Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Walter L. Eckalbar"'
Autor:
Lucile P. A. Neyton, Ravi K. Patel, Aartik Sarma, UCSF COMET Consortium, Andrew Willmore, Sidney C. Haller, Kirsten N. Kangelaris, Walter L. Eckalbar, David J. Erle, Matthew F. Krummel, Carolyn M. Hendrickson, Prescott G. Woodruff, Charles R. Langelier, Carolyn S. Calfee, Gabriela K. Fragiadakis
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Dexamethasone is the standard of care for critically ill patients with COVID-19, but the mechanisms by which it decreases mortality and its immunological effects in this setting are not understood. Here we perform bulk and single-cell RNA se
Externí odkaz:
https://doaj.org/article/a07e6d9546564fe3af6acbe7a47ce91d
Autor:
Kyung Duk Koh, Luke R. Bonser, Walter L. Eckalbar, Ofer Yizhar-Barnea, Jiangshan Shen, Xiaoning Zeng, Kirsten L. Hargett, Dingyuan I. Sun, Lorna T. Zlock, Walter E. Finkbeiner, Nadav Ahituv, David J. Erle
Publikováno v:
Cell Genomics, Vol 3, Iss 1, Pp 100229- (2023)
Summary: Epithelial responses to the cytokine interleukin-13 (IL-13) cause airway obstruction in asthma. Here we utilized multiple genomic techniques to identify IL-13-responsive regulatory elements in bronchial epithelial cells and used these data t
Externí odkaz:
https://doaj.org/article/0fea5a0b0c5749adb920911ed08a0a46
Autor:
Seoyeon Lee, Mohammad Naimul Islam, Kaveh Boostanpour, Dvir Aran, Guangchun Jin, Stephanie Christenson, Michael A. Matthay, Walter L. Eckalbar, Daryle J. DePianto, Joseph R. Arron, Liam Magee, Sunita Bhattacharya, Rei Matsumoto, Masaru Kubota, Donna L. Farber, Jahar Bhattacharya, Paul J. Wolters, Mallar Bhattacharya
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Age is associated with increasing vulnerability to both acute and chronic lung diseases. Employing genomic analysis and live lung imaging, this study reveals a profile of increased cellular senescence, telomere shortening, and fibrosis-induced impair
Externí odkaz:
https://doaj.org/article/a8e19683da4c4b2a8b772edf8db594e5
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Abstract Standard cell culture guidelines often use media supplemented with antibiotics to prevent cell contamination. However, relatively little is known about the effect of antibiotic use in cell culture on gene expression and the extent to which t
Externí odkaz:
https://doaj.org/article/26475bd8b69946bfadfaa2b8d460120a
Autor:
Jose L. Lopez, Joel L. Ramirez, Tuan Anh Phu, Phat Duong, Laura Bouchareychas, Christina R. Kuhrau, Pei-Yu Lin, Walter L. Eckalbar, Andrea J. Barczak, Joshua D. Rudolph, Lenka Maliskova, Michael S. Conte, Shant M. Vartanian, Robert L. Raffai, Adam Z. Oskowitz
Publikováno v:
PloS one, vol 18, iss 2
Objective There are currently no specific biomarkers to identify patients with abdominal aortic aneurysms (AAAs). Circulating exosomes contain microRNAs (miRNA) that are potential biomarkers for the presence of disease. This study aimed to characteri
Autor:
Betty M Booker, Tara Friedrich, Mandy K Mason, Julia E VanderMeer, Jingjing Zhao, Walter L Eckalbar, Malcolm Logan, Nicola Illing, Katherine S Pollard, Nadav Ahituv
Publikováno v:
PLoS Genetics, Vol 12, Iss 3, p e1005738 (2016)
The molecular events leading to the development of the bat wing remain largely unknown, and are thought to be caused, in part, by changes in gene expression during limb development. These expression changes could be instigated by variations in gene r
Externí odkaz:
https://doaj.org/article/0edc48829eec4fb28c1cfed01abca23f
Autor:
David J. Erle, Walter L. Eckalbar, Max A. Seibold, Celeste Eng, Jose R. Rodriguez-Santana, Scott Huntsman, Esteban G. Burchard, Marquitta J. White, Cydney Urbanek, Luke R. Bonser, Kevin L. Keys, Eunice Y. Lee, Donglei Hu, Satria Sajuthi, Angel C.Y. Mak, Hyun Min Kang, Gonçalo R. Abecasis, Michael C. Zody, Deborah A. Nickerson, Soren Germer, Deepti Jain, Elad Ziv
Publikováno v:
American journal of respiratory and critical care medicine, vol 202, iss 7
Rationale: Puerto Ricans have the highest childhood asthma prevalence in the United States (23.6%); however, the etiology is uncertain.Objectives: In this study, we sought to uncover the genetic architecture of lung function in Puerto Rican youth wit
Autor:
Izabela M. C. A. Conceição, Daniela A Pereira, Natália D. Linhares, Nadav Ahituv, Glória Regina Franco, Marcelo R. Luizon, Walter L. Eckalbar
Publikováno v:
Pharmacogenomics. 21:509-520
Aim: GDF15 levels are a biomarker for metformin use. We performed the functional annotation of noncoding genome-wide association study (GWAS) SNPs for GDF15 levels and the Genotype-Tissue Expression (GTEx)-expression quantitative trait loci (eQTLs) f
Autor:
Luke R. Bonser, Walter L. Eckalbar, Lauren Rodriguez, Jiangshan Shen, Kyung Duk Koh, Khadija Ghias, Lorna T. Zlock, Stephanie Christenson, Prescott G. Woodruff, Walter E. Finkbeiner, David J. Erle
Publikováno v:
American journal of respiratory cell and molecular biology, vol 66, iss 4
Asthma is associated with chronic changes in the airway epithelium, a key target of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Many epithelial changes, including goblet cell metaplasia, are driven by the type 2 cytokine IL-13, but
Autor:
Nadav Ahituv, Ofer Yizhar-Barnea, Walter L. Eckalbar, Xiaoning Zeng, David J. Erle, Luke R. Bonser, Kyung Duk Koh, Lorna Zlock, Walter E. Finkbeiner, Jiangshan Shen, Dingyuan I Sun
IL-13 is a central mediator of asthma1–3. Here, we used genome-wide approaches to characterize genes and regulatory elements modulated by IL-13 and other asthma-associated cytokines in airway epithelial cells and showed how they can be used for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63eae74b4e42c9f6e22045e045319583
https://doi.org/10.1101/2021.10.08.463596
https://doi.org/10.1101/2021.10.08.463596