Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Walter P. Blackstock"'
Autor:
Jyoti S. Choudhary, Mark O. Collins, Christopher N. G. Anderson, Lu Yu, Seth G. N. Grant, Holger Husi, Walter P. Blackstock, Julia M. Brandon
Publikováno v:
Journal of Neurochemistry. 97:16-23
Characterization of the composition of the postsynaptic proteome (PSP) provides a framework for understanding the overall organization and function of the synapse in normal and pathological conditions. We have identified 698 proteins from the postsyn
Autor:
Zong-Xiang Xia, Walter P. Blackstock, Wang-Yi Liu, Joyti S Choudhary, Lu Yu, Jian-Hua Gan, Hong Xu, Jian Wu
Publikováno v:
Structure. 12:1015-1025
Trichomaglin is a protein isolated from root tuber of the plant Maganlin ( Trichosanthes Lepiniate , Cucurbitaceae). The crystal structure of trichomaglin has been determined by multiple-isomorphous replacement and refined at 2.2 A resolution. The X-
Autor:
Seth G. N. Grant, Walter P. Blackstock
Publikováno v:
The Journal of Neuroscience. 21:8315-8318
Proteomic tools offer a new platform for studies of complex biological functions involving large numbers and networks of proteins. Intracellular networks of proteins perform key functions in neurons and glia. The unicellular eukaryote Saccharomyces c
Publikováno v:
Trends in Biotechnology. 19:17-22
The use of mass spectrometry data to search molecular sequence databases is a well-established method for protein identification. The technique can be extended to searching raw genomic sequences, providing experimental confirmation or correction of p
Publikováno v:
PROTEOMICS. 1:651-667
The public availability of a draft assembly of the human genome has enabled us to demonstrate, for the first time, the feasibility of searching a complete, unmasked eukaryotic genome using uninterpreted mass spectrometry data. A complex LC-MS/MS data
Autor:
G M Gibb, Walter P. Blackstock, Jean-Marc Gallo, Simon Lovestone, Brian H. Anderton, Joanna Betts, James Connell, Mike Hutton
Publikováno v:
FEBS Letters. 493:40-44
In vitro phosphorylation of recombinant wild-type 2N4R tau and FTDP-17 exonic mutant forms P301L, V337M and R406W by glycogen synthase kinase 3beta (GSK3beta) was examined by two dimensional phosphopeptide mapping analysis on thin layer cellulose pla
Autor:
Jacques Paiement, John J.M. Bergeron, Adele Rowley, Eric Chevet, David Y. Thomas, Malcolm Ward, Alexander W. Bell, Dipti Chotai, Walter P. Blackstock, Ali Fazel, Jennifer N. Gushue, Alan Peter Lewis, Hamzah N.M. Freeman, Sandrine Palcy, Roberto Solari, Jyoti S. Choudhary, Myriam Lafreniere-Roula
Publikováno v:
Journal of Biological Chemistry. 276:5152-5165
A mass spectrometric analysis of proteins partitioning into Triton X-114 from purified hepatic Golgi apparatus (84% purity by morphometry, 122-fold enrichment over the homogenate for the Golgi marker galactosyl transferase) led to the unambiguous ide
Autor:
Brian H. Anderton, Michael M. Hoffmann, Simon Lovestone, Winfried Maerz, Joanna C. Betts, G M Gibb, Walter P. Blackstock, J. Pearce
Publikováno v:
FEBS Letters. 485:99-103
Previously published data have shown an allele-specific variation in the in vitro binding of apolipoprotein E (apoE) to tau, which prompted the hypothesis that apoE binding may protect tau from phosphorylation, apoE3 being more efficient than apoE4.
Autor:
María Molina, César Nombela, Malcolm A. Ward, Concha Gil, Walter P. Blackstock, Satty Bains, Mercedes Pardo
Publikováno v:
Electrophoresis. 21:3396-3410
In fungi, cell shape is determined by the presence of a rigid cell wall which separates the cell from the extracellular medium. This highly dynamic structure is essential for the maintenance of cell integrity and is involved in several phenomena such
Autor:
Walter P. Blackstock
Publikováno v:
Trends in Biotechnology. 18:12-17
Mass spectrometry and database searching are at the core of proteomics. The emphasis on matrix-assisted laser desorption–ionization for high-throughput experiments might change as greater emphasis is placed on sequence. Two-dimensional chromatograp