Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Walter M. Kim"'
Autor:
Amit K. Gandhi, Zhen-Yu J. Sun, Yu-Hwa Huang, Walter M. Kim, Chao Yang, Gregory A. Petsko, Nicole Beauchemin, Richard S. Blumberg
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
The crystal structure of human CEACAM1 IgV oligomer and structural analyses provide insight into higher-order oligomerization involving GFCC’ face-mediated homodimerization, flexible ABED interfaces, and dynamic metal-ion bridging.
Externí odkaz:
https://doaj.org/article/6e72149b314d457caf892328a8eb9172
Autor:
Amit K. Gandhi, Zhen-Yu J. Sun, Walter M. Kim, Yu-Hwa Huang, Yasuyuki Kondo, Daniel A. Bonsor, Eric J. Sundberg, Gerhard Wagner, Vijay K. Kuchroo, Gregory A. Petsko, Richard S. Blumberg
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
To understand how hCEACAM1 transitions between monomeric and dimeric states that are required for its activity, Gandhi et al. investigate hCEACAM1 homodimeric, monomeric, and transition states and their behavior in solution. This study suggests the f
Externí odkaz:
https://doaj.org/article/1e98a0721d5041b7bcee1fce74ebca91
Autor:
Zhen-Yu J. Sun, Amit Gandhi, Walter M. Kim, Yasuyuki Kondo, Gerhard Wagner, Daniel A. Bonsor, Gregory A. Petsko, Vijay K. Kuchroo, Yu-Hwa Huang, Richard S. Blumberg, Eric J. Sundberg
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
T-cell immunoglobulin and mucin domain containing protein-3 (TIM-3) is an important immune regulator. Here, we describe a novel high resolution (1.7 Å) crystal structure of the human (h)TIM-3 N-terminal variable immunoglobulin (IgV) domain with boun
Publikováno v:
Seminars in Immunology. 42:101296
The type I membrane protein receptor carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) distinctively exhibits significant alternative splicing that allows for tunable functions upon homophilic binding. CEACAM1 is highly expressed in
Publikováno v:
Nature Medicine. 23:535-536
A new study identifies oncostatin M (OSM) as a potential biomarker and therapeutic target for anti-tumor necrosis factor (TNF)-refractory inflammatory bowel disease (IBD), and pinpoints mucosal stromal cells as key players in OSM-mediated inflammatio
Publikováno v:
Acta Crystallographica Section D: Biological Crystallography
P212121 crystals of SIV Nef core domain bound to a peptide fragment of the T-cell receptor ζ subunit exhibited noncrystallographic symmetry and nearly perfect pseudo-merohedral twinning simulating tetragonal symmetry. For a different peptide fragmen
Publikováno v:
Protein Expression and Purification. 36:40-47
We have constructed a dual expression vector for the production of recombinant proteins in both Escherichia coli and insect cells. In this vector, the baculoviral polyhedrin promoter was positioned upstream of the bacteriophage T7 promoter and the la
Autor:
Niklas Krupka, Richard S. Blumberg, Michal Pyzik, Inger Sandlie, Edda Fiebiger, Jan Terje Andersen, Walter M. Kim, Wayne I. Lencer, Derry C. Roopenian, Jerrold R. Turner, Jonathan N. Glickman, Timo Rath, Jonathan J. Hubbard, Kristi Baker
Publikováno v:
Gastroenterology. 152:S614
Autor:
Walter M, Kim, Alexander B, Sigalov
Publikováno v:
Multichain Immune Recognition Receptor Signaling
During the co-evolution of viruses and their hosts, the latter have equipped themselves with an elaborate immune system to defend themselves from the invading viruses. In order to establish a successful infection, replicate and persist in the host, v
Autor:
Alexander B. Sigalov, Walter M. Kim
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9780387097886
During the co-evolution of viruses and their hosts, the latter have equipped themselves with an elaborate immune system to defend themselves from the invading viruses. In order to establish a successful infection, replicate and persist in the host, v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6219e313e2d323966062f7d02719f402
https://doi.org/10.1007/978-0-387-09789-3_22
https://doi.org/10.1007/978-0-387-09789-3_22