Zobrazeno 1 - 10 of 32 pro vyhledávání: '"Walter Mitchell"'
2
Application of Cryopreserved Human Intestinal Mucosa and Cryopreserved Human Enterocytes in the Evaluation of Herb-Drug Interactions: Evaluation of CYP3A Inhibitory Potential of Grapefruit Juice and Commercial Formulations of Twenty-Nine Herbal Supplements
Autor: Carol Loretz, Ming-Chih David Ho, Walter Mitchell, Albert P. Li, Novera Alam
Publikováno v: Drug Metabolism and Disposition. 48:1084-1091
Commercial formulations of 29 commonly used herbal supplements (HSs) and grapefruit juice were evaluated for drug interaction potential via quantification of their CYP3A inhibitory potential in two in vitro experimental models of human small intestin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcacb9ed8dfbd01553d3a3de784999c0
https://doi.org/10.1124/dmd.120.000033
Zobrazit plný text záznamu
3
Inter-individual and inter-regional variations in enteric drug metabolizing enzyme activities: Results with cryopreserved human intestinal mucosal epithelia (CHIM) from the small intestines of 14 donors
Autor: Zhengyin Yan, Susan Wong, Novera Alam, Walter Mitchell, Jane R. Kenny, Ming-Chih D Ho, Albert P. Li, Cornelis E. C. A. Hop
Publikováno v: Pharmacology Research & Perspectives
We have previously reported successful isolation and cryopreservation of human intestinal mucosa (CHIM) with retention of viability and drug metabolizing enzyme activities. Here we report the results of the quantification of drug metabolizing enzyme
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8b7ae9d2e2243670bd2de6a5b126259
https://pubmed.ncbi.nlm.nih.gov/32851819
Zobrazit plný text záznamu
5
In vitro experimental system for the evaluation of intestinal drug metabolism, drug‐drug interactions, and drug toxicity
Autor: Albert P. Li, Novera Alam, Carol Loretz, David Ho, Kirsten Amaral, Qian Yang, Walter Mitchell
Publikováno v: The FASEB Journal. 33
The small intestines play an important role in the fates and biological effects of orally administered drug. Primary enterocyte isolates retaining in vivo drug metabolizing enzyme activities repres...
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a4eb850da12682e64a748a90ef84a5f0
https://doi.org/10.1096/fasebj.2019.33.1_supplement.814.4
Zobrazit plný text záznamu
9
Cryopreserved Human Intestinal Mucosal Epithelium: A Novel In Vitro Experimental System for the Evaluation of Enteric Drug Metabolism, Cytochrome P450 Induction, and Enterotoxicity
Autor: Walter Mitchell, Novera Alam, Qian Yang, Carol Loretz, Albert P. Li, Ming-Chih David Ho, Kirsten Amaral
Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 46(11)
We report here a novel in vitro enteric experimental system, cryopreserved human intestinal mucosa (CHIM), for the evaluation of enteric drug metabolism, drug-drug interaction, drug toxicity, and pharmacology. CHIM was isolated from the small intesti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e64eca614fd824bac24dbc25a3e713c
https://pubmed.ncbi.nlm.nih.gov/30006371
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje