qRT-PCR results of miR-126 in CD34+CD38-ALDHlow/dim LSC and CD34+CD38+ALDHlow/dim leukemic progenitors in 18 AML patients. Cytogenetics indicates the presence of a CBF kar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0289ab5a2574ac15e921379c7d167de7
https://doi.org/10.1158/0008-5472.22400876

Generation of alloreactivity-reduced donor lymphocyte products retaining memory function by fully automatic depletion of CD45RA-positive cells

Autor: Walter Pouwels, Halvard Bonig, Kirsten Langeveld, J.J. Stenzel, Katharina Landwehr, Menno A.W.G. van der Hoorn, Nina Müller, Erhard Seifried

Publikováno v: Cytotherapy. 20(4)

Background aims For patients needing allogeneic stem cell transplantation but lacking a major histocompatibility complex (MHC)-matched donor, haplo-identical (family) donors may be an alternative. Stringent T-cell depletion required in these cases to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20ee77d069a72cb13c644cd95ad07b5b
https://pubmed.ncbi.nlm.nih.gov/29500069

Residual normal stem cells can be detected in newly diagnosed chronic myeloid leukemia patients by a new flow cytometric approach and predict for optimal response to imatinib

Autor: Gerrit Jan Schuurhuis, Jeroen Janssen, Wendy Deenik, Walter Pouwels, Jan J. Cornelissen, Karlijn G.M. Smolders, Gert J. Ossenkoppele, Angèle Kelder, B. van Kuijk

Publikováno v: Janssen, J J W M, Deenik, W, Smolders, K G M, van Kuijk, B J, Pouwels, W, Kelder, A, Cornelissen, J J, Schuurhuis, G J & Ossenkoppele, G J 2012, ' Residual normal stem cells can be detected in newly diagnosed chronic myeloid leukemia patients by a new flow cytometric approach and predict for optimal response to imatinib ', Leukemia, vol. 26, no. 5, pp. 977-984 . https://doi.org/10.1038/leu.2011.347
Leukemia, 26(5), 977-984. Nature Publishing Group

Insensitivity of chronic myeloid leukemia (CML) hematopoietic stem cells to tyrosine kinase inhibitors (TKIs) prevents eradication of the disease and may be involved in clinical resistance. For improved treatment results more knowledge about CML stem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8f3db36e1d785dd7263b4a27dfdda44
https://doi.org/10.1038/leu.2011.347