Formation of DNA Adducts by 1-Methoxy-3-indolylmethylalcohol, a Breakdown Product of a Glucosinolate, in the Mouse: Impact of the SULT1A1 Status—Wild-Type, Knockout or Humanised

Autor: Hansruedi Glatt, Sarah Yasmin Weißenberg, Anke Ehlers, Alfonso Lampen, Albrecht Seidel, Fabian Schumacher, Wolfram Engst, Walter Meinl

Publikováno v: International Journal of Molecular Sciences, Vol 25, Iss 7, p 3824 (2024)

We previously found that feeding rats with broccoli or cauliflower leads to the formation of characteristic DNA adducts in the liver, intestine and various other tissues. We identified the critical substances in the plants as 1-methoxy-3-indolylmethy

Externí odkaz: https://doaj.org/article/f8ec43083ae74669a074b02890305dc4

Strong impact of sulfotransferases on DNA adduct formation by 4‐aminobiphenyl in bladder and liver in mice

Autor: Yun Li, Zhidan Chen, Joseph D. Paonessa, Walter Meinl, Arup Bhattacharya, Hansruedi Glatt, Paul Vouros, Yuesheng Zhang

Publikováno v: Cancer Medicine, Vol 7, Iss 11, Pp 5604-5610 (2018)

Abstract Bladder cancer risk is 3‐4 times higher in men than women, but the reason is poorly understood. In mice, male bladder is also more susceptible than female bladder to 4‐aminobiphenyl (ABP), a major human bladder carcinogen; however, femal

Externí odkaz: https://doaj.org/article/0bd0fa53678549dd93c5657143a196ac

Decreased proteasomal cleavage at nitrotyrosine sites in proteins and peptides

Autor: Tilman Grune, Mauricio Mastrogiovanni, Alejandro Leyva, Nicolás Campolo, Carlos Batthyány, Silvina Bartesaghi, Walter Meinl, Rafael Radi, Christiane Ott, Florencia Tomasina

Publikováno v: Redox Biology, 46:102106
Redox Biology, Vol 46, Iss, Pp 102106-(2021)
Redox Biology

Removal of moderately oxidized proteins is mainly carried out by the proteasome, while highly modified proteins are no longer degradable. However, in the case of proteins modified by nitration of tyrosine residues to 3-nitrotyrosine (NO2Y), the role

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cead3b386a301dc8ae7a8aed33d70b4
https://repository.publisso.de/resource/frl:6432540

Impact of genetic modulation of SULT1A enzymes on DNA adduct formation by aristolochic acids and 3-nitrobenzanthrone

Autor: Annette M. Krais, Eszter Nagy, Volker M. Arlt, David H. Phillips, Walter Meinl, Iveta Mrizova, Simone Florian, Amin Mirza, František Bárta, Maggie Liu, Hansruedi Glatt, Marlies Thomann, Heinz H. Schmeiser, Klaus Kopka, Meirion Richards, Marie Stiborová

Publikováno v: Arlt, V M, Meinl, W, Florian, S, Nagy, E, Barta, F, Thomann, M, Mrizova, I, Krais, A M, Liu, M, Richards, M, Mirza, A, Kopka, K, Phillips, D H, Glatt, H, Stiborova, M & Schmeiser, H H 2017, ' Impact of genetic modulation of SULT1A enzymes on DNA adduct formation by aristolochic acids and 3-nitrobenzanthrone ', Archives of Toxicology, vol. 91, no. 4, pp. 1957-1975 . https://doi.org/10.1007/s00204-016-1808-6
Archives of Toxicology

Exposure to aristolochic acid (AA) causes aristolochic acid nephropathy (AAN) and Balkan endemic nephropathy (BEN). Conflicting results have been found for the role of human sulfotransferase 1A1 (SULT1A1) contributing to the metabolic activation of a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3fdc183e5db200f968b9012fc2e83a4
https://doi.org/10.1007/s00204-016-1808-6

The influence of the SULT1A status – wild-type, knockout or humanized – on the DNA adduct formation by methyleugenol in extrahepatic tissues of mice

Autor: Alfonso Lampen, S. Florian, Walter Meinl, Wolfram Engst, Kristin Herrmann, Hansruedi Glatt

Publikováno v: Toxicology Research. 5:808-815

Methyleugenol, present in herbs and spices, has demonstrated carcinogenic activity in the liver and, to a lesser extent, in extrahepatic tissues of rats and mice. It forms DNA adducts after hydroxylation and sulphation. As previously reported, hepati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf1a21cd0e78aaa2122dbbbc29c23579
https://doi.org/10.1039/c5tx00358j