Zobrazeno 1 - 10 of 113 pro vyhledávání: '"Walter Newman"'
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Akademický článek
Validation of a DKK1 RNAscope chromogenic in situ hybridization assay for gastric and gastroesophageal junction adenocarcinoma tumors
Autor: Charles Caldwell, James B. Rottman, Will Paces, Elizabeth Bueche, Sofia Reitsma, Joseph Gibb, Vitria Adisetiyo, Michael S. Haas, Heidi Heath, Walter Newman, Jason Baum, Roberto Gianani, Michael H. Kagey
Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Dickkopf-1 (DKK1) is a secreted modulator of Wnt signaling that is frequently overexpressed in tumors and associated with poor clinical outcomes. DKN-01 is a humanized monoclonal therapeutic antibody that binds DKK1 with high affinity and ha
Externí odkaz: https://doaj.org/article/386bfb9934384f32ac9a8bd2228acb37
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2
DKK1 drives immune suppressive phenotypes in intrahepatic cholangiocarcinoma and can be targeted with anti‐DKK1 therapeutic DKN ‐01
Autor: Edward J. Jarman, Marta Horcas‐Lopez, Scott H. Waddell, Stephanie MacMaster, Konstantinos Gournopanos, Daniel Y. H. Soong, Kamila I. Musialik, Panagiota Tsokkou, Minn‐E Ng, William A. Cambridge, David H. Wilson, Michael H. Kagey, Walter Newman, Jeffrey W. Pollard, Luke Boulter
Publikováno v: Jarman, E, Horcas Lopez, M, Waddell, S, MacMaster, S, Gournopanos, K, Soong, D, I. Musialik, K, Tsokkou, P, Ng, M-E, Cambridge, W, Wilson, D, Kagey, M H, Newman, W, Pollard, J W & Boulter, L 2022, ' DKK1 drives immune suppressive phenotypes in intrahepatic cholangiocarcinoma and can be targeted with anti-DKK1 therapeutic DKN-01 ', Liver International . https://doi.org/10.1111/liv.15383
Background and aims: Dickkopf-1 (DKK1) is associated with poor prognosis in intrahepatic cholangiocarcinoma (iCCA), but the mechanisms behind this are unclear. Here, we show that DKK1 plays an immune regulatory role in vivo and inhibition reduces tum
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::668e3173330f4883253652784be38a86
https://doi.org/10.1111/liv.15383
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4
Data from mDKN-01, a Novel Anti-DKK1 mAb, Enhances Innate Immune Responses in the Tumor Microenvironment
Autor: Walter Newman, James B. Rottman, Franziska Schuerpf, Heidi Heath, Michael H. Kagey, Michael S. Haas
Dickkopf-1 (DKK1), a secreted modulator of Wnt signaling, is overexpressed in many cancers, is often associated with worse clinical outcomes, and has been shown to have immunosuppressive effects. DKN-01 is an IgG4 clinical stage antibody that potentl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2a770e7b3842bd86663344e6274479bf
https://doi.org/10.1158/1541-7786.c.6545285.v1
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mDKN-01, a Novel Anti-DKK1 mAb, Enhances Innate Immune Responses in the Tumor Microenvironment
Autor: Heidi Heath, Michael Haas, Michael H. Kagey, Walter Newman, James B. Rottman, Franziska Schuerpf
Publikováno v: Molecular Cancer Research. 19:717-725
Dickkopf-1 (DKK1), a secreted modulator of Wnt signaling, is overexpressed in many cancers, is often associated with worse clinical outcomes, and has been shown to have immunosuppressive effects. DKN-01 is an IgG4 clinical stage antibody that potentl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ff1212be4303ae0d32d7b43ff110725
https://doi.org/10.1158/1541-7786.mcr-20-0799
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