Zobrazeno 1 - 10
of 133
pro vyhledávání: '"Walter M. Holleran"'
Publikováno v:
Journal of Lipid Research, Vol 49, Iss 4, Pp 697-714 (2008)
Many of the ichthyoses are associated with inherited disorders of lipid metabolism. These disorders have provided unique models to dissect physiologic processes in normal epidermis and the pathophysiology of more common scaling conditions. In most of
Externí odkaz:
https://doaj.org/article/cfa65d6843bf40e0949cdbee67e22aa7
Differentiation-associated expression of ceramidase isoforms in cultured keratinocytes and epidermis
Autor:
Evi Houben, Walter M. Holleran, Toshiaki Yaginuma, Cungui Mao, Lina M. Obeid, Vera Rogiers, Yutaka Takagi, Peter M. Elias, Yoshikazu Uchida
Publikováno v:
Journal of Lipid Research, Vol 47, Iss 5, Pp 1063-1070 (2006)
Ceramides (Cers) accumulate within the interstices of the outermost epidermal layers, or stratum corneum (SC), where they represent critical components of the epidermal permeability barrier. Although the SC contains substantial sphingol, indicative o
Externí odkaz:
https://doaj.org/article/066e53dc1f434628a473ca7c161d326f
Autor:
Yoshikazu Uchida, Satoru Murata, Matthias Schmuth, Martin J. Behne, Jeong Deuk Lee, Shinichi Ichikawa, Peter M. Elias, Yoshio Hirabayashi, Walter M. Holleran
Publikováno v:
Journal of Lipid Research, Vol 43, Iss 8, Pp 1293-1302 (2002)
Ceramides (Cers), critical for epidermal barrier function, also can inhibit keratinocyte proliferation, while glucosylceramides (GlcCers) exert pro-mitogenic effects. Since alterations in Cer-to-GlcCer ratios appear to modulate cellular growth versus
Externí odkaz:
https://doaj.org/article/19793dfe35e94525907bf3607f3cb45d
Autor:
Riaz A. Memon, Walter M. Holleran, Yoshikazu Uchida, Arthur H. Moser, Carl Grunfeld, Kenneth R. Feingold
Publikováno v:
Journal of Lipid Research, Vol 42, Iss 3, Pp 452-459 (2001)
The host response to infection and inflammation is associated with multiple alterations in lipid metabolism. We have shown that endotoxin [lipopolysaccharide (LPS)] stimulates hepatic sphingolipid synthesis and increases ceramide and glucosylceramide
Externí odkaz:
https://doaj.org/article/753725ae370d4cdda4d654f1a64eaa12
Autor:
Yoshikazu Uchida, Mariko Hara, Hiroyuki Nishio, Ellen Sidransky, Shintaro Inoue, Fujio Otsuka, Akemi Suzuki, Peter M. Elias, Walter M. Holleran, Sumiko Hamanaka
Publikováno v:
Journal of Lipid Research, Vol 41, Iss 12, Pp 2071-2082 (2000)
Epidermal ceramides (Cer) comprise a heterogeneous family of seven species, including two unique ω-hydroxylated Cer, that are key components of the stratum corneum (SC) intercellular lamellar membranes responsible for the epidermal permeability barr
Externí odkaz:
https://doaj.org/article/be5998e59209496ca480f03462d666bc
Publikováno v:
Journal of Lipid Research, Vol 40, Iss 5, Pp 861-869 (1999)
Although previous studies have demonstrated a crucial role for the enzyme β-glucocerebrosidase (GlcCer'ase) in the final steps of membrane structural maturation in mammalian stratum cornuem (SC) and epidermal homeostasis, the precise in vivo localiz
Externí odkaz:
https://doaj.org/article/21a7157d779a410eb3ce7a63d2f9b0c7
Autor:
Angela M. Farrell, Yoshikazu Uchida, M. Marek Nagiec, Ian R. Harris, Robert C. Dickson, Peter M. Elias, Walter M. Holleran
Publikováno v:
Journal of Lipid Research, Vol 39, Iss 10, Pp 2031-2038 (1998)
The enzyme serine palmitoyltransferase (SPT; EC 2.3.1.50), which catalyzes the first committed and rate-limiting step in sphingolipid synthesis, is up-regulated in the epidermis as part of the homeostatic repair in response to permeability barrier pe
Externí odkaz:
https://doaj.org/article/9e0311ba698e4f2190c3b08bdbd9401a
Publikováno v:
Journal of Lipid Research, Vol 39, Iss 2, Pp 277-285 (1998)
Ceramides, which derive from the hydrolysis of glucosylceramide (GlcCer), are the predominant lipid species in the stratum corneum and are critical for epidermal permeability barrier homeostasis. UDP-glucose:ceramide glucosyltransferase (GlcCer synth
Externí odkaz:
https://doaj.org/article/788a9bd9567d42a59273f3ab13d70509
Autor:
Ian R. Harris, Angela M. Farrell, Walter M. Holleran, Simon Jackson, Carl Grunfeld, Peter M. Elias, Kenneth R. Feingold
Publikováno v:
Journal of Lipid Research, Vol 39, Iss 2, Pp 412-422 (1998)
After permeability barrier perturbation there is an increase in the mRNA levels for key enzymes necessary for lipid synthesis in the epidermis. The mechanism(s) responsible for this regulation is unknown. Sterol regulatory element binding proteins-1a
Externí odkaz:
https://doaj.org/article/63b35a2fe85c4420bf4d2739943e9450
Autor:
Lei Zhang, Michael Ferreyros, Weiguo Feng, Melanie Hupe, Debra A Crumrine, Jiang Chen, Peter M Elias, Walter M Holleran, Lee Niswander, Daniel Hohl, Trevor Williams, Enrique C Torchia, Dennis R Roop
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0161465 (2016)
Harlequin Ichthyosis is a severe skin disease caused by mutations in the human gene encoding ABCA12. Here, we characterize a novel mutation in intron 29 of the mouse Abca12 gene that leads to the loss of a 5' splice donor site and truncation of the A
Externí odkaz:
https://doaj.org/article/53831261847f46128146a9629d899beb